Journal of the Renin-Angiotensin-Aldosterone System : JRAAS This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The effects of telmisartan on the nuclear factor of activated T lymphocytes signalling pathway in hypertensive patients
Conclusions: Antihypertensive function and inhibitory effects of telmisartan on the T lymphocyte NFAT signalling pathway are unlikely to affect the normal immune function of hypertensive patients. Telmisartan may exert anti-inflammatory effects by inhibition of the NFAT signalling pathway in the T lymphocytes of hypertensive patients. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 16, 2016 Category: Biomedical Science Authors: Huang, S.-S., He, S.-L., Zhang, Y.-M. Tags: Original Article Source Type: research

Budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme upon high-altitude exposure
Conclusions: Upon acute high-altitude exposure, budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 16, 2016 Category: Biomedical Science Authors: Li, H.-J., Zheng, C.-R., Chen, G.-Z., Qin, J., Zhang, J.-H., Yu, J., Zhang, E.-H., Huang, L. Tags: Original Article Source Type: research

No association of adiponectin +45 T/G polymorphism with the risk of gestational diabetes mellitus: Evidence from a meta-analysis
Conclusions: This meta-analysis provides evidence that the ADIPOQ +45 T/G polymorphism was not related to the risk of GDM. Further multicenter, prospective studies with larger sample size would be valuable to confirm the result. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 11, 2016 Category: Biomedical Science Authors: Xu, F., Zhang, H., Qi, H. Tags: Original Article Source Type: research

Addition of hydrochlorothiazide to angiotensin receptor blocker therapy can achieve a lower sodium balance with no acceleration of intrarenal renin angiotensin system in patients with chronic kidney disease
Conclusions: Lower Na balance was produced by add-on HCTZ to ARB treatment without an increase of intra-renal renin-angiotensin system activity, leading to restoration of nocturnal hypertension. A further study is needed to demonstrate that the reduction of UAGTV by additional diuretics to ARBs prevents the progression of nephropathy or cardiovascular events. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 8, 2016 Category: Biomedical Science Authors: Fuwa, D., Fukuda, M., Ogiyama, Y., Sato, R., Mizuno, M., Miura, T., Abe-Dohmae, S., Michikawa, M., Kobori, H., Ohte, N. Tags: Original Article Source Type: research

Feasibility of fluorescence energy transfer system for imaging the renoprotective effects of aliskiren in diabetic mice
Conclusion: Fluorescence resonance energy transfer could provide a new tool for evaluating tissue and plasma enzymatic activity. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - May 22, 2016 Category: Biomedical Science Authors: Kidokoro, K., Satoh, M., Itano, S., Kuwabara, A., Sasaki, T., Kashihara, N. Tags: Original Article Source Type: research

Plasma oxidative stress level of IgA nephropathy in children and the effect of early intervention with angiotensin-converting enzyme inhibitors
Conclusions: The children with IgAN had an increase in the plasma level of oxidative stress, expressed as an increased plasma level of AOPP and MDA and a decreased plasma level of SOD. Oxidative stress was associated with the progression of IgAN in children. Early treatment with ACEI therapy can significantly reduce the plasma level of oxidative stress in children with IgAN. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - May 17, 2016 Category: Biomedical Science Authors: Pei, Y., Xu, Y., Ruan, J., Rong, L., Jiang, M., Mo, Y., Jiang, X. Tags: Original Article Source Type: research

Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats
Angiotensin converting enzyme inhibitors and propofol both exert hypotensive action and may affect hemostasis. We investigated the influence of quinapril and propofol on hemodynamics and hemostasis in renal-hypertensive rats with induced arterial thrombosis. Two-kidney, one clip hypertensive rats were treated with quinapril (3.0 mg/kg for 10 days), and then received propofol infusion (15 mg/kg/h) during ongoing arterial thrombosis. The hemodynamic and hemostatic parameters were assayed. Quinapril exerted a hypotensive effect increasing after propofol infusion. Quinapril showed an antithrombotic effect with the platelet adh...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - May 10, 2016 Category: Biomedical Science Authors: Wojewodzka-Zelezniakowicz, M., Kisiel, W., Kramkowski, K., Gromotowicz-Poplawska, A., Zakrzeska, A., Stankiewicz, A., Kolodziejczyk, P., Szemraj, J., Ladny, J. R., Chabielska, E. Tags: Original Article Source Type: research

Treatment with irbesatan may improve slit diaphragm alterations in rats with adriamycin-induced nephropathy
Conclusions: For rats with adriamycin-induced nephropathy, irbesartan could significantly reduce proteinuria. As a possible mechanism, irbesartan may improve the slit diaphragm protein of the glomerular podocyte and stabilize the cytoskeleton of the podocyte. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - May 10, 2016 Category: Biomedical Science Authors: Wang, N., Wei, R.-b., Li, P., Li, Q.-p., Yang, X., Yang, Y., Huang, M.-j., Wang, R., Yin, Z., Lv, Y., Chen, X.-m. Tags: Original Article Source Type: research

Gender difference in the response to valsartan/amlodipine single-pill combination in essential hypertension (China Status II): An observational study
Conclusions: Gender might be a factor for consideration in the decision-making process of individualised antihypertensive therapy, in the future. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - April 27, 2016 Category: Biomedical Science Authors: Wang, H., Chen, H. Tags: Original Article Source Type: research

Fructose-rich diet induces gender-specific changes in expression of the renin-angiotensin system in rat heart and upregulates the ACE/AT1R axis in the male rat aorta
Conclusions: The FRD induced gender-specific changes in the expression of the RAS in the heart and aortae of male rats. Further investigations are required in order to get a comprehensive understanding of the underlying mechanisms of gender-specific fructose-induced cardiovascular pathologies. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - April 26, 2016 Category: Biomedical Science Authors: Bundalo, M. M., Zivkovic, M. D., Romic, S. D., Tepavcevic, S. N., Koricanac, G. B., Djuric, T. M., Stankovic, A. D. Tags: Original Article Source Type: research

L/T-type calcium channel blocker reduces non-Gaussianity of heart rate variability in chronic kidney disease patients under preceding treatment with ARB
Conclusions: Reduction of 25s is useful to assess the effect of sympathoinhibitory treatment. Further studies are needed to investigate if the restoration of HRV is directly associated with the improvement of prognosis in patients with CKD. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - April 17, 2016 Category: Biomedical Science Authors: Fukuda, M., Ogiyama, Y., Sato, R., Miura, T., Fukuta, H., Mizuno, M., Kiyono, K., Yamamoto, Y., Hayano, J., Ohte, N. Tags: Original Article Source Type: research

Increased vascular sympathetic modulation in mice with Mas receptor deficiency
Conclusions: The deletion of Mas receptor is associated with an increase of SAP and with an increased BPV, indicating alterations in autonomic control. Increase of sympathetic vascular modulation in absence of Mas evidences the important role of Ang-(1–7)/Mas on cardiovascular regulation. Moreover, the absence of significant changes in HR and HRV can indicate an adaptation of autonomic cardiac balance. Our results suggest that the Ang-(1–7)/Mas axis seems more important in autonomic modulation of arterial pressure than HR. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - April 12, 2016 Category: Biomedical Science Authors: Rabello Casali, K., Ravizzoni Dartora, D., Moura, M., Bertagnolli, M., Bader, M., Haibara, A., Alenina, N., Irigoyen, M. C., Santos, R. A. Tags: Original Article Source Type: research

Evaluation of subacute change in RAAS activity (as indicated by urinary aldosterone:creatinine, after pharmacologic provocation) and the response to ACE inhibition
Conclusion: Increases in UAldo:C, despite ACEI administration, is evidence of IRB in this subacute model of experimental RAAS activation and suppression. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 22, 2016 Category: Biomedical Science Authors: Ames, M. K., Atkins, C. E., Lantis, A. C., zum Brunnen, J. Tags: Original Article Source Type: research

Association of aldosterone synthase (CYP11B2) -344 T/C polymorphism with diabetic nephropathy: A meta-analysis
Conclusions: Our meta-analysis indicates that aldosterone synthase (CYP11B2) gene polymorphism may contribute to diabetic nephropathy development, especially in Asian group, with the T allele acting as a risk factor. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 22, 2016 Category: Biomedical Science Authors: Xu, H., Wang, X., Liu, M., Shao, X., He, X. Tags: Original Article Source Type: research

Comparison of the relative importance of vascular and plasma drug concentrations to the hypotensive effect of telmisartan in rats
Conclusion: The vascular drug concentration, not the plasma drug concentration, may be related to the hypotensive effect after administration of telmisartan. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 22, 2016 Category: Biomedical Science Authors: Takai, S., Sakonjo, H., Jin, D. Tags: Original Article Source Type: research