Multidisciplinary treatment of total placenta previa in a blood-refusal parturient for a religious reason.
Background: Because patients who are Jehovah ’s Witnesses refuse consent to blood transfusion and blood products, a multidisciplinary treatment for total placenta previa cases is needed. Here we report a successful treatment in a woman with total placenta previa using a closed-circuit acute normovolemic hemodilution (ANH), a closed-circuit i ntraoperative blood salvage (IBS), and biological products. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Sayaka Tachi Source Type: research
Impaired autophagy and transthyretin protein aggregation in early onset preeclampsia
Purpose: Transthyretin (TTR), a transporter of thyroxine and retinol, is aggregated in human placentas, and the aggregated TTR induces preeclampsia-like features in the humanized mouse model (Am J Paho, 2013). We also have reported that impairment of autophagy contributed to protein aggregation in preeclamptic placentas. The purpose of this study is to clarify the correlation between TTR aggregation and autophagy, which maintains homeostasis. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Akitoshi Nakashima Source Type: research
Placental-specific microRNAs were transferred into decidual natural killer cells in the first trimester of pregnancy
In this study, we investigated whether placenta-specific miRNAs are transferred into decidual NK (dNK) cells in the first trimester of pregnancy. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Manabu Ogoyama, Akihide Ohkuchi, Tomoko Shima, Shigeru Saito, Toshihiro Takizawa Source Type: research
A pregnant woman with familial steatcystoma multiplex and postpartum hemorrhage
Case: A 40-year old woman, 0 gravida, 0 para, had Monochorionic diamnionic twin after assisted reproductive technology. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Rie Oyama Source Type: research
Measurement of PlGF, sFlt-1, sFlt-1/PlGF ratio, and sEndoglin at the 2nd trimester is useful for predicting pregnant women with fetal growth restriction (FGR) who will subsequently develop preeclampsia (PE) or not
Objectives: It is reported that FGR and PEare associated with abnormal profiles of angiogenic markers in maternal circulation. Mothers with FGR fetuses are at increased risks for developing PE. The aim of our study is to determine whether maternal serum levels of angiogenic factors can predict mothers diagnosed with FGR will subsequently develop PE or not. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Sakiko Nanjo Source Type: research
Accumulation of prostaglandin E2 in amniotic fluid and expression of PGE synthases and transporters during human labor
Metabolites of arachidonic acid (AA), especially prostaglandin E2 (PGE2), are known to induce uterine contractions and labor. PGE2 production from AA is catalyzed by cyclooxygenases (COX)-1, COX-2, and PGE synthases (cytosolic PGE synthase (cPGES) and microsomal PGES (mPGES)-1 and mPGES-2). PGE2 is transported to the extracellular space by transporters such as SLCO2A1 (solute carrier organic anion transporter family member 2A1), and exerts its effects by binding to the target receptor(s). However, the detailed mechanism of PGE2 production and transportation during human labor is largely unknown. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Nanase Takahashi Source Type: research
Functional difference between decidual dendritic cells in late preterm birth with and without acute chorioamnionitis
Objective: Acute chorioamnionitis (aCAM) is the principal antecedent of preterm birth, which is the most common obstetric complication in humans. However, the etiology of preterm birth without aCAM remains unknown. Indeed, the incidence of histologic aCAM in late preterm birth is lower than that in moderately and extremely preterm births. In addition, recent research suggests that late preterm birth could be implicated with an increased incidence of neonatal complications, such as mental retardation, respiratory distress, and cerebral palsy in childhood. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Yasuyuki Negishi Source Type: research
The differencial diagnosis of multivesicular placental disorders with fetus; partial hydatidiform mole, complete hydatidiform mole coexistent with a fetus and placental mesenchymal dysplasia.
Objectives: Because of differential prognosis, placental mesenchymal dysplasia(PMD) needs to be distinguished from other multivesicular placental disorders with fetus; partial hydatidiform mole(PHM) with a fetus and complete hydatidiform mole coexistent with a fetus(CHMCF). The aim of this study is to describe these ultrasonographic features. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Akiko Omoto Source Type: research
The viability of pregnancy in women over the age of 43
Introduction: A few weeks ago a 43 year old woman came to see me and said she wanted another baby. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Masayoshi Arizawa Source Type: research
3D imaging of full-term human placental villi by serial block face-scanning electron microscopy
Objective: he surface of the chorionic villi consists of two layers: the outermost syncytiotrophoblast (STB) layer and the inner cytotrophoblast (CTB) layer; the two layers serve as essential structures in placental function. However, the gestation-dependent structural changes of the layers still remained unclear. We investigated the ultrastructure of terminal villi by an advanced three-dimensional (3D) imaging technique, i.e., serial block-face scanning electron microscopy (SBF-SEM). (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Haruhiko Shimada, Yuuki Yamaguchi, Takami Takizawa, Hironori Takahashi, Akihid Ohkuchi, Toshiyuki Takeshita, Shigeki Matsubara, Toshihiro Takizawa Source Type: research
A comprehensive expression analysis of placental transcripts in primary trophoblast cells during in vitro syncytialization
Objective: Spontaneous cell-cell fusion is relatively rare in normal human tissues but is central to the formation of the placental syncytiotrophoblast layer, across which all gas and nutrient transfer occurs at the maternal-fetal interface. Although several fusion-associated molecules, including some derived from human endogenous retroviruses (HERVs) have been implicated in placental syncytialization, our understanding of the process remains imcomplete and additional key molecules and regulatory processes are certainly involved. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Sugimoto Jun Source Type: research
Effects of Chronic abruption-oligohydramnios sequence (CAOS) on baby
Object: To learn more about respiratory complications in babies whose mothers suffered chronic abruption-oligohydramnios sequence (CAOS). (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Masayoshi Arizawa Source Type: research
Towards a definition of placentomegaly
Object: There is no textbook definition of placentomegaly. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Masayoshi Arizawa Source Type: research
Retrospective analysis of the association of opaque fetal membrane with chorioamnionitis and early neonatal complications: Importance of gross examination of the placenta
Objective: Placental pathological examination is expected as witness for pathogenesis of perinatal abnormality. Opaque fetal membrane is known as one of the abnormal findings of the placenta which indicates chorioamnionitis (CAM). However, the sensitivity, specificity, and clinical efficiency have not been established. The aim of the present study is to retrospectively evaluate the association of the opaque fetal membrane with incidence of CAM and early neonatal complications. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Yoshimasa Horikoshi Source Type: research
Two cases of chronic abruption with fetal growth restriction and a decrease in amniotic fluid
Introduction: Chronic abruption (CA) is a slowly progressive disease characterized by the presence of abruption and/or hematoma on the edge of the placenta, and vaginal bleeding persisting 7 days or longer. On the other hand, it is known that chronic abruption-oligohydramnions sequence (CAOS) may cause neonatal chronic lung disease (CLD). Here we report 2 cases of CA with fetal growth restriction (FGR) and a decrease in amniotic fluid (AF) following subchorionic hemorrhage (SCH), which had adverse outcomes in their neonates. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Akiko Uchida Source Type: research
