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Hypokalemia correlated with arterial stiffness but not microvascular endothelial function in patients with primary aldosteronism
Conclusions: PA patients had higher arterial stiffness but comparable microvascular endothelial function to EH patients. Hypokalemia correlated with arterial stiffness but not microvascular endothelial function in PA patients. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Chang, Y.-Y., Chen, A., Chen, Y.-H., Hung, C.-S., Wu, V.-C., Wu, X.-M., Lin, Y.-H., Ho, Y.-L., Wu, K.-D., the TAIPAI Study Group Tags: Original Articles Source Type: research

Aliskiren improves vascular smooth muscle function in the skin microcirculation of type 2 diabetic patients with normal renal function
Conclusions: Aliskiren improves blood pressure and vascular smooth muscle function in the skin microcirculation of T2DM patients. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Dushay, J. R., Tecilazich, F., Kafanas, A., Magargee, M. L., Auster, M. E., Gnardellis, C., Dinh, T., Veves, A. Tags: Original Articles Source Type: research

The effect of blood collection procedure on plasma renin activity (PRA) and concentrations of direct renin (DRC) and aldosterone
Conclusion: The measurements of DRC, and to a lesser extent PRA, were similar regardless of temperature condition during the 20–30 minutes necessary for blood sample processing. Aldosterone concentrations in plasma vs serum samples appeared to be markedly higher. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Glinicki, P., Jeske, W., Gietka-Czernel, M., Bednarek-Papierska, L., Kruszyłska, A., Słowiłska-Srzednicka, J., Zgliczyłski, W. Tags: Original Articles Source Type: research

Haemostatic and inflammatory alterations in familial hypercholesterolaemia, and the impact of angiotensin II infusion
Conclusions: FH exhibits an increased thrombin generation potential, an intact fibrinolysis, and has no convincing signs of inflammation. Angiotensin has proinflammatory effects, and might have minor profibrinolytic and procoagulatory effects. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Ekholm, M., Kahan, T., Jorneskog, G., Brinck, J., Wallen, N. H. Tags: Original Articles Source Type: research

In vitro comparison of bradykinin degradation by aliskiren, a renin inhibitor, and an inhibitor of angiotensin-converting enzyme
Conclusion: Aliskiren has no effect upon the rate of bradykinin degradation in plasma and a minimal effect employing vascular endothelial cells. The latter suggests inhibition of a non-renin enzyme that is a minor contributor to bradykinin degradation. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Joseph, K., Tholanikunnel, T. E., Kaplan, A. P. Tags: Original Articles Source Type: research

Vascular angiotensin II type 2 receptor attenuates atherosclerosis via a kinin/NO-dependent mechanism
Conclusions: Vascular AT2 stimulation exerts anti-atherogenic actions in an endothelial kinin/NO-dependent manner, and its anti-oxidative effect is likely to be exerted by inhibiting the accumulation of superoxide-producing mononuclear leukocytes. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Takata, H., Yamada, H., Kawahito, H., Kishida, S., Irie, D., Kato, T., Wakana, N., Miyagawa, S., Fukui, K., Matsubara, H. Tags: Original Articles Source Type: research

Inhibition of local aldosterone by eplerenone reduces renal structural damage in a novel model of chronic cyclosporine A nephrotoxicity
Conclusion: Our results suggest local renal aldosterone is an important mediator of renal injury induced by CsA. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Sun, Q.-L., Li, M., Rui, H.-L., Chen, Y.-P. Tags: Original Articles Source Type: research

ACE2 activity was increased in atherosclerotic plaque by losartan: Possible relation to anti-atherosclerosis
Conclusions: The results showed that ACE2 activity was regulated in atherosclerotic plaque by losartan, which may play an important role in treatment of atherosclerosis. The mechanism involves Ang II–AT1R-mediated mitogen-activated protein kinases, MAPKs (MAPKs) signaling pathway. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Zhang, Y. H., Hao, Q. Q., Wang, X. Y., Chen, X., Wang, N., Zhu, L., Li, S. Y., Yu, Q. t., Dong, B. Tags: Original Articles Source Type: research

Aliskiren inhibits prorenin-induced human aortic smooth muscle cell migration
Conclusions: Taken together, we provide the first evidence of the inhibitory action of aliskiren on SMC migration induced by prorenin. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Ferri, N., Panariti, F., Ricci, C., Maiocchi, G., Corsini, A. Tags: Original Articles Source Type: research

The components of the angiotensin-(1-7) system are differentially expressed during follicular wave in cattle
Conclusions: mRNA for Mas receptor, ACE2, and PEP are differentially expressed in granulosa cells throughout follicular development and the Mas receptor can be involved with the establishment of follicular dominance. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Barreta, M. H., Gasperin, B. G., Ferreira, R., Rovani, M., Pereira, G. R., Bohrer, R. C., de Oliveira, J. F., Goncalves, P. B. D. Tags: Original Articles Source Type: research

Hydronephrosis alters cardiac ACE2 and Mas receptor expression in mice
Conclusions: Hydronephrosis increased cardiac ACE and suppressed ACE2 and Mas receptor levels. AT1 blockade caused sustained activation of cardiac ACE2 and Mas receptor, but ACE inhibitor had the limitation of such activation of Mas receptor in hydronephrotic animals. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Zhang, Y., Ma, L., Wu, J., Chen, T. Tags: Original Articles Source Type: research

Influence of tacrolimus on podocyte injury inducted by angiotensin II
Conclusion: FK506 can directly act on the podocytes to inhibit Ang II-induced damage on podocyte structures and reduce the apoptosis rate of podocytes, which may be related to stabilizing TRPC6 expression and distribution in podocytes by FK506, thus maintaining the structure and function integrity of the slit diaphragm and playing a role in protecting podocytes and antiproteinuria. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Shengyou, Y., Li, Y., Zhihong, H., Yuanyuan, M. Tags: Original Articles Source Type: research

Ang (1-7) is a modulator of the vasoconstrictor actions of Ang I and Ang II
Conclusion: Ang (1–7) showed a modulatory role, suggesting Ang I did as well after treatment with an ACE inhibitor but not with an AT1 receptor antagonist. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Flores-Monroy, J., Valencia-Hernandez, I., Martinez-Aguilar, L. Tags: Original Articles Source Type: research

Activation of renin-angiotensin-aldosterone system (RAAS) in the lung of smoking-induced pulmonary arterial hypertension (PAH) rats
Conclusion: Chronic cigarette exposure may result in PAH and affect the protein expression of ACE2 and ACE in lung tissue, suggesting that ACE2 and ACE play an important role in the pathogenesis of smoking-induced PAH. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Yuan, Y.-M., Luo, L., Guo, Z., Yang, M., Ye, R.-S., Luo, C. Tags: Original Articles Source Type: research

ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation
Conclusion: The results show following an abrupt decline in podocyte number, the initiation of ACE-inhibition but not hydralazine, was accompanied by higher podocyte number in the absence of proliferation. This was accompanied by a higher number of parietal epithelial cells that co-express podocyte proteins. Increasing podocyte number appears to be accompanied by reduced glomerulosclerosis. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Zhang, J., Yanez, D., Floege, A., Lichtnekert, J., Krofft, R. D., Liu, Z.-H., Pippin, J. W., Shankland, S. J. Tags: Original Articles Source Type: research