Detyrosinated tubulin is decreased in fetal vessels of preeclampsia placentas

Preeclampsia is a hypertensive, gestational disease, which is still the leading cause of pregnancy related morbidity and mortality. The impairment of placental angiogenesis and vascularization is discussed to be of etiopathologic relevance. Deytrosination and tyrosination of α-tubulin is important for the stability and dynamics of microtubules. An increase of α-tubulin detyrosination leads to microtubule stabilization, which is an essential prerequisite for physiologic vascular tube morphogenesis during angiogenesis.

Source: Placenta - December 30, 2017 Category: Reproduction Medicine Authors: H. Huebner, B. Knoerr, A. Betzler, A. Hartner, S. Kehl, F. Baier, D.L. Wachter, R. Strick, M.W. Beckmann, F.B. Fahlbusch, M. Ruebner Source Type: research