Aldosterone synthase gene polymorphism and renal histopathologic changes in kidney transplant patients receiving a calcineurin inhibitor

Conclusion:
The frequency of the different polymorphisms studied was not related to plasma aldosterone levels or the development of CIN; however, the int 2 CC genotype was related to a greater degree of interstitial fibrosis, whereas the WW genotype was related to higher CI serum levels.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Ruiz-Palacios, P. C., Rodriguez-Castellanos, F. E., Mancilla-Urrea, E., Avila-Casado, M. D. C., Inofuentes-Rivero, M. X., Rodriguez-Illana, F., Fragoso, J. M., Vargas-Alarcon, G. Tags: Articles Source Type: research