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Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats
This study aimed to examine the protective effects of aliskiren on gentamicin-induced nephropathy. Rats were injected with gentamicin (100 mg/kg per day) for 14 days. Aliskiren was infused for two weeks. Human proximal tubular epithelial cell lines (HK-2) were cultured with gentamicin in the absence or presence of aliskiren. Inflammatory profibrotic and apoptotic markers were evaluated in vivo and in vitro. Aliskiren treatment attenuated the decreased creatinine clearance, increased fractional sodium excretion, glomerulosclerosis and tubulointerstitial fibrosis and counteracted the increased ED-1 expression in gentamicin-t...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Bae, E. H., Kim, I. J., Joo, S. Y., Kim, E. Y., Choi, J. S., Kim, C. S., Ma, S. K., Lee, J., Kim, S. W. Tags: Original Articles Source Type: research

Irbesartan-mediated AT1 receptor blockade attenuates hyposmotic-induced enhancement of I Ks current and prevents shortening of action potential duration in atrial myocytes
Conclusion: The actions of irbesartan on electrical changes induced by stretching atrial myocytes are associated with blocking AT1R. These actions may be beneficial for treating AF. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Wu, J., Ding, W.-G., Zhao, J., Zang, W.-J., Matsuura, H., Horie, M. Tags: Original Articles Source Type: research

Renin-angiotensin system in pain: Existing in a double life?
Apart from the well-documented role of the renin–angiotensin–aldosterone system (RAAS) in regulating the blood pressure and other related parameters, its role in modulating different physiological/pathological functions, including pain, has also been described. Like its dual role in regulating stress-related anxiety and cognitive functions, its dual role has also been documented in pain modulation in different disease states. Drugs blocking the RAAS activation, viz., renin inhibitors, angiotensin converting enzyme (ACE) inhibitors, AT1 receptor antagonists and aldosterone antagonists, have been shown to produce...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Bali, A., Singh, N., Jaggi, A. S. Tags: Review Article Source Type: research

Different cross-talk sites between the renin-angiotensin and the kallikrein-kinin systems
Targeting the renin–angiotensin system (RAS) constitutes a major advance in the treatment of cardiovascular diseases. Evidence indicates that angiotensin-converting enzyme inhibitors and angiotensin AT1 receptor blockers act on both the RAS and the kallikrein–kinin system (KKS). In addition to the interaction between the RAS and KKS at the level of angiotensin-converting enzyme catalyzing both angiotensin II generation and bradykinin degradation, the RAS and KKS also interact at other levels: 1) prolylcarboxypeptidase, an angiotensin II inactivating enzyme and a prekallikrein activator; 2) kallikrein, a kinin-g...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Su, J. B. Tags: Invited Review Source Type: research

The natriuretic effect of angiotensin receptor blockers is not attributable to blood pressure reduction during the previous night, but to inhibition of tubular sodium reabsorption
(Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Miura, T., Watanabe, S., Urushihara, M., Kobori, H., Fukuda, M. Tags: Letter to the Editor Source Type: research

A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility
Conclusions: C allele is a risk factor for the MI susceptibility in overall populations, and AA genotype might be a protective factor against the MI risk in overall populations. However, more case-control association investigations on larger, stratified populations are required in the future. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Feng, X., Zheng, B.-S., Shi, J.-J., Qian, J., He, W., Zhou, H.-F. Tags: Articles Source Type: research

Aldosterone synthase gene polymorphism and renal histopathologic changes in kidney transplant patients receiving a calcineurin inhibitor
Conclusion: The frequency of the different polymorphisms studied was not related to plasma aldosterone levels or the development of CIN; however, the int 2 CC genotype was related to a greater degree of interstitial fibrosis, whereas the WW genotype was related to higher CI serum levels. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Ruiz-Palacios, P. C., Rodriguez-Castellanos, F. E., Mancilla-Urrea, E., Avila-Casado, M. D. C., Inofuentes-Rivero, M. X., Rodriguez-Illana, F., Fragoso, J. M., Vargas-Alarcon, G. Tags: Articles Source Type: research

The M235T polymorphism in the angiotensinogen gene and myocardial infarction risk: A meta-analysis
Conclusions: This meta-analysis demonstrated that the AGT M235T polymorphism could be a prediction marker for risk of MI in Asians. Conclusive evidence on the effects of the variants in MI should be addressed in further studies. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Wang, Y.-J., Pan, Y. Tags: Articles Source Type: research

Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene
Conclusions: Anterior wall infarction, increased leucocyte count, decreased longitudinal strain of left ventricular and polymorphism of AGT M235T may predict remodelling after myocardial infarction. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Zaliaduonyte-Peksiene, D., Simonyte, S., Lesauskaite, V., Vaskelyte, J., Gustiene, O., Mizariene, V., Jurkevicius, R., Jariene, G., Tamosiunas, A., Zaliunas, R. Tags: Articles Source Type: research

Interplay of parathyroid hormone and aldosterone antagonist in prevention of heart failure hospitalizations in chronic kidney disease
Conclusion: Aldosterone antagonists may be helpful in preventing hospitalizations for heart failure exacerbation in CKD patients through a PTH-mediated effect. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Hassan, M., Qureshi, W., Sroujieh, L. S., Albashaireh, D., BouMalham, S., Liroff, M., Amjad, W., Khalid, F., Hadid, H., Alirhayim, Z. Tags: Articles Source Type: research

Aliskiren add-on therapy effectively reduces proteinuria in chronic kidney disease: An open-label prospective trial
Conclusions: Adding aliskiren on ACEi or ARB in CKD patients, both in diabetes and non-diabetes, has a favorable effect on reducing residual proteinuria and inadequately controlled blood pressure. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Wu, M.-T., Tung, S.-C., Hsu, K.-T., Lee, C.-T. Tags: Articles Source Type: research

Pioglitazone enhances the blood pressure-lowering effect of losartan via synergistic attenuation of angiotensin II-induced vasoconstriction
Conclusions: Our data indicate that combined treatment exerts more beneficial effects on lowering BP and improving vascular lesions. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Kong, X., Ma, M.-z., Qin, L., Zhang, Y., Li, X.-y., Wang, G.-d., Su, Q., Zhang, D.-y. Tags: Articles Source Type: research

Statins, the renin-angiotensin-aldosterone system and hypertension - a tale of another beneficial effect of statins
Conclusion: Although statins given either alone or together with antihypertensive drugs acting via the RAAS may lower arterial blood pressure, further research is needed to evaluate the mechanisms and their therapeutic significance. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Drapala, A., Sikora, M., Ufnal, M. Tags: Articles Source Type: research

Effect of all-trans retinoic acid treatment on prohibitin and renin-angiotensin-aldosterone system expression in hypoxia-induced renal tubular epithelial cell injury
Conclusion: The results suggest that ATRA acts as a positive regulator of PHB1, PHB2 and ACE2, and as a negative regulator of ACE1, angiotensin I, and angiotensin II in a RTEC model system under hypoxia/reoxygenation conditions. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Zhou, T.-B., Ou, C., Rong, L., Drummen, G. P. Tags: Articles Source Type: research

Angiotensin-converting enzyme I/D gene polymorphism affects early cardiac response to professional training in young footballers
Conclusion: Early cardiac changes in young footballers can be affected by ACE I/D polymorphism. There is a summative effect of the D allele in increasing EF and PASP in response to professional football training. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Saber-Ayad, M. M., Nassar, Y. S., Latif, I. A. Tags: Articles Source Type: research