In an in-vitro model using human fetal membranes, α-lipoic acid inhibits inflammation induced fetal membrane weakening

We established an in-vitro model for the study of human fetal membrane (FM) weakening leading to pPROM. In this model, granulocyte-macrophage colony-stimulating factor (GM-CSF) is a critical intermediate for both tumor necrosis factor- α (TNF; modeling infection/inflammation) and thrombin (modeling decidual bleeding/abruption)-induced weakening. Thus, inhibitors of FM weakening can be categorized as targeting GM-CSF production, GM-CSF downstream action, or both. Most progestogens inhibit both, except 17-α hydroxyprogesterone cap roate which inhibits FM weakening at only one point, GM-CSF production.

Source: Placenta - June 19, 2018 Category: Reproduction Medicine Authors: Deepak Kumar, Robert M. Moore, Anudeepa Sharma, Brian M. Mercer, Joseph M. Mansour, John J. Moore Source Type: research