Molecular Dynamics Simulations Elucidate Conformational Selection and Induced Fit Mechanisms in the Binding of PD-1 and PD-L1

Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00036G, PaperWenping Liu, Bing Huang, Yashu Kuang, Guangjian Liu Blockage of the interactions between immunologic checkpoint protein PD-1 and its ligand PD-L1 showed efficacy for cancer treatment. X-ray structures have captured static conformational snapshots of PD-1 and revealed that... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Molecular Biosystems - Category: Molecular Biology Authors: Source Type: research