Virtual reality imaging techniques in the study of embryonic and early placental health
Embryonic and placental growth and development in the first trimester of pregnancy have impact on the health of the fetus, newborn, child and even the adult. This emphasizes the importance of this often neglected period in life. The development of three-dimensional transvaginal ultrasonography in combination with virtual reality (VR) opens the possibility of accurate and reliable visualization of embryonic and placental structures with real depth perception. These techniques enable new biometry and volumetry measurements that contribute to the knowledge of the (patho)physiology of embryonic and early placental health. (Source: Placenta)
Source: Placenta - January 5, 2018 Category: Reproduction Medicine Authors: Melek Rousian, Maria P.H. Koster, Annemarie G.M.G.J. Mulders, Anton H.J. Koning, R égine P.M. Steegers-Theunissen, Eric A.P. Steegers Source Type: research
Remodeling of the cardiovascular circulation in fetuses of mothers with diabetes: A fetal computational model analysis
Myocardial structural and functional abnormalities are known to occur in fetuses of mothers with diabetes mellitus (FMDM) and in their offspring. The main aim of this investigation was to explore the cardiovascular circulatory patterns in FMDM using a validated lumped computational model of the cardiovascular system. (Source: Placenta)
Source: Placenta - January 4, 2018 Category: Reproduction Medicine Authors: Aparna Kulkarni, Patricia Garcia – Cañadilla, Abdullah Khan, Jose Miguel Lorenzo, Karen Beckerman, Brenda Valenzuela-Alcaraz, Monica Cruz-Lemini, Olga Gomez, Eduard Gratacos, Fatima Crispi, Bart Bijnens Source Type: research
Detyrosinated tubulin is decreased in fetal vessels of preeclampsia placentas
Preeclampsia is a hypertensive, gestational disease, which is still the leading cause of pregnancy related morbidity and mortality. The impairment of placental angiogenesis and vascularization is discussed to be of etiopathologic relevance. Deytrosination and tyrosination of α-tubulin is important for the stability and dynamics of microtubules. An increase of α-tubulin detyrosination leads to microtubule stabilization, which is an essential prerequisite for physiologic vascular tube morphogenesis during angiogenesis. (Source: Placenta)
Source: Placenta - December 30, 2017 Category: Reproduction Medicine Authors: H. Huebner, B. Knoerr, A. Betzler, A. Hartner, S. Kehl, F. Baier, D.L. Wachter, R. Strick, M.W. Beckmann, F.B. Fahlbusch, M. Ruebner Source Type: research
Editorial
Trophoblast Research is a record of the annual meetings of the International Federation of Placenta Associations (IFPA). The present volume, “Placenta: The frontier between mother and fetus” reports on the IFPA Meeting 2017 in Manchester, UK. It comprises four review articles based on plenary presentations and one workshop report. The meeting was hosted by the European Placental Group (EPG), under the excellent leadership of Melissa Westwood and her team. The high quality of the presentations will be apparent from the papers published in this volume. (Source: Placenta)
Source: Placenta - December 27, 2017 Category: Reproduction Medicine Authors: Gendie E. Lash Source Type: research
Editorial
Trophoblast Research is a record of the annual meetings of the International Federation of Placenta Associations (IFPA). The present volume, “Placenta: The frontier between mother and fetus” reports on IFPA Meeting 2017 in Manchester, UK. It comprises four review articles based on plenary presentations and one workshop report. The meeting was hosted by the European Placental Group (EPG), under the excellent leadership of Melissa West wood and her team. The high quality of the presentations will be apparent from the papers published in this volume. (Source: Placenta)
Source: Placenta - December 27, 2017 Category: Reproduction Medicine Authors: Gendie E. Lash Source Type: research
Title Page/Editorial Board
(Source: Placenta)
Source: Placenta - December 23, 2017 Category: Reproduction Medicine Source Type: research
IFPA Pages
(Source: Placenta)
Source: Placenta - December 23, 2017 Category: Reproduction Medicine Source Type: research
Identification of haptoglobin switch-on status in archived placental specimens indicates antenatal exposure to inflammation and potential participation of the fetus in triggering preterm birth
Haptoglobin (Hp) has key immunoregulatory roles that vary with phenotype (Hp1-1, Hp2-1, Hp2-2). Cord blood Hp expression is switched-off in the normal fetus. We hypothesized that in the setting of fetal inflammation placenta becomes inundated with Hp of fetal origin that in turn modulates the output of PGE2 and MMP-9 in a phenotype dependent manner. (Source: Placenta)
Source: Placenta - December 23, 2017 Category: Reproduction Medicine Authors: Megan E. McCarthy, Catalin S. Buhimschi, John T. Hardy, Antonette T. Dulay, Christine A. Laky, Mert-Ozan Bahtyiar, Ramesh Papanna, Guomao Zhao, Irina A. Buhimschi Source Type: research
ARHGEF11 affecting the placental insulin signaling pathway in fetal macrosomia of normal glucose tolerance pregnant women
This study aimed to investigate the mechanism of Rho guanine nucleotide exchange factor 11 (ARHGEF11) and the insulin signaling pathway in placenta affecting fetal overgrowth in NGT and GDM pregnant women. (Source: Placenta)
Source: Placenta - December 20, 2017 Category: Reproduction Medicine Authors: Wanyi Zhang, Rina Su, Li Lin, Huixia Yang Source Type: research
Placental pathologic changes and perinatal outcomes in placenta previa
Placenta previa is a condition in which the placenta implants in the poorly vascularized lower uterine segment, which may result in inadequate uteroplacental perfusion, in turn, adversely affect the neonatal outcome. Abnormal placentation may also lead to severe postpartum hemorrhage as placenta separation proceeds. We aimed to evaluate the differences in placental histopathology and perinatal outcomes in pregnancies complicated with placenta previa and controls. (Source: Placenta)
Source: Placenta - December 20, 2017 Category: Reproduction Medicine Authors: Eun Jung Jung, Hwa Jin Cho, Jung Mi Byun, Dae Hoon Jeong, Kyung Bok Lee, Moon Su Sung, Ki Tae Kim, Young Nam Kim Source Type: research
Relationship between second-trimester amniotic fluid levels of Prokineticin-1 and Matrix Metalloproteinase-2 with adverse pregnancy outcome
To investigate the levels of Prokineticin-1 (PROK1) and matrix metalloproteinase-2 (MMP-2) in second-trimester amniotic fluid (AF). AF samples were investigated in 81 patients. AF-PROK1 and AF-MMP-2 were not significantly associated with adverse pregnancy outcomes (preeclampsia, intrauterine growth retardation, spontaneous preterm birth, gestational diabetes, gestational hypertension). AF-PROK1 levels in patients with abnormal first-trimester screening were significantly higher than those who underwent amniocentesis due to abnormal second-trimester screening tests (p = .04). (Source: Placenta)
Source: Placenta - December 18, 2017 Category: Reproduction Medicine Authors: Selen G. Erzincan, Fusun G. Varol, Cihan Inan, N. Cenk Sayin Tags: Technical note Source Type: research
New insights in the pathophysiology of complete hydatidiform mole
The majority of complete hydatidiform moles (CHM) are detected on ultrasound examination by the end of the first trimester when they present as multiple sonolucent cysts. To better understand the pathophysiology of this unique placental pathology and improve its prenatal diagnosis and management we have reviewed the ultrasound features of CHM before the appearance of cystic changes. (Source: Placenta)
Source: Placenta - December 16, 2017 Category: Reproduction Medicine Authors: Eric Jauniaux, Maria Memtsa, Jemma Johns, Jackie A. Ross, Davor Jurkovic Source Type: research
IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction
Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2017 there were four themed workshops, all of which are summarized in this report. These workshops discussed new knowledge and technological innovations in the following areas of research: 1) placental bed; 2) 3D structural modeling; 3) clinical placentology; 4) treatment of placental dysfunction. (Source: Placenta)
Source: Placenta - December 15, 2017 Category: Reproduction Medicine Authors: Ganesh Acharya, John Aplin, Paul Brownbill, Judith Bulmer, Graham Burton, Larry Chamley, Igor Chernyavsky, Alys Clark, Sally Collins, Elizabeth Cottrell, Mark Dilworth, David Elad, Marcel Filoche, Natalie Hannan, Alexander E.P. Heazell, Oliver Jensen, Edw Source Type: research
Decreased expression of fibroblast growth factor 13 in early-onset preeclampsia is associated with the increased trophoblast permeability
Intracellular protein fibroblast growth factor 13 (FGF13) is highly expressed in human placenta, although its biological function remains unexplored. The aims of this study were to investigate the expression of FGF13 in placentae with early-onset preeclampsia (PE) and the associated mechanisms in the pathophysiology of PE. (Source: Placenta)
Source: Placenta - December 15, 2017 Category: Reproduction Medicine Authors: Xiaojing Yue, Ying Sun, Mei Zhong, Yanlin Ma, Yanxing Wei, Fei Sun, Lu Xiao, Mian Liu, Jianing Chen, Yingjun Lai, Chuming Yan, Liping Huang, Yanhong Yu Source Type: research
