Sirtuin1 is required for proper trophoblast differentiation and placental development in mice
Placental insufficiency, arising from abnormal trophoblast differentiation and function, is a major cause of fetal growth restriction. Sirtuin-1 (Sirt1) is a ubiquitously-expressed NAD-dependent protein deacetylase which plays a key role in numerous cellular processes, including cellular differentiation and metabolism. Though Sirt1 has been widely studied, its role in placentation and trophoblast differentiation is unclear.
Source: Placenta - Category: Reproduction Medicine Authors: Kanaga Arul Nambi Rajan, Marwa Khater, Francesca Soncin, Donald Pizzo, Matteo Moretto-Zita, Jonathan Pham, Orysya Stus, Pooja Iyer, Veronique Tache, Louise C. Laurent, Mana M. Parast Source Type: research
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