TGF- β1 inhibits human trophoblast cell invasion by upregulating cyclooxygenase-2
Enhanced expression and activity of cyclooxygenase-2 (COX-2) has been reported in trophoblasts from women with preeclampsia compared with healthy pregnant women. Prostaglandin E2, the production of which is initiated by COX-2, and transforming growth factor- β1 (TGF-β1) have been shown to inhibit human trophoblast cell invasion. However, it is not known if TGF-β1 induces COX-2 in human trophoblast cells or whether COX-2 mediates the suppressive effects of TGF-β1 on trophoblast invasion. (Source: Placenta)
Source: Placenta - July 2, 2018 Category: Reproduction Medicine Authors: Yuyin Yi, Jung-Chien Cheng, Christian Klausen, Peter C.K. Leung Source Type: research
Periodontal pathogens in the placenta and membranes in term and preterm birth
Preterm birth is a common cause of adverse neonatal and childhood outcomes. It is commonly associated with infection of the maternal-fetal interface. The relationship between periodontitis and preterm labour is controversial. (Source: Placenta)
Source: Placenta - July 2, 2018 Category: Reproduction Medicine Authors: Ruth McCuaig, Diana Wong, Fergus W. Gardiner, William Rawlinson, Jane E. Dahlstrom, Stephen Robson Source Type: research
Title Page/Editorial Board
(Source: Placenta)
Source: Placenta - June 26, 2018 Category: Reproduction Medicine Source Type: research
IFPA Pages
(Source: Placenta)
Source: Placenta - June 26, 2018 Category: Reproduction Medicine Source Type: research
Expression of glucose transporters in the endometrium and early conceptus membranes of the horse
Glucose is the primary energy substrate for early conceptus development and, for the first 40 days of gestation, the equine conceptus depends solely on glucose available in the histotroph; thereafter, histotrophic glucose provision continues to support transport across the definitive placenta. (Source: Placenta)
Source: Placenta - June 25, 2018 Category: Reproduction Medicine Authors: Charlotte Gibson, Marta de Ruijter-Villani, Jolanda Rietveld, Tom A.E. Stout Source Type: research
Effect of Tetrabromobisphenol A on expression of biomarkers for inflammation and neurodevelopment by the placenta
Polybrominated diphenyl ethers (PBDEs) enhance basal and bacteria-stimulated production of proinflammatory cytokines by the placenta and may also increase the risk of preterm birth and neurodevelopmental disorders. Whether or not other brominated flame retardants such as Tetrabromobisphenol A (TBBPA) have similar properties is unclear. Therefore, we evaluated the effects of TBBPA on the production of steroids, as well as biomarkers for inflammation, oxidative stress, and neurodevelopment by the placenta. (Source: Placenta)
Source: Placenta - June 20, 2018 Category: Reproduction Medicine Authors: Yuko Arita, Matthew Pressman, Darios Getahun, Ramkumar Menon, Morgan R. Peltier Source Type: research
Effect of tetrabromo-bisphenol a on expression of biomarkers for inflammation and neurodevelopment by the placenta
Polybrominated diphenyl ethers (PBDEs) enhance basal and bacteria-stimulated production of proinflammatory cytokines by the placenta and may also increase the risk of preterm birth and neurodevelopmental disorders. Whether or not other brominated flame retardants such as Tetrabromobisphenol A (TBBPA) have similar properties is unclear. Therefore, we evaluated the effects of TBBPA on the production of steroids, as well as biomarkers for inflammation, oxidative stress, and neurodevelopment by the placenta. (Source: Placenta)
Source: Placenta - June 20, 2018 Category: Reproduction Medicine Authors: Yuko Arita, Matthew Pressman, Darios Getahun, Ramkumar Menon, Morgan R. Peltier Source Type: research
In an in-vitro model using human fetal membranes, α-lipoic acid inhibits inflammation induced fetal membrane weakening
We established an in-vitro model for the study of human fetal membrane (FM) weakening leading to pPROM. In this model, granulocyte-macrophage colony-stimulating factor (GM-CSF) is a critical intermediate for both tumor necrosis factor- α (TNF; modeling infection/inflammation) and thrombin (modeling decidual bleeding/abruption)-induced weakening. Thus, inhibitors of FM weakening can be categorized as targeting GM-CSF production, GM-CSF downstream action, or both. Most progestogens inhibit both, except 17-α hydroxyprogesterone cap roate which inhibits FM weakening at only one point, GM-CSF production. (Source: Placenta)
Source: Placenta - June 19, 2018 Category: Reproduction Medicine Authors: Deepak Kumar, Robert M. Moore, Anudeepa Sharma, Brian M. Mercer, Joseph M. Mansour, John J. Moore Source Type: research
Evidence of oxidative stress-induced senescence in mature, post-mature and pathological human placentas
We examined senescence markers across normal gestation, and in pathological and post-mature pregnancies. Inducers of oxidative stress were used to mimic senescence changes in term explants. (Source: Placenta)
Source: Placenta - June 19, 2018 Category: Reproduction Medicine Authors: Tereza Cindrova-Davies, Norah M.E. Fogarty, Carolyn J.P. Jones, John Kingdom, Graham J. Burton Source Type: research
Immunomodulatory effects of human amniotic epithelial cells on naive CD4+ T cells from women with unexplained recurrent spontaneous abortion
Immune imbalance at the maternal-fetal interface plays a fundamental role in the pathogenesis of unexplained recurrent spontaneous abortion (URSA). Human amniotic epithelial cells (hAECs) possess pregnancy-friendly immunomodulatory effects. Here, we investigated how function of naive CD4+ T cells from URSA patients is affected by hAECs. (Source: Placenta)
Source: Placenta - June 16, 2018 Category: Reproduction Medicine Authors: Hossein Motedayyen, Amir-Hassan Zarnani, Nader Tajik, Somayeh Ghotloo, Abbas Rezaei Source Type: research
The DNA-hydrolyzing activity of IgG antibodies from human placenta
Since during pregnancy and lactation women tend to develop autoimmune processes, characterization of placenta immunoglobulins and their possible catalytic functions is a very important step towards understanding the function of placenta. (Source: Placenta)
Source: Placenta - June 15, 2018 Category: Reproduction Medicine Authors: Evgenii A. Lekchnov, Pavel S. Dmitrenok, Ol'ga D. Zakharova, Sergey E. Sedykh, Valentina N. Buneva, Georgy A. Nevinsky Source Type: research
Geometric and hemodynamic characterization of uterine spiral arteries: The concept of resistance reserve
The coiled geometry of spiral arteries in the human uteroplacental circulation is a hemodynamic enigma because of added length of a spiral artery compared with that of a straight artery, as well as added complexity of the flow within the vessel because of the coiling curvature. (Source: Placenta)
Source: Placenta - June 12, 2018 Category: Reproduction Medicine Authors: Mair Zamir, D. Michael Nelson, Yehuda Ginosar Source Type: research
Subclinical and clinical chorioamnionitis, fetal vasculitis, and risk for preterm birth: A cohort study
To evaluate the association between subclinical and clinical chorioamnionitis and risk of preterm birth (PTB). (Source: Placenta)
Source: Placenta - June 5, 2018 Category: Reproduction Medicine Authors: Kristin Palmsten, Katharine K. Nelson, Louise C. Laurent, Soojin Park, Christina D. Chambers, Mana M. Parast Source Type: research
Title Page/Editorial Board
(Source: Placenta)
Source: Placenta - June 1, 2018 Category: Reproduction Medicine Source Type: research
IFPA Pages
(Source: Placenta)
Source: Placenta - June 1, 2018 Category: Reproduction Medicine Source Type: research
