Serum podocalyxin for early detection of preeclampsia at 11 –13 weeks of gestation
In this study we investigated whether serum podocalyxin is altered prior to clinical presentation of preeclampsia. At 11 –13 weeks of gestation, serum podocalyxin was significantly elevated in women who subsequently developed preeclampsia. (Source: Placenta)
Source: Placenta - October 1, 2018 Category: Reproduction Medicine Authors: Mary Mansilla, Yao Wang, Jonathan Hyett, Fabricio da Silva Costa, Guiying Nie Source Type: research
Endogenous carbon monoxide production by menadione
Smokers have a significantly decreased risk of pre-eclampsia (PE), possibly attributed to an increase in blood carbon monoxide (CO) concentrations. At physiological concentrations, CO has been demonstrated to have placental vasodilatory and anti-inflammatory properties. Increasing endogenous CO production may have therapeutic potential to either prevent or treat PE. Menadione (MD), synthetic vitamin K3, increases CO in rat microsomes. Our objective was to investigate MD's ability to increase endogenous CO concentrations in pregnancy. (Source: Placenta)
Source: Placenta - September 28, 2018 Category: Reproduction Medicine Authors: Chioma U. Odozor, Nichole Peterson, Jessica Pudwell, Graeme N. Smith Source Type: research
Placental characteristics in monochorionic twins with selective intrauterine growth restriction in relation to the umbilical artery Doppler classification
The objective of this study was to evaluate the placental characteristics of monochorionic twin pregnancies with selective intrauterine growth restriction (sIUGR) classified according to the Gratac ós classification based on umbilical artery Doppler measurements. (Source: Placenta)
Source: Placenta - September 18, 2018 Category: Reproduction Medicine Authors: S.G. Groene, L.S.A. Tollenaar, F. Slaghekke, J.M. Middeldorp, M. Haak, D. Oepkes, E. Lopriore Source Type: research
Altered miRNA-4321 expression in maternal and foetal placenta of intrauterine growth restricted bovine foetuses
Intrauterine growth restriction (IUGR) is a serious pregnancy complication caused by placental insufficiency. We previously reported that truncation of MIMT1 gene exons 3 and 4 (MIMT1Del) causes IUGR in cattle. Here we investigated miRNA expression in the foetal and maternal placenta tissues of MIMT1Del/WT foetuses. Small RNA next generation sequencing and quantitative PCR revealed placental tissue-specific expression of the miR-4321, known to regulate many genes involved in early foetal development. (Source: Placenta)
Source: Placenta - September 16, 2018 Category: Reproduction Medicine Authors: Karolina Rutkowska, Monika Stachowiak, Jolanta Oprzadek, Stefan Bauersachs, Krzysztof Flisikowski Source Type: research
Genome-wide identification of enhancer elements in the placenta
Normal placental development is essential for a healthy pregnancy, and is contingent upon tight spatiotemporal regulation of gene expression. One level of transcriptional control is via enhancer elements in the genome. Enhancers are distal cis-regulatory elements that can impact gene expression regardless of their position or orientation. The study of enhancers in the placenta is usually focused on one or two at a time, and the simultaneous identification of all enhancers has been limited. However, such a holistic approach is necessary if we are to gain a systems-level understanding of gene expression regulation in the pla...
Source: Placenta - September 15, 2018 Category: Reproduction Medicine Authors: Majd Abdulghani, Ashish Jain, Geetu Tuteja Source Type: research
Placental vascularization indices and prediction of pre-eclampsia in high-risk women
To assess ability of first and second trimester Placental Vascularization Indices (PVIs) to predict pre-eclampsia (PE) in high-risk pregnancies. (Source: Placenta)
Source: Placenta - September 13, 2018 Category: Reproduction Medicine Authors: Kelly-Ann Eastwood, Alyson J. Hunter, Christopher C. Patterson, David R. Mc Cance, Ian S. Young, Valerie A. Holmes Source Type: research
Low expression of MFN2 is associated with early unexplained miscarriage by regulating autophagy of trophoblast cells
This study aims to investigate the roles of MFN2 and autophagy in early unexplained miscarriage. (Source: Placenta)
Source: Placenta - September 7, 2018 Category: Reproduction Medicine Authors: Hongcai Cai, Li Chen, Mengdi Zhang, Ping Su, Wenpei Xiang Source Type: research
The role of placental malperfusion in the pathogenesis of preeclampsia in dichorionic twin and singleton pregnancies
In singletons, the pathogenesis of hypertensive disorders of pregnancy (HDP) is attributed to abnormal placentation, characterized by maternal vascular malperfusion (MVM) lesions. Whether MVM plays a similar role in twin pregnancies is unclear. The purpose of the study was to compared placental pathology findings between dichorionic-twin and singleton pregnancies complicated by HDP. (Source: Placenta)
Source: Placenta - September 7, 2018 Category: Reproduction Medicine Authors: Amir Aviram, Ms Kristine Giltvedt, Christopher Sherman, John Kingdom, Arthur Zaltz, Jon Barrett, Nir Melamed Source Type: research
Placental metabolism and disease
The placenta is recognised as an organ that plays a vital role as a metabolic and a physical barrier in the foetoplacental unit. Several metabolic substrates and other molecules cross the placenta from the mother to the foetus and vice versa. This physiological phenomenon is considered as a mechanism of communication between the mother and the foetus. The exchange of metabolic signals between the mother and the foetus is mutually beneficial and secures the development and growth of the foetus as well as the wellbeing of the mother during and after pregnancy. (Source: Placenta)
Source: Placenta - September 6, 2018 Category: Reproduction Medicine Authors: Luis Sobrevia Tags: Editorial Source Type: research
Symposia abstracts
(Source: Placenta)
Source: Placenta - September 1, 2018 Category: Reproduction Medicine Source Type: research
Poster Abstracts
(Source: Placenta)
Source: Placenta - September 1, 2018 Category: Reproduction Medicine Source Type: research
Oral Presentation
(Source: Placenta)
Source: Placenta - September 1, 2018 Category: Reproduction Medicine Source Type: research
Title Page/Editorial Board
(Source: Placenta)
Source: Placenta - September 1, 2018 Category: Reproduction Medicine Source Type: research
IFPA Pages
(Source: Placenta)
Source: Placenta - September 1, 2018 Category: Reproduction Medicine Source Type: research
DNA methylation profile at a satellite region is associated with aberrant placentation in cloned calves
Cloning via somatic cell nuclear transfer (SCNT) has been associated with a variety of pathologies, primarily in the placenta, and these alterations may be associated with aberrant epigenetic reprogramming of the donor cell genome. We tested the hypothesis that DNA methylation patterns are not appropriately established after nuclear transfer and that those altered patterns are associated with specific aberrant phenotypes. (Source: Placenta)
Source: Placenta - August 29, 2018 Category: Reproduction Medicine Authors: M árcia Marques Silveira, Henrique Xavier Salgado Bayão, Anelise dos Santos Mendonça, Naiara Araújo Borges, Luna Nascimento Vargas, Alexandre Rodrigues Caetano, Rodolfo Rumpf, Maurício Machaim Franco Source Type: research
