Utility of metabolic profiling of serum in the diagnosis of pregnancy complications
Currently there are no clinical screening tests available to identify pregnancies at risk of developing preeclampsia (PET) and/or intrauterine growth restriction (IUGR), both of which are associated with abnormal placentation. Metabolic profiling is now a stable analytical platform used in many laboratories and has successfully been used to identify biomarkers associated with various pathological states. (Source: Placenta)
Source: Placenta - April 10, 2018 Category: Reproduction Medicine Authors: Katie L. Powell, Anthony Carrozzi, Alexandre S. Stephens, Vitomir Tasevski, Jonathan M. Morris, Anthony W. Ashton, Anthony C. Dona Source Type: research
Comparative study of regenerative effects of mesenchymal stem cells derived from placental amnion, chorion and umbilical cord on dermal wounds
Mesenchymal stem/stromal cells derived from human term placentas (PMSCs) are novel therapeutic agents and more topical than ever. Here we evaluated the effects of three types of PMSCs on wound healing in an in vivo mouse model: Amnion-derived MSCs (AMSCs), blood vessel-derived MSCs (BV-MSCs) from the chorionic plate and Wharton's jelly-derived MSCs (WJ-MSCs) from the umbilical cord. (Source: Placenta)
Source: Placenta - April 9, 2018 Category: Reproduction Medicine Authors: Juliane Ertl, Melanie Pichlsberger, Alexandru-Cristian Tuca, Paul Wurzer, Jakob Fuchs, Stefan H. Geyer, Barbara Maurer-Gesek, Wolfgang J. Weninger, Dagmar Pfeiffer, Vladimir Bubalo, Daryousch Parvizi, Lars-Peter Kamolz, Ingrid Lang Source Type: research
Gestational changes in PRMT1 expression of murine placentas
In mammals, the placenta is an organ that is required to maintain the development of fetus during pregnancy. Although the proper formation of placenta is in part regulated by the post-translational modifications of proteins, little is known regarding protein arginine methylation during placental development. Here, we characterized developmental expression of protein arginine methyltransferase 1 (PRMT1) in mouse placentas. (Source: Placenta)
Source: Placenta - April 7, 2018 Category: Reproduction Medicine Authors: Anna Sato, Jun-Dal Kim, Hayase Mizukami, Misaki Nakashima, Koichiro Kako, Junji Ishida, Atsuo Itakura, Satoru Takeda, Akiyoshi Fukamizu Source Type: research
A bioinformatics transcriptome meta-analysis highlights the importance of trophoblast differentiation in the pathology of hydatidiform moles
Hydatidiform mole (HM) is an aberrant human pregnancy with abnormal trophoblastic development, migration/invasion of the extravillous trophoblast in the decidua. These abnormalities are established in a hypoxic environment during the first trimester of gestation. (Source: Placenta)
Source: Placenta - April 7, 2018 Category: Reproduction Medicine Authors: Christophe Desterke, Rima Slim, Jean-Jacques candelier Source Type: research
Title Page/Editorial Board
(Source: Placenta)
Source: Placenta - April 1, 2018 Category: Reproduction Medicine Source Type: research
IFPA Pages
(Source: Placenta)
Source: Placenta - April 1, 2018 Category: Reproduction Medicine Source Type: research
Title Page/Editorial Board
(Source: Placenta)
Source: Placenta - April 1, 2018 Category: Reproduction Medicine Source Type: research
IFPA Pages
(Source: Placenta)
Source: Placenta - April 1, 2018 Category: Reproduction Medicine Source Type: research
Title Page/Editorial Board
(Source: Placenta)
Source: Placenta - April 1, 2018 Category: Reproduction Medicine Source Type: research
IFPA Pages
(Source: Placenta)
Source: Placenta - April 1, 2018 Category: Reproduction Medicine Source Type: research
DCE MRI reveals early decreased and later increased placenta perfusion after a stress challenge during pregnancy in a mouse model
Stress during pregnancy is known to have negative effects on fetal outcome. The purpose of this exploratory study was to examine placental perfusion alterations after stress challenge during pregnancy in a mouse model. (Source: Placenta)
Source: Placenta - March 31, 2018 Category: Reproduction Medicine Authors: Chressen Catharina Remus, Fabian Kording, Petra Arck, Emilia Solano, Jan Sedlacik, Gerhard Adam, Kurt Hecher, Nils Daniel Forkert Source Type: research
Gadd45a knockdown alleviates oxidative stress through suppressing the p38 MAPK signaling pathway in the pathogenesis of preeclampsia
Preeclampsia (PE) is a hypertensive disease associated with vascular oxidative stress (OS). Besides, cell response to OS triggers growth arrest and DNA damage inducible alpha (Gadd45a). Herein, we investigated the effect of Gadd45a on OS in PE. (Source: Placenta)
Source: Placenta - March 28, 2018 Category: Reproduction Medicine Authors: Fa-Hong Li, Na Han, Yong Wang, Qian Xu Source Type: research
Cadmium induces inflammatory cytokines through activating Akt signaling in mouse placenta and human trophoblast cells
Several reports demonstrated that cadmium (Cd) had proinflammatory activities. The present study aimed to investigate whether Cd induces inflammatory cytokines in mouse placenta and human trophoblast cells. (Source: Placenta)
Source: Placenta - March 28, 2018 Category: Reproduction Medicine Authors: Jun Hu, Hua Wang, Yong-Fang Hu, Xiao-Feng Xu, Yuan-Hua Chen, Mi-Zhen Xia, Cheng Zhang, De-Xiang Xu Source Type: research
Recombinant human soluble thrombomodulin as an anticoagulation therapy improves recurrent miscarriage and fetal growth restriction due to placental insufficiency – The leading cause of preeclampsia
Placental insufficiency is one of the major risk factors for growth restriction and preeclampsia. The aim of this study is to investigate whether recombinant human Thrombomodulin(r-TM) improves fetal conditions and physiological outcomes. (Source: Placenta)
Source: Placenta - March 26, 2018 Category: Reproduction Medicine Authors: Takumi Sano, Yoshito Terai, Atsushi Daimon, Misa Nunode, Yoko Nagayasu, Atsuko Okamoto, Daisuke Fujita, Masami Hayashi, Masahide Ohmichi Source Type: research
Investigating human placentation and pregnancy using first trimester chorionic villi
Chorionic villus sampling (CVS), routinely used for prenatal diagnosis of cytogenetic disorders, also possesses great potential for the study of placentation. To better understand villus biology, human placentation, and how these relate to pregnancy outcomes, we examined the morphology and transcriptomes of villi obtained via CVS from 10-14 weeks of pregnancy and correlated these with pregnancy attributes and clinical outcomes. First, we established a morphological scoring system based on three main villus features: branching, budding and vascularization. (Source: Placenta)
Source: Placenta - March 22, 2018 Category: Reproduction Medicine Authors: Roberta L. Hannibal, Margarida Cardoso Moreira, Shilpa P. Chetty, Joanne Lau, Zhongxia Qi, Eduardo Gonzalez-Maldonado, Athena M. Cherry, Jingwei Yu, Mary E. Norton, Julie C. Baker Source Type: research
