Proteomics and bioinformatics analysis of altered protein expression in the placental villous tissue from early recurrent miscarriage patients

Recurrent miscarriage (RM) affects 5% of women, it has an adverse emotional impact on women. Because of the complexities of early development, the mechanism of recurrent miscarriage is still unclear. We hypothesized that abnormal placenta leads to early recurrent miscarriage (ERM). The aim of this study was to identify ERM associated factors in human placenta villous tissue using proteomics. Investigation of these differences in protein expression in parallel profiling is essential to understand the comprehensive pathophysiological mechanism underlying recurrent miscarriage (RM).

Source: Placenta - November 4, 2017 Category: Reproduction Medicine Authors: Hai-Tao Pan, Hai-Gang Ding, Min Fang, Bin Yu, Yi Cheng, Ya-Jing Tan, Qi-Qin Fu, Bo Lu, Hong-Guang Cai, Xin Jin, Xian-Qing Xia, Tao Zhang Source Type: research