Discovery of new dual binding TNKS inhibitors of Wnt Signaling Inhibition by pharmacophore modeling, molecular docking and bioassay

Mol. BioSyst., 2016, Accepted Manuscript DOI: 10.1039/C6MB00712K, PaperYinglan Pu, Shuqun Zhang, zhe chang, Yunqin Zhang, dong wang, li zhang, Yan Li, Zhi-Li Zuo ABSTRACT: Tankyrases （TNKS）, key transmitters in the Wnt signal pathway which is very conservative in the evolution, are vital targets as they are over expressed widely in many cancers. In this... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Molecular Biosystems - Category: Molecular Biology Authors: Source Type: research