DNA methylation profile at a satellite region is associated with aberrant placentation in cloned calves

Cloning via somatic cell nuclear transfer (SCNT) has been associated with a variety of pathologies, primarily in the placenta, and these alterations may be associated with aberrant epigenetic reprogramming of the donor cell genome. We tested the hypothesis that DNA methylation patterns are not appropriately established after nuclear transfer and that those altered patterns are associated with specific aberrant phenotypes.

Source: Placenta - August 29, 2018 Category: Reproduction Medicine Authors: M árcia Marques Silveira, Henrique Xavier Salgado Bayão, Anelise dos Santos Mendonça, Naiara Araújo Borges, Luna Nascimento Vargas, Alexandre Rodrigues Caetano, Rodolfo Rumpf, Maurício Machaim Franco Source Type: research