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Cerebroprotective effects of RAS inhibitors: Beyond their cardio-renal actions
Work on the brain renin–angiotensin system has been explored by various researchers and has led to elucidation of its basic physiologies and behavior, including its role in reabsorption and uptake of body fluid, blood pressure maintenance with angiotensin II being its prominent effector. Currently, this system has been implicated for its newly established effects, which are far beyond its cardio-renal effects accounting for maintenance of cerebral blood flow and cerebroprotection, seizure, in the etiology of Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and bipolar disorder. In this review...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 7, 2015 Category: Biomedical Science Authors: Kalra, J., Prakash, A., Kumar, P., Majeed, A. B. A. Tags: Invited Review Source Type: research

Lack of association between ACE insertion/deletion polymorphism and lung cancer: A meta-analysis
Conclusion: We concluded that the ACE gene I/D polymorphism was not associated with lung cancer. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Cheng, Z., Ma, R., Tan, W., Zhang, L., Tan, Q. Tags: Original Articles Source Type: research

AGT M235T variant is not associated with risk of cancer
Conclusion The present meta-analysis demonstrated that AGT M235T variant was not associated with risk of all cancer or various cancers. Further well-designed studies with large sample size should be conducted to confirm or refute the non-significant association. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Lin, J., Chen, J., Liu, C. Tags: Original Articles Source Type: research

Angiotensin-converting enzyme insertion/deletion gene polymorphisms is associated with risk of glioma in a Chinese population
Conclusion: Our study suggested that the ACE DD genotype was associated with a higher glioma risk in this Chinese population. To the best of our knowledge, this is the first report describing the potential association between ACE I/D polymorphism and glioma. Additional studies are needed to confirm this finding. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Lian, M., Jiang, H., Wang, H., Guo, S. Tags: Original Articles Source Type: research

The insertion/deletion polymorphism in the angiotensin-converting enzyme and susceptibility to schizophrenia or Parkinson's disease: A meta-analysis
Conclusions: This meta-analysis found no association between the ACE I/D polymorphism and schizophrenia or PD. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Song, G. G., Lee, Y. H. Tags: Original Articles Source Type: research

The angiotensin-converting enzyme (ACE) I/D polymorphism in Parkinson's disease
Conclusion: The meta-analysis suggests that there is no evidence for the association between ACE gene I/D polymorphism and PD risk. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Su, G., Dou, H., Zhao, L., Wang, H., Liu, G., Huang, B., Peng, B. Tags: Original Articles Source Type: research

Angiotensin converting enzyme intron 16 insertion/deletion genotype is associated with plasma C-reactive protein concentration in uteroplacental dysfunction
Conclusions: The ACE I/D genotype is significantly associated with CRP elevations during pregnancies complicated by disturbed UPC. Whether this effect on CRP is involved in pathogenesis of preeclampsia has to be elucidated. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Haupl, T., Zimmermann, M., Kalus, U., Yurek, S., Koscielny, J., Hoppe, B. Tags: Original Articles Source Type: research

Association between angiotensin-converting enzyme I/D polymorphism and sepsis: A meta-analysis
Conclusions: Our meta-analysis confirmed that the angiotensin-converting enzyme I/D polymorphism was associated with sepsis risk. However, the angiotensin-converting enzyme I/D polymorphism was not associated with sepsis mortality. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Hou, X., Zhang, P., Nie, W., Tang, S., Wang, J., Zhang, Q., Wan, Z., Zhang, B., Song, B. Tags: Original Articles Source Type: research

Simple renal cysts and hypertension are associated with angiotensinogen (AGT) gene variant in Shiraz population (Iran)
Conclusions: Our findings show a relationship between the AGT-TT genotype and hypertension in patients with both hypertension and simple renal cysts. This finding suggests an additive role for the AGT gene of the renin-angiotensin system in the process of hypertension and simple renal cysts formation. Future studies are needed to elucidate the mechanisms through which this association is mediated. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Tabei, S., Nariman, A., Daliri, K., Roozbeh, J., Khezri, A., Goodarzi, H., Lotfi, M., Sefidbakht, S., Entezam, M. Tags: Original Articles Source Type: research

A polymorphism (-455G>A) in the {beta}-fibrinogen gene is associated with an increased risk of cerebral infarction in the Chinese population: A meta-analysis
Conclusion: The results of our meta-analysis indicate that the -455G>A polymorphism in the β-fibrinogen gene is a susceptibility marker of ischemic cerebral infarction in the Chinese population. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Cheng, S.-Y., Zhao, Y.-D., Zeng, J.-W., Chen, X.-Y., Wang, R.-D. Tags: Original Articles Source Type: research

Haplotype analyses of CYP17A1 genetic polymorphisms and coronary artery disease in a Uygur population
Conclusion: Polymorphisms rs4919686, rs4919687 and rs1004467 were found to be associated with CAD in this Uygur population. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Dai, C.-F., Xie, X., Ma, Y.-T., Yang, Y.-N., Li, X.-M., Fu, Z.-Y., Liu, F., Chen, B.-D., Gai, M.-T. Tags: Original Articles Source Type: research

The CYP11B2 -344C/T variant is associated with ischemic stroke risk: An updated meta-analysis
Conclusion: The present meta-analysis supported the positive association of the CYP11B2 –344C/T variant with ischemic stroke. Further large-scale studies considering gene–gene/gene–environment interactions should be conducted to investigate the association. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Yu, Y. Tags: Original Articles Source Type: research

ACE genotype, phenotype and all-cause mortality in different cohorts of patients with type 1 diabetes
Conclusion: In unselected patients with type 1 diabetes, carrying the ACE D-allele and high spontaneous serum ACE activity were associated with 12-year excess mortality. These findings could not be reproduced in two other cohorts with persistent normoalbuminuria or diabetic nephropathy. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Faerch, L. H., Sejling, A.-S., Lajer, M., Tarnow, L., Thorsteinsson, B., Pedersen-Bjergaard, U. Tags: Original Articles Source Type: research

Association between eprosartan-based hypertension therapy and improvement in cognitive function score: long-term follow-up from the OSCAR observational study
Conclusions: In this cohort of patients, use of eprosartan-based treatment for one year was associated with sustained reduction in blood pressure and stabilization or improvement of MMSE scores. These data are supportive of a role for blood pressure control in the prevention or delay of cognitive decline. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Hanon, O., Lee, Y.-S., Pathak, A., on behalf of the OSCAR Publication Group Tags: Original Articles Source Type: research

A pilot study of the effects of eplerenone add-on therapy in patients taking renin-angiotensin system blockers
Conclusions: Ep add-on therapy in patients taking renin–angiotensin system blockers is expected to reduce BP, even in patients with low PAC. In contrast, the anti-proteinuric action of Ep is dependent on baseline plasma aldosterone levels. TTKG is not appropriate for evaluating the efficacy of Ep. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Kawada, N., Isaka, Y., Kitamura, H., Rakugi, H., Moriyama, T. Tags: Original Articles Source Type: research