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Renin-angiotensin system gene expression and neurodegenerative diseases
Conclusions: To date, no single nucleotide polymorphisms in components of the RAS can be definitively linked to the neurodegenerative diseases evaluated in this study. However, altered gene expression of several components of the RAS is associated with several neurodegenerative diseases, which may indicate that the RAS contributes to the pathology of these diseases. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 8, 2016 Category: Biomedical Science Authors: Goldstein, B., Speth, R. C., Trivedi, M. Tags: Original Article Source Type: research

Aldosterone/direct renin concentration ratio as a screening test for primary aldosteronism: A meta-analysis
Conclusions: This study demonstrates the efficacy of ADRR as a screening test for PA. However, as antihypertensive drugs can interfere with the interpretation of ADRR, it is recommended to interrupt therapy or at least replace with analogues that do not significantly affect the ADRR value. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 16, 2016 Category: Biomedical Science Authors: Li, X., Goswami, R., Yang, S., Li, Q. Tags: Original Article Source Type: research

Increased renal apoptosis and reduced renin-angiotensin system in fetal growth restriction
Conclusion: Renal apoptosis might contribute to the reduction of nephrons, and ultrasound plays a vital role in early diagnosis of developmental origins of health and disease (DOHAD). (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 16, 2016 Category: Biomedical Science Authors: Wang, Y. P., Chen, X., Zhang, Z. K., Cui, H. Y., Wang, P., Wang, Y. Tags: Original Article Source Type: research

Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury
Conclusion: This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR and increases the deleterious ACE/Ang II/AT1R axis of the renal RAS in mice. Further, AT2KO mice are more susceptible to HFD-induced renal injury. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 4, 2016 Category: Biomedical Science Authors: Ali, Q., Dhande, I., Samuel, P., Hussain, T. Tags: Original Article Source Type: research

miR-205 mediates the inhibition of cervical cancer cell proliferation using olmesartan
Conclusion: This result provides a new idea on the anti-tumor mechanism of olmesartan, which may be used as a novel therapeutic target of cervical cancer. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 2, 2016 Category: Biomedical Science Authors: Yue, Z., Yun-shan, Z., Feng-xia, X. Tags: Original article Source Type: research

Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke
Levels of angiotensin converting enzyme 2 (ACE2), a cardio and neuro-protective carboxypeptidase, are dynamically altered after stroke in preclinical models. We sought to characterize the previously unexplored changes in serum ACE2 activity of stroke patients and the mechanism of these changes. Serum samples were obtained from patients during acute ischemic stroke (n=39), conditions mimicking stroke (stroke-alert, n=23), or from control participants (n=20). Enzyme activity levels were analyzed by fluorometric assay and correlated with clinical variables by regression analyses. Serum ACE2 activity was significantly lower in...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 2, 2016 Category: Biomedical Science Authors: Bennion, D. M., Rosado, C. A., Haltigan, E. A., Regenhardt, R. W., Sumners, C., Waters, M. F. Tags: Original Article Source Type: research

Angiotensin II Type 1 receptor (AGTR1) gene polymorphisms are associated with vascular manifestations in patients with systemic sclerosis (SSc)
Conclusions: This is the first report of the association of these polymorphisms with vasculopathy in Mexican admixed SSc patients. Our findings suggested that the angiotensin II Type 1 receptor genotype may influence the clinical expression of vasculopathy in these patients. Functional analyses should follow. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 2, 2016 Category: Biomedical Science Authors: Rodriguez-Reyna, T. S., Nunez-Alvarez, C., Cruz-Lagunas, A., Posadas-Sanchez, R., Perez-Hernandez, N., Jimenez-Alvarez, L., Ramirez-Martinez, G., Granados, J., Vargas-Alarcon, G., Zuniga, J. Tags: Original Article Source Type: research

Prevention of microalbuminuria using early intervention with renin-angiotensin system inhibitors in patients with type 2 diabetes: A systematic review
Conclusions: We conclude that in patients with type 2 diabetes and normoalbuminuria, early intervention with ACEis or ARBs reduces the risk for development of microalbuminuria. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 2, 2016 Category: Biomedical Science Authors: Persson, F., Lindhardt, M., Rossing, P., Parving, H.-H. Tags: Original Article Source Type: research

Renal sodium transport in renin-deficient Dahl salt-sensitive rats
Conclusion: These data illustrate that renin deficiency leads to significant dysregulation of ion transporters. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - July 20, 2016 Category: Biomedical Science Authors: Pavlov, T. S., Levchenko, V., Ilatovskaya, D. V., Moreno, C., Staruschenko, A. Tags: Original Article Source Type: research

Imbalance between angiotensin II and angiotensin-(1-7) in human coronary atherosclerosis
Conclusion: Both Ang-II and Ang-(1–7) expression are significantly increased in patients with critical CAD. However, increased Ang-II/Ang-(1–7) ratios may lead to Ang-II over-activation and aggravate atherosclerosis progression. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - July 17, 2016 Category: Biomedical Science Authors: Li, W., Li, J., Hao, P., Chen, W., Meng, X., Li, H., Zhang, Y., Zhang, C., Yang, J. Tags: Original Article Source Type: research

Chronic p38 mitogen-activated protein kinase inhibition improves vascular function and remodeling in angiotensin II-dependent hypertension
Conclusions: Our findings indicated there is an important role for p38-MAPK in regulating blood pressure and vascular injury, and highlighted its potential as a pharmaceutical target. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - July 11, 2016 Category: Biomedical Science Authors: Potthoff, S., Stamer, S., Grave, K., Königshausen, E., Sivritas, S., Thieme, M., Mori, Y., Woznowski, M., Rump, L., Stegbauer, J. Tags: Original Article Source Type: research

Renin-angiotensin system blockade for the risk of cancer and death
Conclusions: The significant benefits of renin–angiotensin system blockade observed in case–control studies and cohort studies might diminish in randomised controlled trials. Clinical design, site of cancer and duration of follow-up may affect the clinical outcomes. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - July 7, 2016 Category: Biomedical Science Authors: Shen, J., Huang, Y.-M., Wang, M., Hong, X.-Z., Song, X.-N., Zou, X., Pan, Y.-H., Ling, W., Zhu, M.-H., Zhang, X.-X., Sui, Y., Zhao, H.-L. Tags: Original Article Source Type: research

Protection against death and renal failure by renin-angiotensin system blockers in patients with diabetes and kidney disease
Conclusions: In patients with diabetes and kidney disease, ACEis and ARBs are consistently protective for the development of ESRD. Use of ACEis alone additionally reduces deaths and increases the risk for cough. Use of ARBs alone increases the risk for hyperkalemia without additional benefit of death protection. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - July 2, 2016 Category: Biomedical Science Authors: Shen, J., Huang, Y.-M., Song, X.-N., Hong, X.-Z., Wang, M., Ling, W., Zhang, X.-X., Zhao, H.-L. Tags: Original Article Source Type: research

Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 A1166C and AGTR2 G1675A gene polymorphisms
Conclusions: The relation between sodium reabsorption in the distal tubule and the development of arterial stiffness depends on the AGTR2 G1675A polymorphism in blood pressure independent fashion. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 22, 2016 Category: Biomedical Science Authors: Cwynar, M., Gasowski, J., Głuszewska, A., Krolczyk, J., Barton, H., Słowik, A., Grodzicki, T. Tags: Original Article Source Type: research

Association of serum levels of AngII, KLK1, and ACE/KLK1 polymorphisms with acute myocardial infarction induced by coronary artery stenosis
Conclusions: (1) Increasing the serum levels of AngII increased the risk of AMI. (2) The risk of AMI increased significantly when the serum levels of AngII and KLK1 simultaneously increased. (3) Individuals with the combined genotypes of ACE DD and KLK1 GG showed significantly increased risk of AMI compared with those with the combined genotypes of ACE II and KLK1 AA. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 20, 2016 Category: Biomedical Science Authors: Dai, S.-h., Li, J.-f., Feng, J.-b., Li, R.-j., Li, C.-b., Li, Z., Zhang, Y., Li, D.-q. Tags: Original Article Source Type: research