Effects of angiotensin II type 1 receptor blocker on bones in mice with type 1 diabetes induced by streptozotocin

Conclusion:
Local bone RAS functionally played a role in the development of type 1 diabetic osteoporosis, and losartan had no bone-sparing function in diabetes mice because of enhance skeletal RAS activity.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Zhang, Y., Diao, T.-Y., Gu, S.-S., Wu, S.-Y., Gebru, Y. A., Chen, X., Wang, J.-Y., Ran, S., Wong, M.-S. Tags: Articles Source Type: research