Placental leptin expression is mediated by NF κB signaling
Leptin is a key hormone in placental physiology. Previous results demonstrated that estradiol (E2) regulates leptin expression involving genomic and non-genomic effects. (Source: Placenta)
Source: Placenta - February 1, 2018 Category: Reproduction Medicine Authors: M. Schanton, A. P érez-Pérez, Y. Gambino, B. Maskin, V. Sánchez-Margalet, C. Varone Source Type: research
Title Page/Editorial Board
(Source: Placenta)
Source: Placenta - February 1, 2018 Category: Reproduction Medicine Source Type: research
IFPA Pages
(Source: Placenta)
Source: Placenta - February 1, 2018 Category: Reproduction Medicine Source Type: research
Corrigendum to “Identification of potential early biomarkers of preeclampsia” [Placenta (2018) 61–71]
The authors regret that the Results section of the article contains an error. The paragraph should be read as below: (Source: Placenta)
Source: Placenta - January 22, 2018 Category: Reproduction Medicine Authors: Angelika V. Timofeeva, Vladyslava A. Gusar, Nataliya E. Kan, Kseniya N. Prozorovskaya, Anna O. Karapetyan, Oleg R. Bayev, Vitaliy V. Chagovets, Sergei F. Kliver, Daria Yu. Iakovishina, Vladimir E. Frankevich, Gennadiy T. Sukhikh Source Type: research
Oxidative stress induces senescence and sterile inflammation in murine amniotic cavity
A physiologic increase of reactive oxygen species (ROS) is observed through pregnancy. ROS-induced damage to major cellular elements, specifically protein peroxidation, can lead to fetal and placental tissue senescence and inflammation often associated with normal parturition. The purpose of this study was to examine the effects of oxidative stress (OS) in inducing changes in proteins, senescence, and sterile inflammation in pregnant mice. (Source: Placenta)
Source: Placenta - January 21, 2018 Category: Reproduction Medicine Authors: Jossimara Polettini, Lauren S. Richardson, Ramkumar Menon Source Type: research
Pregestational diabetes increases fetoplacental vascular resistance in rats
Diabetes is a well-known risk factor in pregnancy. Because maternal diabetes involves oxidative stress that is also induced by chronic hypoxia and can alter vascular function, we sought to determine the effects of chronic maternal hyperglycemia on the fetoplacental vasculature in rats and to compare it with the effects of chronic hypoxia. (Source: Placenta)
Source: Placenta - January 19, 2018 Category: Reproduction Medicine Authors: Olga Vajnerova, Petr Kafka, Tereza Kratzerova, Karel Chalupsk ý, Vaclav Hampl Source Type: research
IFPA meeting 2017
The 2017 meeting of the International Federation of Placenta Associations (IFPA 2017) was organized by the European Placenta Group and was held in Manchester, UK. Manchester is one of only a handful of cities to have hosted the meeting twice, the first time was nearly a quarter of a century ago and in that time, not only has the membership of the Local Organising Committee evolved and ‘matured’, but so too has the city and, of course, our understanding of the placenta's vital role in setting an individual's health trajectory. (Source: Placenta)
Source: Placenta - January 17, 2018 Category: Reproduction Medicine Authors: Melissa Westwood, the IFPA 2017 Local Organising Committee Source Type: research
Knowledge needed about the exchange physiology of the placenta
There is now a basic understanding of the driving forces and mechanisms underlying rates of solute exchange across the placenta but there are still major gaps in knowledge. Here we summarise this basic understanding, whilst highlighting gaps in knowledge. We then focus on two particular areas where more knowledge is needed: (1) the electrical potential difference (PD) across the placenta and (2) the paracellular permeability of the placenta to hydrophilic solutes.In many species a PD has been recorded between a catheter in a maternal blood vessel and one in a fetal vessel. (Source: Placenta)
Source: Placenta - January 15, 2018 Category: Reproduction Medicine Authors: Colin P. Sibley, Paul Brownbill, Jocelyn D. Glazier, Susan L. Greenwood Source Type: research
Regulating needs: Exploring the role of insulin-like growth factor-2 signalling in materno-fetal resource allocation
During pregnancy, the fetus requires nutrients supplied by the mother to grow and develop. However, the mother also requires sufficient resources to support the pregnancy, as well as, to maintain her health. Failure to regulate resource allocation between the mother and fetus can lead to pregnancy complications with immediate and life-long consequences for maternal and offspring health. This review explores the role of insulin-like growth factor (IGF)-2 in regulating materno-fetal resource allocation, particularly via its regulation of placental development and function. (Source: Placenta)
Source: Placenta - January 11, 2018 Category: Reproduction Medicine Authors: Amanda Nancy Sferruzzi-Perri Source Type: research
Soluble ST2, a preeclampsia-related cytokine receptor, is transported bi-directionally across the placenta
We aimed to elucidate whether soluble ST2 (sST2), a preeclampsia (PE)-related cytokine, in the maternal or fetal circulation could be transported to the other circulatory system across the placenta. (Source: Placenta)
Source: Placenta - January 9, 2018 Category: Reproduction Medicine Authors: Weiqi Kong, Yunhui Gong, Rong Zhou, Yanyun Wang, Yanping Zhang, Xiaolei Luo, Lin Zhang, Tao Wang Source Type: research
Placental control of metabolic adaptations in the mother for an optimal pregnancy outcome. What goes wrong in gestational diabetes?
As pregnancy progresses the placental syncytiotrophoblast increasingly assumes control of maternal glucose homeostasis through the release and counter-balancing effects of placental lactogen (PL) and placental variant growth hormone (GH-V). While local actions of these hormones on placental growth and function are likely to exist, each also exerts indirect actions to ensure fetal nutritional availability through modulation of the maternal insulin/insulin-like growth factor axis. Peripheral insulin resistance results from the increasing levels of GH-V in the maternal circulation and is counter-balanced by an increase in ins...
Source: Placenta - January 8, 2018 Category: Reproduction Medicine Authors: David J. Hill Source Type: research
