Trinucleate uterine epithelial cells as evidence for White-tail Deer trophoblast binucleate cell migration and as markers of placental binucleate cell dynamics in a variety of wild ruminants
The unicellular trophoblast epithelium of all ruminants so far investigated contains 15 –20% binucleate cells with numerous secretory granules. Electron microscope (EM) studies of the domesticated cow, ewe, goat and deer species have established that these BNC migrate out of the trophoblast epithelium to fuse with the apposed maternal uterine epithelial cells or derivative to form fe tomaternal tissue throughout pregnancy. However there is one careful EM study of the trophoblast of a wild ruminant, the White-tail deer, which found the usual number of BNC but no evidence of any migration or fusion. (Source: Placenta)
Source: Placenta - December 15, 2017 Category: Reproduction Medicine Authors: F.B. Peter Wooding, David Osborn, Gary J. Killian Source Type: research
IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction
Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2017 there were four themed workshops, all of which are summarized in this report. These workshops discussed new knowledge and technological innovations in the following areas of research: 1) placental bed; 2) 3D structural modeling; 3) clinical placentology; 4) treatment of placental dysfunction. (Source: Placenta)
Source: Placenta - December 15, 2017 Category: Reproduction Medicine Authors: Ganesh Acharya, John Aplin, Paul Brownbill, Judith Bulmer, Graham Burton, Larry Chamley, Igor Chernyavsky, Alys Clark, Sally Collins, Elizabeth Cottrell, Mark Dilworth, David Elad, Marcel Filoche, Natalie Hannan, Alexander E.P. Heazell, Oliver Jensen, Edw Source Type: research
Combination of first trimester serum afamin levels and three-dimensional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in low-risk pregnancies
Aim of the study was to assess the correlation of first trimester serum afamin levels with three-dimensional placental bed vascularization in pregnant women and its prognostic value for predicting pre-eclampsia and future fetal and maternal complications during pregnancy. (Source: Placenta)
Source: Placenta - December 15, 2017 Category: Reproduction Medicine Authors: Allessandra Tramontana, Eleonore Pablik, Gerhard Stangl, Beda Hartmann, Hans Dieplinger, Erich Hafner Source Type: research
Utility of DNA methylation to assess placental health
DNA methylation (DNAm), a mitotically stable epigenetic mark, can influence as well as reflect gene expression. DNAm has been gaining interest for use as a biomarker for many conditions including placental insufficiency, specifically preeclampsia (PE) and intrauterine growth restriction (IUGR). Additionally, DNAm may retain a “memory” of earlier in utero exposures and hence provide insight into pathogeneses occurring earlier in gestation. This review will discuss the placental DNA methylome, the uses of DNAm to assess placental health, and considerations and limitations to understand in epigenome-wide association stu d...
Source: Placenta - December 14, 2017 Category: Reproduction Medicine Authors: Samantha L. Wilson, Wendy P. Robinson Source Type: research
Sirtuin1 is required for proper trophoblast differentiation and placental development in mice
Placental insufficiency, arising from abnormal trophoblast differentiation and function, is a major cause of fetal growth restriction. Sirtuin-1 (Sirt1) is a ubiquitously-expressed NAD-dependent protein deacetylase which plays a key role in numerous cellular processes, including cellular differentiation and metabolism. Though Sirt1 has been widely studied, its role in placentation and trophoblast differentiation is unclear. (Source: Placenta)
Source: Placenta - December 7, 2017 Category: Reproduction Medicine Authors: Kanaga Arul Nambi Rajan, Marwa Khater, Francesca Soncin, Donald Pizzo, Matteo Moretto-Zita, Jonathan Pham, Orysya Stus, Pooja Iyer, Veronique Tache, Louise C. Laurent, Mana M. Parast Source Type: research
Ultrasound screening of umbilical cord abnormalities and delivery management
With the improvement of prenatal diagnoses of foetuses, the prevalence of stillbirth due to foetal anomaly after mid-gestation decreased, whereas that of stillbirth associated with umbilical cord factors tended to increase. Prenatal detection of umbilical cord abnormalities and appropriate management during the antenatal period and delivery based on the ultrasound diagnosis will improve the perinatal morbidity and mortality rates. In the present review, the strategy to reduce the incidence of foetal compromise due to umbilical cord problems is discussed considering the current knowledge regarding the physiological and path...
Source: Placenta - December 7, 2017 Category: Reproduction Medicine Authors: Junichi Hasegawa Source Type: research
Progesterone attenuates hypertension and autoantibody levels to the angiotensin II type 1 receptor in response to elevated cadmium during pregnancy
Preeclampsia is associated with the presence of pathogenic angiotensin-receptor-activating autoantibodies. Cadmium is an increasingly prevalent environmental pollutant that can mimic oestrogens, which may enhance immunoglobulin production. Progesterone exerts opposite effects to oestrogen. (Source: Placenta)
Source: Placenta - December 7, 2017 Category: Reproduction Medicine Authors: Qiong Zhang, Yinping Huang, Keke Zhang, Yan Yan, Jie Wu, Fan Wang, Yuan Zhao, Huifang Xu, Wei Jiang, Danyang Yu, Yongtao Chen, Duyun Ye Source Type: research
Fetal-sex determination of human placental tissues
It is now demonstrated that the sex-specific maternal-placental-fetal interaction plays an important role in placental functions and pathologies. Determination of fetal-sex may therefore be an important consideration in studies using placenta samples. In this present study, we describe a simple, fast, and cheap protocol, which allows the fetal-sex determination of placental tissues from various starting materials (villi or formalin-fixed, paraffin-embedded (FFPE) tissues, isolated cytotrophoblasts or cellular debris from whole cell lysates, and cDNA) by a single duplex PCR reaction followed by agarose gel electrophoresis. (Source: Placenta)
Source: Placenta - December 2, 2017 Category: Reproduction Medicine Authors: S éverine A. Degrelle, Thierry Fournier Tags: Technical note Source Type: research
Title Page/Editorial Board
(Source: Placenta)
Source: Placenta - December 1, 2017 Category: Reproduction Medicine Source Type: research
IFPA Pages
(Source: Placenta)
Source: Placenta - December 1, 2017 Category: Reproduction Medicine Source Type: research
Preliminary metabolomics analysis of placenta in maternal obesity
Metabolomics identifies phenotypical groups with specific metabolic profiles, being increasingly applied to several pregnancy conditions. This is the first preliminary study analyzing placental metabolomics in normal weight (NW) and obese (OB) pregnancies. (Source: Placenta)
Source: Placenta - November 29, 2017 Category: Reproduction Medicine Authors: Claudia Fattuoni, Chiara Mand ò, Francesco Palmas, Gaia Maria Anelli, Chiara Novielli, Estefanìa Parejo Laudicina, Valeria Maria Savasi, Luigi Barberini, Angelica Dessì, Roberta Pintus, Vassilios Fanos, Antonio Noto, Irene Cetin Source Type: research
New imaging markers for preconceptional and first-trimester utero-placental vascularization
This study aims to develop a feasible and reliable method to assess preconceptional and early first-trimester utero-placental vascular volumes using three-dimensional power Doppler (3D PD) ultrasound on two different Virtual Reality (VR) systems. (Source: Placenta)
Source: Placenta - November 27, 2017 Category: Reproduction Medicine Authors: I.F. Reijnders, A.G.M.G.J. Mulders, M.P.H. Koster, A.H.J. Koning, A. Frudiger, S.P. Willemsen, E. Jauniaux, G.J. Burton, R.P.M. Steegers-Theunissen, E.A.P. Steegers Source Type: research
Towards standardized criteria for diagnosing chronic intervillositis of unknown etiology: A systematic review
Chronic intervillositis of unknown etiology (CIUE) is a poorly understood, relatively rare condition characterized histologically by the intervillous infiltration of mononuclear cells in the placenta. Clinically, CIUE is associated with poor pregnancy outcome (e.g., impaired fetal growth, preterm birth, fetal death) and high risk of recurrence in subsequent pregnancies. Because CIUE is not defined consistently, it is essential to clearly define this condition. We therefore review the published definitions of CIUE. (Source: Placenta)
Source: Placenta - November 23, 2017 Category: Reproduction Medicine Authors: M. Bos, P.G.J. Nikkels, D. Cohen, J.W. Schoones, K.W.M. Bloemenkamp, J.A. Bruijn, H.J. Baelde, M.L.P. van der Hoorn, R.J. Turner Source Type: research
Identification of potential early biomarkers of preeclampsia
It is thought that poor placental perfusion caused by inadequate remodelling of the maternal spiral arteries leads to preeclampsia (PE). To identify novel signalling pathways that contribute to PE pathogenesis and to create prerequisites for the non-invasive diagnosis of PE before clinical manifestations of the disease, this study aimed to evaluate miRNA expression levels in the placenta and blood plasma of pregnant women. (Source: Placenta)
Source: Placenta - November 20, 2017 Category: Reproduction Medicine Authors: Angelika V. Timofeeva, Vladyslava A. Gusar, Nataliya E. Kan, Kseniya N. Prozorovskaya, Anna O. Karapetyan, Oleg R. Bayev, Vitaliy V. Chagovets, Sergei F. Kliver, Daria Yu. Iakovishina, Vladimir E. Frankevich, Gennadiy T. Sukhikh Source Type: research
