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Mineralocorticoid receptor blockade inhibits accelerated atherosclerosis induced by a low sodium diet in apolipoprotein E-deficient mice
Conclusion: In E0 mice, Epl inhibited LSD-accelerated atherosclerosis, despite the elevation of renin and aldosterone levels. It is therefore suggested that the atherogenic action of LSD could be mediated, at least in part, by activation of the mineralocorticoid receptor. In addition, eplerenone may have direct anti-inflammatory actions. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Raz-Pasteur, A., Gamliel-Lazarovich, A., Gantman, A., Coleman, R., Keidar, S. Tags: Articles Source Type: research

Effects of angiotensin II type 1 receptor blocker on bones in mice with type 1 diabetes induced by streptozotocin
Conclusion: Local bone RAS functionally played a role in the development of type 1 diabetic osteoporosis, and losartan had no bone-sparing function in diabetes mice because of enhance skeletal RAS activity. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Zhang, Y., Diao, T.-Y., Gu, S.-S., Wu, S.-Y., Gebru, Y. A., Chen, X., Wang, J.-Y., Ran, S., Wong, M.-S. Tags: Articles Source Type: research

Expressional profile of cardiac uncoupling protein-2 following myocardial ischemia reperfusion in losartan- and ramiprilat-treated rats
Conclusion: These findings suggest that losartan and ramiprilat can suppress UCP2 expression following myocardial IR, and by this mechanism may protect the myocardium against IR injury. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Safari, F., Bayat, G., Shekarforoush, S., Hekmatimoghaddam, S., Anvari, Z., Moghadam, M. F., Hajizadeh, S. Tags: Articles Source Type: research

Resistant hypertension and renal denervation: Who's kidding whom?
(Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Sever, P. Tags: Commentary Source Type: research

Effects of antihypertensive therapy on glucose, insulin metabolism, left ventricular diastolic dysfunction and renin system in overweight and obese hypertensives
Conclusions: Optimal target BP was achieved in the group as a whole and in both obese patient groups, while benefits to cardiac structure were of a smaller magnitude. In high-risk, overweight/obese patients with hypertension, traditional therapy provides significantly greater BP- versus aliskiren-lowering throughout the 24-hour dosing interval. Therefore in obese, hypertensive individuals, adequate and similar blood pressure control was achieved with aliskiren; however, the aliskiren group and not the control group was associated with a more favorable GIM profile and led to a significant regression of LVM; overall aliskire...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 9, 2014 Category: Biomedical Science Authors: De Rosa, M. L., Musella, F., Ilardi, F., D'Amore, C., Luciano, R., Maresca, F. Tags: Articles Source Type: research

The M235T polymorphism in the angiotensinogen gene and heart failure: a meta-analysis
Conclusions: The current meta-analysis suggests that M235T polymorphism might be associated with increased risk of heart failure in Caucasians. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 9, 2014 Category: Biomedical Science Authors: Chen, S., Zhang, L., Wang, H.-W., Wang, X.-Y., Li, X.-Q., Zhang, L.-L. Tags: Articles Source Type: research

Targeting reduction of proteinuria in glomerulonephritis: Maximizing the antifibrotic effect of valsartan by protecting podocytes
Although angiotensin (Ang) II blockade has become a standard antifibrotic therapy in kidney disease, the therapeutic efficacy of Ang II blockade is yet to be optimized. Considering the prognostic impact of proteinuria reduction, we hypothesized that titration of Ang II blockade for optimal anti-proteinuric effect would improve renoprotection. One day after induction of Thy 1.1 glomeruonephritis, rats were treated with increasing doses of the Ang II receptor blocker valsartan in drinking water. Six days after disease induction, the therapeutic effect on proteinuria, podocyte injury and glomerular fibrosis was evaluated. Inc...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 9, 2014 Category: Biomedical Science Authors: Gu, C., Zhou, G., Noble, N. A., Border, W. A., Cheung, A. K., Huang, Y. Tags: Articles Source Type: research

MDR-1 C3435T polymorphism may affect blood pressure in resistant hypertensive patients independently of its effects on aldosterone release
Aldosterone increases plasma volume and may be involved with resistant hypertension. P-glycoprotein is a transporter involved in the distribution and disposition of aldosterone, and is encoded by the MDR-1 gene. MDR-1 has functional polymorphisms that may affect P-glycoprotein expression. We hypothesized that the C3435T polymorphism in MDR-1 could be associated with resistant hypertension and with changes in hypertension-related parameters. We studied 105 healthy volunteers, 137 hypertensive patients responsive to treatment, and 83 resistant hypertensive patients. While we found no association of C3435T genotypes with resi...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 9, 2014 Category: Biomedical Science Authors: Lacchini, R., Figueiredo, V. N., Demacq, C., Coeli-Lacchini, F. B., Martins, L. C., Yugar-Toledo, J., Coca, A., Tanus-Santos, J. E., Moreno, H. Tags: Articles Source Type: research

Imidapril provides a protective effect on pulmonary hypertension induced by low ambient temperature in broiler chickens
Conclusion: Imidapril provides a protective effect on pulmonary hypertension induced by low ambient temperature in broiler chickens. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 9, 2014 Category: Biomedical Science Authors: Hao, X.-Q., Zhang, S.-Y., Li, M., Yang, Z., Niu, M.-F., Sun, T.-W., Yang, D.-L., Kong, T., Li, J. Tags: Articles Source Type: research

Synergistic effects of angiotensinogen -217 G->A and T704C (M235T) variants on the risk of severe preeclampsia
Conclusions: The present study demonstrates that both variants of AGT –217 G->A and T704C might work in synergism to influence the risk of severe preeclampsia, which needs to be confirmed in studies with larger sample size. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 9, 2014 Category: Biomedical Science Authors: Shahvaisizadeh, F., Movafagh, A., Omrani, M. D., Vaisi-Raygani, A., Rahimi, Z., Rahimi, Z. Tags: Articles Source Type: research

The -344C/T polymorphism in the CYP11B2 gene is associated with essential hypertension in the Chinese
Conclusions: Our study suggested that the –344T/C polymorphism in the CYP11B2 gene was significantly associated with hypertension in the Chinese population, especially in the Han Chinese. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 9, 2014 Category: Biomedical Science Authors: Li, W., Liu, C. Tags: Articles Source Type: research

Developmental expression patterns for angiotensin receptors in mouse skin and brain
Two G-protein-coupled receptors, angiotensin type 1 receptor (AT1R) and type 2 receptor (AT2R), mediate the majority of angiotensin II (Ang II) effects. It has long been believed that the AT2R is reduced to extremely low levels in adulthood but is abundantly expressed in the fetus. However, recent data from rats and mice do not support this notion. Employing Western blot analysis, we found a gradual increase in AT2R protein expression from fetal life to adulthood in brain, heart, lung, liver, and kidney. The reason for the discrepancy between our observations and the conventional concept is unknown. Evidence supporting a r...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 9, 2014 Category: Biomedical Science Authors: Yu, L., Shao, C., Gao, L. Tags: Articles Source Type: research

Angiotensin II type I receptor A1166C polymorphism increases the risk of pregnancy hypertensive disorders: Evidence from a meta-analysis
Pregnancy hypertensive disorders (PHDs) are considered to be a multifactorial and multisystemic disorder with a genetic predisposition. Alterations in the renin–angiotensin system are considered to play a significant role in the pathogenesis of the PHDs. However, results from published studies on the association between the angiotensin II type-1 receptor (AT1R) A1166C (rs5186) gene polymorphism and the risk of PHDs are conflicting. The aim of this meta-analysis was to investigate whether an association exists between AT1R A1166C gene polymorphism and PHDs in epidemiologic studies. We searched the PubMed, China Nation...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 9, 2014 Category: Biomedical Science Authors: Zhang, L., Yang, H., Qin, H., Zhang, K. Tags: Articles Source Type: research

Genetic variants of ACE (Insertion/Deletion) and AGT (M268T) genes in patients with diabetes and nephropathy
Conclusion: Significant differences were observed in the DD genotype and D allele of the ACE gene and the TT genotype and T allele of AGT genes between diabetic patients with and without nephropathy. The study may conclude that the D allele polymorphism in the ACE gene and the T allele polymorphism in AGT gene may be considered as genetic risk factors for the development of nephropathy in diabetes. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 9, 2014 Category: Biomedical Science Authors: Shaikh, R., Shahid, S. M., Mansoor, Q., Ismail, M., Azhar, A. Tags: Articles Source Type: research

The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity
Conclusions: This study demonstrated the different responses of renin and aldosterone in SS and SR subjects based on dietary sodium intake whether or not they had hypertension. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 9, 2014 Category: Biomedical Science Authors: Shin, S. J., Lim, C., Oh, S. W., Rhee, M.-Y. Tags: Articles Source Type: research