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Dipeptidyl peptidase-4 inhibitor sitagliptin improves pancreatic {beta}-cell function in hypertensive diabetic patients treated with angiotensin receptor blockers
Conclusion: Treatment with the DPP-4 inhibitor sitagliptin might exert beneficial effects on pancreatic β-cell function in ARB-treated T2DM patients and its efficacy might be more pronounced in hypoglycemic drug naïve patients. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Fukui, K., Kawahito, H., Wakana, N., Kikai, M., Terada, K., Yamamoto, K., Irie, D., Kato, T., Miyagawa, S., Yamada, H. Tags: Original Articles Source Type: research

Dexmedetomidine protects spatial learning and memory ability in rats
Conclusion: Combine use of dexmedetomidine during exposure to isoflurane in utero during middle-pregnancy can attenuate the impairment of spatial learning and memory abilities for the rats in adulthood. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Su, Z., Xu, S., Chen, T., Chen, J. Tags: Original Articles Source Type: research

Correlation of ACE gene deletion/insertion polymorphism and risk of pregnancy-induced hypertension: a meta-analysis based on 10,236 subjects
Conclusion: The ACE gene insertion/deletion polymorphism is associated with the risk of pregnancy-induced hypertension. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Miao, H.-W., Gong, H. Tags: Original Articles Source Type: research

Correlation between renin-angiotensin system gene polymorphisms and essential hypertension in the Chinese Yi ethnic group
Conclusions: The RAS-related ACE G2350A polymorphism is associated with the pathogenesis of EH in the Chinese Yi ethnic group. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Yang, Y.-L., Mo, Y.-P., He, Y.-S., Yang, F., Xu, Y., Li, C.-C., Wang, J., Reng, H.-M., Long, L. Tags: Original Articles Source Type: research

Comparison of benazepril and losartan on endothelial function and vascular stiffness in patients with Type 2 diabetes mellitus and hypertension: A randomized controlled trial
Conclusions: Hypertensive diabetic patients using benazepril had a greater reduction in C-reactive protein, and a slight improvement in FMD, than those taking losartan. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Gismondi, R. A., Oigman, W., Bedirian, R., Pozzobon, C. R., Ladeira, M. C. B., Neves, M. F. Tags: Original Articles Source Type: research

Comment on: IgA nephropathy with early kidney disease is associated with increased arterial stiffness and renin-angiotensin system activity
We read with great interest the article by Abdi-Ali et al. entitled "IgA nephropathy with early kidney disease is associated with increased arterial stiffness and renin–angiotensin system activity" in the recent issue of Journal of the Renin–Angiotensin–Aldosterone System. In a study on 10 normotensive IgA nephropathy (IgAN) subjects with early kidney disease and 10 gender- and blood pressure-matched healthy controls, blood pressure and arterial stiffness, expressed as pulse wave velocity and aortic augmentation index, at baseline and in response to 60 min of angiotensin II (AngII) infusion were measured....
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Mubarak, M., Nasri, H., Rafieian-Kopaei, M. Tags: Comment Source Type: research

Combination therapy with aliskiren versus ramipril or losartan added to conventional therapy in patients with type 2 diabetes mellitus, uncontrolled hypertension and microalbuminuria
Conclusions: The addition of aliskiren to optimal conventional therapy provided a higher reduction of blood pressure and urinary albumin excretion when compared with the addition of losartan or ramipril. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Imbalzano, E., Scarpelli, M., Mandraffino, G., Creazzo, M., Lizio, G., Trapani, G., Dattilo, G., Dalbeni, A., Tomasello, C., Sardo, M. A., Saitta, A. Tags: Original Articles Source Type: research

Characterization of the renal renin-angiotensin system in transgenic mice that express rat tonin
Conclusions: We suggest that the environment of tonin abundance may increase N-domain ACE activity liberated by a secretase able to cleave somatic ACE. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Ribeiro, A. A., Palomino, Z., Lima, M. P., Souza, L. E., Ferreira, D. S., Pesquero, J. B., Irigoyen, M. C., Pesquero, J. L., Casarini, D. E. Tags: Original Articles Source Type: research

Bone marrow angiotensin AT2 receptor deficiency aggravates atherosclerosis development by eliminating macrophage liver X receptor-mediated anti-atherogenic actions
Conclusions: Our findings demonstrate that BM-AT2 deficiency aggravates atherosclerosis, at least in part, by eliminating the anti-atherogenic properties of macrophages elicited by LXRβ activation. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Kato, T., Kawahito, H., Kishida, S., Irie, D., Wakana, N., Kikai, M., Takata, H., Ogata, T., Ueyama, T., Matoba, S., Yamada, H. Tags: Original Articles Source Type: research

Blood pressure reduction and control with fixed-dose combination perindopril/amlodipine: A Pan-Hellenic prospective observational study
Conclusions: Fixed-dose perindopril/amlodipine safely and effectively reduced high BP in real-life practice, achieving BP control in most patients. About half of Greek hypertensive patients have high/very high added cardiovascular risk. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Manolis, A., Grammatikou, V., Kallistratos, M., Zarifis, J., Tsioufis, K. Tags: Original Articles Source Type: research

Beneficial effect of candesartan and lisinopril against haloperidol-induced tardive dyskinesia in rat
Conclusions: The present study supports the therapeutic use of candesartan and lisinopril in the treatment of typical antipsychotic-induced orofacial dyskinesia and possible antioxidant and neuro-inflammatory mechanisms. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Thakur, K. S., Prakash, A., Bisht, R., Bansal, P. K. Tags: Original Articles Source Type: research

Association of the insertion allele of the common ACE gene polymorphism with type 2 diabetes mellitus among Kuwaiti cardiovascular disease patients
Conclusion: The ACE I allele is found to be associated with T2DM; however, no association was observed with CVD. The inconsistency between studies is suggested to be attributed to genetic diversity due to the existence of sub-populations found in Asian populations. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Al-Serri, A., Ismael, F. G., Al-Bustan, S. A., Al-Rashdan, I. Tags: Original Articles Source Type: research

Association of AT1R polymorphism with hypertension risk: An update meta-analysis based on 28,952 subjects
Conclusions: This meta-analysis suggests that A1166C polymorphism in the AT1R gene is associated with the risk of hypertension in Asian and Caucasian populations. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Liu, D.-X., Zhang, Y.-Q., Hu, B., Zhang, J., Zhao, Q. Tags: Original Articles Source Type: research

Association of the angiotensinogen M235T polymorphism with recurrence after catheter ablation of acquired atrial fibrillation
Conclusions: The M allele of M235T might be associated with an increased risk of AF recurrence after CA. Genotyping may thus be helpful on identifying patients with higher risks of AF recurrence after CA and developing optimal follow-up strategies. These strategies may differ and should be individualized according to patients’ genotype. Future studies are warranted to validate the potential effect of AGT M235T on AF recurrence post CA. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Wang, Q., Hu, X., Li, S., Wang, X., Wang, J., Zhang, R., Sun, J., Zhang, P., Feng, X., Li, Y.-G. Tags: Original Articles Source Type: research

Association of polymorphisms in AGTR1 and AGTR2 genes with primary aldosteronism in the Chinese Han population
Conclusions: The AGTR1 rs3772616 polymorphism can be considered as a hereditary marker for primary aldosteronism, and in the Chinese Han population the rs5193 G allele seems to predispose to it only in women. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Wu, Z., Huang, C., Zhou, T., Lin, J., Zhang, K., Li, W., Zheng, J., Chen, B., Wang, B., Zhang, X., Xing, J. Tags: Original Articles Source Type: research