Network Pharmacology-based Virtual Screening of Natural Products from Clerodendrum species towards the Identification of Novel Anti-cancer Therapeutics
Mol. BioSyst., 2016, Accepted Manuscript DOI: 10.1039/C6MB00807K, PaperBarbi Gogoi, Dhrubajyoti Gogoi, Yumnam Silla , Bibhuti Bhushan Kakoti, Brijmohan singh Bhau Plant derived natural products (NPs) plays a vital role in discovery of new drug molecules and these are used for development of novel therapeutic drugs for a specific disease target.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 23, 2016 Category: Molecular Biology Authors: Barbi Gogoi Source Type: research
Changes in protein expression profiles in bovine Endometrial Epithelial Cells exposed to E coli LPS challenge
Mol. BioSyst., 2016, Accepted Manuscript DOI: 10.1039/C6MB00723F, PaperCristian Piras, Yongzhi Guo, Alessio Soggiu, Metasu Chanrot, Viviana Greco, Andrea Urbani, Gilles Charpigny, Luigi Bonizzi, Paola Roncada, Patrice Humblot E coli is one of the most frequent bacteria involved in uterine diseases. Lipopolysaccharide (LPS) is a component of outer membrane of Gram-negative bacteria involved in the pathogenic processes leading... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 21, 2016 Category: Molecular Biology Authors: Cristian Piras Source Type: research
Analysis of worldwide sequence mutations in Zika virus proteins E, NS1, NS3 and NS5 from a structural point of view
Mol. BioSyst., 2017,13,122-131 DOI: 10.1039/C6MB00645K, PaperC. F. Baez, V. A. Barel, A. M. T. de Souza, C. R. Rodrigues, R. B. Varella, N. Cirauqui A structural and mutational analysis of ZIKV identifies some protein regions as potential anti-ZIKV targets. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 20, 2016 Category: Molecular Biology Authors: C. F. Baez Source Type: research
Discovery of new dual binding TNKS inhibitors of Wnt signaling inhibition by pharmacophore modeling, molecular docking and bioassay
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00712K, PaperYinglan Pu, Shuqun Zhang, Zhe Chang, Yunqin Zhang, Dong Wang, Li Zhang, Yan Li, Zhili Zuo Discovery of novel dual site TNKS inhibitors by pharmacophore modeling, molecular docking and bioassay. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 20, 2016 Category: Molecular Biology Authors: Yinglan Pu Source Type: research
Biochemical Effects of Venlafaxine on Astrocytes as Revealed by 1H NMR-Based Metabolic Profiling
Mol. BioSyst., 2016, Accepted Manuscript DOI: 10.1039/C6MB00651E, PaperLu Sun, Liang Fang, Bin Lian, Jinjun Xia, Chanjuan Zhou, Ling Wang, Qiang Mao, Xinfa Wang, Xue Gong, Zi Hong Liang, Shunjie Bai, Li Liao, Yu Wu, Peng Xie As aserotonin-norepinephrine reuptake inhibitors [SNRIs],venlafaxine is one of the most commonly prescribed clinical antidepressants, with a broad range of antidepressant effects. Accumulating evidence shows that venlafaxine may target astrocytes to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 20, 2016 Category: Molecular Biology Authors: Lu Sun Source Type: research
Ligand-responsive upregulation of 3[prime or minute] CITE-mediated translation in a wheat germ cell-free expression system
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00748A, CommunicationAtsushi Ogawa, Yuta Murashige, Junichiro Tabuchi, Taiki Omatsu We rationally designed a novel regulation-type of artificial riboswitch that upregulates the 3[prime or minute] CITE-mediated translation in response to a specific ligand without major hybridization switches in a plant expression system. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 15, 2016 Category: Molecular Biology Authors: Atsushi Ogawa Source Type: research
Integrated discovery of FOXO1-DNA stabilizers from marine natural products to restore chemosensitivity to anti-EGFR-based therapy for metastatic lung cancer
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00678G, PaperYingjia Sun, Xinghao Ai, Jingwen Hou, Xiangyun Ye, Ruijun Liu, Shengping Shen, Ziming Li, Shun Lu Small-molecule marine natural products are identified to selectively recognize and stabilize the DNA-binding conformation of FOXO1, an oncogenic transcription factor. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 15, 2016 Category: Molecular Biology Authors: Yingjia Sun Source Type: research
Metabolomics and proteomics technologies to explore herbal preparation affecting metabolic disorders using high resolution mass spectrometry
Mol. BioSyst., 2016, Accepted Manuscript DOI: 10.1039/C6MB00677A, CommunicationXijun Wang, Ai-hua Zhang, Xiaohang Zhou, Hongwei Zhao, Shiyu Zou, Chung Wah Ma, Qi Liu, Hui Sun, Liang Liu An integrative metabolomics and proteomics approaches can provide novel insights in the understanding of the biological systems. We integrated proteome and metabolome data sets for a holistic view of molecular... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 15, 2016 Category: Molecular Biology Authors: Xijun Wang Source Type: research
Control of apoptosis by SMAR1
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00525J, PaperMd. Zubbair Malik, Md. Jahoor Alam, Romana Ishrat, Subhash M. Agarwal, R. K. Brojen Singh The nuclear matrix associated proteinSMAR1 is sensitive top53 and acts as a stress inducer as well as a regulator in thep53 regulatory network. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 9, 2016 Category: Molecular Biology Authors: Md. Zubbair Malik Source Type: research
The functional consequences and prognostic value of dosage sensitivity in ovarian cancer
Mol. BioSyst., 2016, Accepted Manuscript DOI: 10.1039/C6MB00625F, PaperZichuang Yan, Yongjing Liu, Yunzhen Wei, Ning Zhao, Qiang Zhang, Cheng Wu, Zhiqiang Chang, Yan Xu Copy number alteration (CNA) represents an important class of genetic variation that may contribute to tumorigenesis, tumor growth and metastatic spread. CNA can directly affect the expressions of genes within... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 9, 2016 Category: Molecular Biology Authors: Zichuang Yan Source Type: research
miR-155 regulates high glucose-induced cardiac fibrosis via the TGF-[small beta] signaling pathway
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00649C, PaperDong Zhang, Yongchun Cui, Bin Li, Xiaokang Luo, Bo Li, Yue Tang miR-155 regulates high glucose-induced cardiac fibrosisvia the TGF-[small beta]/Smad 2 pathway. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 8, 2016 Category: Molecular Biology Authors: Dong Zhang Source Type: research
Discovery of new dual binding TNKS inhibitors of Wnt Signaling Inhibition by pharmacophore modeling, molecular docking and bioassay
Mol. BioSyst., 2016, Accepted Manuscript DOI: 10.1039/C6MB00712K, PaperYinglan Pu, Shuqun Zhang, zhe chang, Yunqin Zhang, dong wang, li zhang, Yan Li, Zhi-Li Zuo ABSTRACT: Tankyrases （TNKS）, key transmitters in the Wnt signal pathway which is very conservative in the evolution, are vital targets as they are over expressed widely in many cancers. In this... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 8, 2016 Category: Molecular Biology Authors: Yinglan Pu Source Type: research
Ligand-responsive upregulation of 3' CITE-mediated translation in a wheat germ cell-free expression system
Mol. BioSyst., 2016, Accepted Manuscript DOI: 10.1039/C6MB00748A, CommunicationAtsushi Ogawa, Yuta Murashige, Junichiro Tabuchi, Taiki Omatsu We have rationally constructed a novel regulation-type of artificial riboswitch that ligand-dose dependently upregulates translation initiation mediated by a 3' cap-independent translation element (3' CITE) with no major hybridization switches... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 8, 2016 Category: Molecular Biology Authors: Atsushi Ogawa Source Type: research
Effect of small molecules on cell reprogramming
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00595K, Review ArticleM. Baranek, A. Belter, M. Z. Naskret-Barciszewska, M. Stobiecki, W. T. Markiewicz, J. Barciszewski Small molecules cause pluripotency induction through epigenetic changes such as DNA methylation, histone modifications, RNA noncoding and chromatin remodeling. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 5, 2016 Category: Molecular Biology Authors: M. Baranek Source Type: research
Modeling ion permeation through a bacterial voltage-gated calcium channel CaVAb using molecular dynamics simulations
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00690F, PaperJamal Adiban, Yousef Jamali, Hashem Rafii-Tabar Ca2+ ion binds tightly to the center of the selectivity filter of voltage-gated calcium channels. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 5, 2016 Category: Molecular Biology Authors: Jamal Adiban Source Type: research
