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Lack of RAAS inhibition by high-salt intake is associated with arterial stiffness in hypertensive patients
Conclusions: We showed a) an inverse salt-RAAS relation, b) an association between HS plus high RAAS with increased PWV that could identify a higher-risk hypertensive condition. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Kotliar, C., Kempny, P., Gonzalez, S., Castellaro, C., Forcada, P., Obregon, S., Cavanagh, E., Chiabaut Svane, J., Casarini, M. J., Rojas, M., Inserra, F. Tags: Original Articles Source Type: research

The effect of renin-angiotensin system blockade on renal protection in chronic kidney disease patients with hyperkalemia
Conclusions: This study demonstrated that the maintenance of RAS blockade is beneficial for the preservation of renal function and relatively tolerable in patients with CKD and hyperkalemia occurring during treatment with RAS blockade. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Lee, J.-H., Kwon, Y. E., Park, J. T., Lee, M. J., Oh, H. J., Han, S. H., Kang, S.-W., Choi, K. H., Yoo, T.-H. Tags: Original Articles Source Type: research

Elevated circulating alpha-klotho by angiotensin II receptor blocker losartan is associated with reduction of albuminuria in type 2 diabetic patients
Conclusions: The angiotensin receptor blocker losartan increases circulating α-klotho in T2DM with albuminuria. The clinical significance of this rise in α-klotho associated with losartan intervention deserves further investigation. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Lim, S. C., Liu, J.-J., Subramaniam, T., Sum, C. F. Tags: Original Articles Source Type: research

Cardiovascular effects of angiotensin A: A novel peptide of the renin-angiotensin system
Conclusions: These data suggest that the existence of alternative peptides of the renin–angiotensin system (RAS) might contribute to the limited effects of angiotensin receptor blockers (ARBs) in certain pathophysiological circumstances. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Coutinho, D. C., Foureaux, G., Rodrigues, K. D., Salles, R. L., Moraes, P. L., Murca, T. M., De Maria, M. L., Gomes, E. R., Santos, R. A., Guatimosim, S., Ferreira, A. J. Tags: Original Articles Source Type: research

Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages
Conclusion: IRAP is more highly expressed in pro-inflammatory M1-activated macrophages and its presence at the cell surface is modulated upon exposure to IFN-, LPS or exogenous particles. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Nikolaou, A., Stijlemans, B., Laoui, D., Schouppe, E., Tran, H. T., Tourwe, D., Chai, S. Y., Vanderheyden, P. M., Van Ginderachter, J. A. Tags: Original Articles Source Type: research

Paradoxical expressions of natriuretic peptide receptor-C and neutral endopeptidase account for C-type natriuretic peptide decline during the progression of experimental obstructive nephropathy
Conclusions: A high level of CNP may contribute to the elevated expression of NPR-B in the early phase of UUO. More interestingly, paradoxical expressions of NPR-C and NEP may account for the decline of CNP in the obstructed kidneys. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Hu, P., Zhao, X. Q., Wang, J., Kong, H. B., Hu, B., Lu, L., Qin, Y. H. Tags: Original Articles Source Type: research

Do Angiotensin Type 2 Receptors Modulate Haemodynamic Effects of Type 1 Receptors in Conscious Newborn Lambs?
Conclusions: AT2Rs do not counterbalance the pressor and renal vasoconstrictor effects elicited by activation of AT1Rs in the immediate newborn period. During this time, AT1Rs appear to predominate in eliciting the haemodynamic effects of angiotensin II (ANG II), whereas the role of the upregulated AT2Rs remains elusive. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Vinturache, A. E., Smith, F. G. Tags: Original Articles Source Type: research

Proliferative changes of renal arteriolar walls induced by administration of angiotensin II receptor blocker are frequent in juvenile rats
Conclusion: This study indicates that ARB administration induces unusual proliferative changes and a marked renin-producing cell increase in afferent arterioles more frequently in juveniles than adult rats. It is suggested that the treatment of ARB in juveniles might have a higher risk of changes in renal afferent arterioles. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Nagai, Y., Nakanishi, K., Akimoto, T., Yamanaka, N. Tags: Original Articles Source Type: research

Brazilian embauba (Cecropia pachystachya) extract reduces renal lesions in 5/6 nephrectomized rats
Conclusions: The treatment with CP extract reduced the SBP and functional and structural renal changes in 5/6 NE rats. These effects were associated with decreased AII expression, ACE activity and inflammation in the renal cortex. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: do C Maquiaveli, C., da Silva, E. R., Francescato, H. D., Costa, R. S., Silva, C. G., Casarini, D. E., Ronchi, F. A., Coimbra, T. M. Tags: Original Articles Source Type: research

Angiotensin modulates human mammary epithelial cell motility
Conclusions: The results indicate that angiotensin II modulates cell behaviour via AT1-R and stimulates secretion of MMP-2 by human mammary epithelial cells. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Piastowska-Ciesielska, A. W., Domiłska, K., Nowakowska, M., Gajewska, M., Gajos-Michniewicz, A., Ochędalski, T. Tags: Original Articles Source Type: research

Dual therapy of vildagliptin and telmisartan on diabetic nephropathy in experimentally induced type 2 diabetes mellitus rats
Conclusions: The addition of telmisartan to vildagliptin demonstrated the best control over blood pressure, glycemia and diabetic nephropathy markers, renal structural changes and improvement of renal function as opposed to monotherapy with either drug, possibly because of the dual inhibitory effect on the renin–angiotensin system. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Sharma, A. K., Kanawat, D. S., Mishra, A., Dhakad, P. K., Sharma, P., Srivastava, V., Joshi, S., Joshi, M., Raikwar, S. K., Kurmi, M. K., Srinivasan, B. P. Tags: Original Articles Source Type: research

Constitutive activation of the renin-angiotensin system reduces visceral fat and improves glucose tolerance in mice
Conclusion: Chronic RAS activation is not sufficient to cause insulin resistance in mice. Moreover, adaptation to constitutive RAS activation in mice results in a better glucose tolerance. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Favre, G. A., Lebrun, P., Lopez, P., Butori, C., Hofman, P., Esnault, V. L., Van Obberghen, E. Tags: Original Articles Source Type: research

Protective effects of aliskiren and valsartan in mice with diabetic nephropathy
Conclusion: Our study indicates that aliskiren and/or valsartan protects against diabetic kidney disease through multiple mechanisms, including decreasing podocyte injury, activation of profibrotic growth factors and proinflammatory cytokines, ER stress and accumulation of lipids. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Wang, W., Qiu, L., Howard, A., Solis, N., Li, C., Wang, X., Kopp, J. B., Levi, M. Tags: Original Articles Source Type: research

Influence of atorvastatin on angiotensin I metabolism in resting and TNF-{alpha} -activated rat vascular smooth muscle cells
Conclusions: Enhancement by atorvastatin of the ACE2/Ang-(1–7) axis in VSMCs could represent a new and beneficial mechanism on cardiovascular action of this widely used drug. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Suski, M., Gębska, A., Olszanecki, R., Stachowicz, A., Uracz, D., Madej, J., Korbut, R. Tags: Original Articles Source Type: research

The role of oxidative stress in renal injury induced in rats by losartan exposure during lactation
Conclusion: Oxidative stress contributes at least in part to the renal injury observed in pups exposed to losartan during lactation. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Marin, E. C. S., Francescato, H. D. C., Costa, R. S., da Silva, C. G. A., Coimbra, T. M. Tags: Original Articles Source Type: research