Bone marrow angiotensin AT2 receptor deficiency aggravates atherosclerosis development by eliminating macrophage liver X receptor-mediated anti-atherogenic actions

Conclusions:
Our findings demonstrate that BM-AT2 deficiency aggravates atherosclerosis, at least in part, by eliminating the anti-atherogenic properties of macrophages elicited by LXRβ activation.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Kato, T., Kawahito, H., Kishida, S., Irie, D., Wakana, N., Kikai, M., Takata, H., Ogata, T., Ueyama, T., Matoba, S., Yamada, H. Tags: Original Articles Source Type: research