Classics revisited: Miguel Fern ández on germ layer inversion and specific polyembryony in armadillos
Miguel Fern ández was an Argentinian zoologist who published the first account of obligate polyembryony in armadillos. His contribution is here discussed in relation to his contemporaries, Newman and Patterson, and more recent work. (Source: Placenta)
Source: Placenta - November 15, 2017 Category: Reproduction Medicine Authors: A.M. Carter Source Type: research
Birth weight to placenta weight ratio and its relationship to ultrasonic measurements, maternal and neonatal morbidity: A prospective cohort study of nulliparous women
Birth weight to placenta weight (BWPW)-ratio is an indicator of the ability of the placenta to maintain adequate nutrient supply to the fetus. We sought to investigate the relationship between BWPW-ratio with fetal growth, utero-placental Doppler and neonatal and maternal morbidity. (Source: Placenta)
Source: Placenta - November 15, 2017 Category: Reproduction Medicine Authors: N. Salavati, S.J. Gordijn, U. Sovio, R. Zill-E-Huma, A. Gebril, D.S. Charnock-Jones, S.A. Scherjon, G.C.S. Smith Source Type: research
Human predecidual stromal cells have distinctive characteristics of pericytes: Cell contractility, chemotactic activity, and expression of pericyte markers and angiogenic factors
Human decidual stromal cells (DSCs) play a key role in maternal –fetal interactions. Precursors of DSCs (preDSCs) localize around vessels in both the endometrium and decidua. Previous studies suggested a relationship between preDSCs and pericytes because these cells share a perivascular location, alpha smooth muscle actin (α-SM actin) expression and the abili ty to contract under the effects of cytokines. (Source: Placenta)
Source: Placenta - November 15, 2017 Category: Reproduction Medicine Authors: Raquel Mu ñoz-Fernández, Claudia de la Mata, Alejandro Prados, Ana Perea, María José Ruiz-Magaña, Tatiana Llorca, Pablo Fernández-Rubio, Osmany Blanco, Ana C. Abadía-Molina, Enrique G. Olivares Source Type: research
Dysregulated placental microRNAs in early and late onset Preeclampsia
To determine the miRNA expression profile in placentas complicated by Preeclampsia (PE) and compare it to uncomplicated pregnancies. (Source: Placenta)
Source: Placenta - November 14, 2017 Category: Reproduction Medicine Authors: Alexandra Lykoudi, Aggeliki Kolialexi, George I. Lambrou, Maria Braoudaki, Charalampos Siristatidis, George Konstantinos Papaioanou, Maria Tzetis, Ariadni Mavrou, Nikolas Papantoniou Source Type: research
Is there a role for exosomes in foetoplacental endothelial dysfunction in gestational diabetes mellitus?
Gestational diabetes mellitus (GDM) is a disease of pregnancy associated with endothelial dysfunction in the foetoplacental vasculature. Foetoplacental endothelial dysfunction is characterized by changes in the l-arginine –adenosine signalling pathway and inflammation. The mechanisms involved in these alterations are suggested to be hyperglycaemia, hyperinsulinemia, and oxidative stress. These conditions increase the release of exosomes, nanovesicles that are generated from diverse cell types, including endothelial cells. (Source: Placenta)
Source: Placenta - November 14, 2017 Category: Reproduction Medicine Authors: Tamara S áez, Paul de Vos, Luis Sobrevia, Marijke M. Faas Source Type: research
Maternal high estradiol exposure alters CDKN1C and IGF2 expression in human placenta
The increased maternal estradiol (E2) concentrations induced by assisted reproductive technology (ART) result in lower birth weight of offspring, which is associated with increased risk of adult diseases. However, the exact mechanism remains unknown. The present study investigated the effect of high E2 exposure on the expression of imprinted genes CDKN1C and IGF2 in human placentas and the DNA methylation status of their differential methylation regions (DMRs). (Source: Placenta)
Source: Placenta - November 14, 2017 Category: Reproduction Medicine Authors: Xi-Jing Chen, Feng Chen, Ping-Ping Lv, Dan Zhang, Guo-Lian Ding, Xiao-Ling Hu, Chun Feng, Jian-Zhong Sheng, He-Feng Huang Source Type: research
Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling
Cultured primary human trophoblasts (PHT), derived from term placentas, are relatively resistant to infection by diverse viruses. The resistance can be conferred to non-trophoblastic cells by pre-exposing them to medium that was conditioned by PHT cells. This antiviral effect is mediated, at least in part, by microRNAs (miRNA) expressed from the chromosome 19 microRNA cluster (C19MC). Recently we showed that PHT cells and cells pre-exposed to PHT medium are also resistant to infection by Zika virus (ZIKV), an effect mediated by the constitutive release of the type III interferons (IFN) IFN lambda-1 and IFN lambda-2 in trop...
Source: Placenta - November 10, 2017 Category: Reproduction Medicine Authors: Avraham Bayer, Nicholas J. Lennemann, Yingshi Ouyang, Elena Sadovsky, Megan A. Sheridan, R. Michael Roberts, Carolyn B. Coyne, Yoel Sadovsky Source Type: research
Changes in maternal placental growth factor levels during term labour
Placental growth factor (PlGF) has important angiogenic function that is critical to placental development. Lower levels of PlGF are associated with fetal growth restriction, pre-eclampsia and intrapartum fetal compromise. The aim of this study was to investigate the effect of labour on maternal PlGF levels. (Source: Placenta)
Source: Placenta - November 8, 2017 Category: Reproduction Medicine Authors: Liam Dunn, Christopher Flatley, Sailesh Kumar Source Type: research
Placental baseline conditions modulate the hyperoxic BOLD-MRI response
Human pregnancies complicated by placental dysfunction may be characterized by a high hyperoxic Blood oxygen level-dependent (BOLD) MRI response. The pathophysiology behind this phenomenon remains to be established. The aim of this study was to evaluate whether it is associated with altered placental baseline conditions, including a lower oxygenation and altered tissue morphology, as estimated by the placental transverse relaxation time (T2*). (Source: Placenta)
Source: Placenta - November 7, 2017 Category: Reproduction Medicine Authors: Marianne Sinding, David A. Peters, Sofie S. Poulsen, Jens B. Fr økjær, Ole B. Christiansen, Astrid Petersen, Niels Uldbjerg, Anne Sørensen Source Type: research
Proteomics and bioinformatics analysis of altered protein expression in the placental villous tissue from early recurrent miscarriage patients
Recurrent miscarriage (RM) affects 5% of women, it has an adverse emotional impact on women. Because of the complexities of early development, the mechanism of recurrent miscarriage is still unclear. We hypothesized that abnormal placenta leads to early recurrent miscarriage (ERM). The aim of this study was to identify ERM associated factors in human placenta villous tissue using proteomics. Investigation of these differences in protein expression in parallel profiling is essential to understand the comprehensive pathophysiological mechanism underlying recurrent miscarriage (RM). (Source: Placenta)
Source: Placenta - November 4, 2017 Category: Reproduction Medicine Authors: Hai-Tao Pan, Hai-Gang Ding, Min Fang, Bin Yu, Yi Cheng, Ya-Jing Tan, Qi-Qin Fu, Bo Lu, Hong-Guang Cai, Xin Jin, Xian-Qing Xia, Tao Zhang Source Type: research
Resveratrol mitigates trophoblast and endothelial dysfunction partly via activation of nuclear factor erythroid 2-related factor-2
The objective of this study was to assess whether resveratrol could reduce placental oxidative stress and production of anti-angiogenic factors in vitro and/or improve in vitro markers of endothelial dysfunction via Nrf2 activation. (Source: Placenta)
Source: Placenta - November 3, 2017 Category: Reproduction Medicine Authors: Seshini Gurusinghe, Annie G. Cox, Rahana Rahman, Siow T. Chan, Ruth Muljadi, Harmeet Singh, Bryan Leaw, Joanne C. Mockler, Padma Murthi, Rebecca Lim, Euan M. Wallace Source Type: research
Title Page/Editorial Board
(Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Source Type: research
IFPA Pages
(Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Source Type: research
Epithelial-Mesenchymal Transition (EMT) Stimulates the healing of ruptured amnion in mouse pPROM Model
In this study, we investigated mechanisms of healing of pPROM in relation to innate immunity. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Haruta Mogami Source Type: research
Progesterone suppresses the enhancement of inflammatory cytokines on fetal membrane in preterm birth mouse model with chronic dental infection
Objective: Progesterone plays an essential role to maintaine pregnancy by anti-inflammatory effect in the myometrium, however, this effect has not been less understood in the fetal membrane. We previously reported that mice with dental Porphyromonas gingivalis (P.g) infection (P.g mice) could be useful as a model of preterm birth. In this model, inflammation on the fetal membrane is thought to be the main cause leading to preterm birth as levels of cyclooxygenase 2 (COX-2) and interleukin (IL)-1 β are highly up-regulated. (Source: Placenta)
Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Yuko Teraoka Source Type: research
