Associations between fetal size, sex and both proliferation and apoptosis at the porcine feto-maternal interface
Inadequate fetal growth has severe consequences for both neonatal and adult development. It is hypothesized that the feto-maternal interface associated with the lightest and male fetuses will undergo more apoptosis and less proliferation than those supplying the closest to mean litter weight (CTMLW) and female fetuses respectively. (Source: Placenta)
Source: Placenta - August 27, 2018 Category: Reproduction Medicine Authors: Claire Stenhouse, Charis O. Hogg, Cheryl J. Ashworth Source Type: research
FMS-like tyrosine kinase 1 (FLT1) is a key regulator of fetoplacental endothelial cell migration and angiogenesis
Fetoplacental angiogenesis plays a vital role in pregnancy outcome. Vascular endothelial growth factor A (VEGFA) is one major regulator of angiogenesis. It primarily binds to FMS-like tyrosine kinase (FLT1) and kinase insert domain receptor (KDR). In most vascular beds, KDR appears to be the main mediator of angiogenesis. However, the role of both receptors within the human placenta remains unknown. (Source: Placenta)
Source: Placenta - August 20, 2018 Category: Reproduction Medicine Authors: Shuhan Ji, Hong Xin, Yingchun Li, Emily J. Su Source Type: research
TEMPORARY REMOVAL: Chorion laeve accreta – Another manifestation of morbid adherence
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. (Source: Placenta)
Source: Placenta - August 17, 2018 Category: Reproduction Medicine Authors: T.Y. Khong, S.F. Cramer, D.S. Heller Source Type: research
TEMPORARY REMOVAL: Chorion laeve accreta-Another manifestation of morbid adherence
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. (Source: Placenta)
Source: Placenta - August 17, 2018 Category: Reproduction Medicine Authors: T.Y. Khong, S.F. Cramer, D.S. Heller Source Type: research
Fractal dimensions and branching characteristics of placental chorionic surface arteries
We present a novel approach to characterize and compare the placental chorionic surface arteries (PCSA) of normal, preterm, diabetic and preeclamptic pregnancies using their fractal dimension (FD) and branch point number (BPN). Mean FD of PCSA of normal pregnancies was similar to those of diabetic and preeclamptic pregnancies, but significantly different from those of preterm pregnancies. In contrast, the BPN of PCSA of normal and preterm pregnancies was similar but significantly different from diabetic and preeclamptic pregnancies. (Source: Placenta)
Source: Placenta - August 17, 2018 Category: Reproduction Medicine Authors: R.G. Shah, T. Girardi, X. Ma, C.M. Salafia Tags: Technical note Source Type: research
Chorion laeve accreta – Another manifestation of morbid adherence
Smooth muscle in the decidua of fetal membranes (membrane myofibers, MMF) is not mentioned in standard textbooks. (Source: Placenta)
Source: Placenta - August 17, 2018 Category: Reproduction Medicine Authors: T.Y. Khong, S.F. Cramer, D.S. Heller Source Type: research
Increased mitochondrial DNA copy number in maternal peripheral blood is associated with low birth weight in Lombok, Indonesia
Fetal development depends on maternal metabolic energy from mitochondria. We investigated the association of maternal mitochondrial function, represented by mitochondrial DNA copy number (mtDNA-CN) of venous blood, with child birth weight (BW) from 528 randomly selected mothers enrolled in the Supplementation with Multiple Micronutrients Intervention Trial (ISRCTN 34151616). Real-time quantitative PCR of archived blood specimens and regression analysis adjusting for other primary determinants of BW showed that loge mtDNA-CN was inversely associated with BW ( β = −204.6, p (Source: Placenta)
Source: Placenta - August 9, 2018 Category: Reproduction Medicine Authors: L. Priliani, C.A. Febinia, B. Kamal, A.H. Shankar, S.G. Malik Tags: Short communication Source Type: research
Race and risk of maternal vascular malperfusion lesions in the placenta
The biological mechanisms that underlie racial disparities in placenta-mediated pregnancy complications remain unknown. Placental evidence of maternal vascular malperfusion (MVM), a common pathologic feature of these outcomes, represents hypoxic-ischemic damage to the placenta. We sought to separately estimate the risk of MVM and individual lesions associated with maternal race. (Source: Placenta)
Source: Placenta - August 2, 2018 Category: Reproduction Medicine Authors: Vanessa Assibey-Mensah, W. Tony Parks, Alison D. Gernand, Janet M. Catova Source Type: research
Evaluating maternal hyperglycemic exposure and fetal placental arterial dysfunction in a dual cotyledon, dual perfusion model
Gestational diabetes affects almost 1 in 10 pregnancies and is associated with adverse outcomes including fetal demise. Pregnancy complications related to diabetes are attributed to placental vascular dysfunction. With diabetes, maternal hyperglycemia is thought to promote placental vasoconstriction. However, it remains poorly understood if and how hyperglycemia leads to placental vascular dysfunction or if humoral factors related to maternal diabetes are responsible. (Source: Placenta)
Source: Placenta - August 1, 2018 Category: Reproduction Medicine Authors: Luckey C. Reed, Estrada M. Sarah, Robert B. Walton, Peter G. Napolitano, Nicholas Ieronimakis Source Type: research
Real-time microscopic assessment of fatty acid uptake kinetics in the human term placenta
The placenta employs an efficient and selective fatty acid transport system to supply lipids for fetal development. Disruptions in placental fatty acid transport lead to restricted fetal growth along with cardiovascular and neurologic deficits. Nevertheless, little is known about the molecular mechanisms involved in human placental fatty acid trafficking during the initial steps of uptake, or the importance of fatty acid chain length in determining uptake rates. (Source: Placenta)
Source: Placenta - August 1, 2018 Category: Reproduction Medicine Authors: Kevin S. Kolahi, Amy Valent, Kent L. Thornburg Source Type: research
Maternal obesity is not associated with placental lipid accumulation in women with high omega-3 fatty acid levels
Placentas of obese women have higher lipid content compared to lean women. We have previously shown that supplementation of overweight and obese women with omega-3 fatty acids decreases placental esterification pathways and total lipid content in a mid-western population (Ohio). We hypothesized that placental lipid accumulation and inflammation would be similar between lean and obese women living in a region of high omega-3 intake, such as Hawaii. (Source: Placenta)
Source: Placenta - July 30, 2018 Category: Reproduction Medicine Authors: Fernanda L. Alvarado, Virtu Calabuig-Navarro, Maricela Haghiac, Michelle Puchowicz, Pai-Jong S. Tsai, Perrie O'Tierney-Ginn Source Type: research
Comparison of diameter-based and image-based measures of surface area from gross placental pathology for use in epidemiologic studies
Placental surface area is often estimated using diameter measurements. However, as many placentas are not elliptical, we were interested in the validity of these estimates. We compared placental surface area from images for 491 singletons from the Stillbirth Collaborative Research Network (SCRN) Study (416 live births, 75 stillbirths) to estimates obtained using diameter measurements. Placental images and diameters were obtained from pathologic assessments conducted for the SCRN Study and images were analyzed using ImageJ software. (Source: Placenta)
Source: Placenta - July 27, 2018 Category: Reproduction Medicine Authors: Alexa A. Freedman, Lauren M. Kipling, Katie Labgold, Carmen J. Marsit, Carol J. Hogue, Augustine Rajakumar, Alicia K. Smith, Halit Pinar, Deborah L. Conway, Radek Bukowski, Michael W. Varner, Robert L. Goldenberg, Donald J. Dudley, Carolyn Drews-Botsch Tags: Technical note Source Type: research
Title Page/Editorial Board
(Source: Placenta)
Source: Placenta - July 26, 2018 Category: Reproduction Medicine Source Type: research
IFPA Pages
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Source: Placenta - July 26, 2018 Category: Reproduction Medicine Source Type: research
Corrigendum to ‘Genetic and microscopic assessment of the human chemotherapy-exposed placenta reveals possible pathways contributive to fetal growth restriction’[YPLAC 64C (2018) 61–70]
The authors regret that the funding part states an incorrect grant number of the CRADLE consolidator grant, granted by the European Research Council. The official and correct grant number is: 647047. (Source: Placenta)
Source: Placenta - July 24, 2018 Category: Reproduction Medicine Authors: M. Verheecke, A. Cort ès Calabuig, J. Finalet Ferreiro, V. Brys, R. Van Bree, G. Verbist, T. Everaert, L. Leemans, M.M. Gziri, I. Boere, M.J. Halaska, J. Van Houdt, F. Amant, K. Van Calsteren Source Type: research
