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The renin-angiotensin system meets the hallmarks of cancer
The hallmarks of cancer are described as the distinctive and complementary capacities that cells must acquire during the multistep development of becoming a cancer cell that allow them to survive, proliferate and disseminate. The renin-angiotensin system (RAS) was first discovered and extensively studied in the physiological regulation of systemic arterial pressure. RAS signalling increases cell proliferation in malignancy by directly affecting tumour and stromal cells and by indirectly modulating the growth of vascular cells during angiogenesis. We aim to describe and give a general view of how the RAS is involved in seve...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Wegman-Ostrosky, T., Soto-Reyes, E., Vidal-Millan, S., Sanchez-Corona, J. Tags: Review Source Type: research

RETRACTED: Association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in a Caucasian population
The following articles have been retracted at the request of the Editors and the Publisher. After conducting a thorough investigation, SAGE found that the submitting authors of a number of papers published in the Journal of the Renin-Angiotensin Aldosterone System (JRAAS) (listed below) had supplied fabricated contact details for their nominated reviewers. The Editors accepted these papers based on the reports supplied by the individuals using these fake reviewer email accounts. After concluding that the peer review process was therefore seriously compromised, SAGE and the journal Editors have decided to retract all affect...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Liu, G., Zhou, T.-B., Jiang, Z., Zheng, D. Tags: Original Articles Source Type: research

Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to sarcoidosis: A meta-analysis
Conclusions: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to sarcoidosis in European and East Asian populations. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Song, G. G., Kim, J.-H., Lee, Y. H. Tags: Original Articles Source Type: research

Associations between the insertion/deletion polymorphism of the angiotensin-converting enzyme and susceptibility to aortic aneurysms: A meta-analysis
Conclusions: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to AAAs in European populations. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Song, G. G., Kim, J.-H., Lee, Y. H. Tags: Original Articles Source Type: research

Impact of interaction of cigarette smoking with angiotensin-converting enzyme polymorphisms on end-stage renal disease risk in a Han Chinese population
Conclusion: ACE I/D and ACE G2350A polymorphisms were associated with the development of ESRD. The interaction between ACE I/D polymorphism and smoking is also associated with an enhanced risk of ESRD. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Yang, H.-Y., Lu, K.-C., Fang, W.-H., Lee, H.-S., Wu, C.-C., Huang, Y.-H., Lin, Y.-F., Kao, S.-Y., Lai, C.-H., Chu, C.-M., Su, S.-L. Tags: Original Articles Source Type: research

The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis
Conclusions: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to RA, especially in Arab populations. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Song, G. G., Bae, S.-C., Kim, J.-H., Lee, Y. H. Tags: Original Articles Source Type: research

Angiotensin-converting enzyme insertion/deletion gene polymorphism and lung cancer risk: A meta-analysis
Conclusions: This meta-analysis suggests that the ACE gene I/D polymorphism may not be associated with the risk of lung cancer, and the observed increase in the risk of lung cancer may be due to small-study bias. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Wang, N., Yang, D., Ji, B., Li, J. Tags: Original Articles Source Type: research

Relationship between CYP11B2-344T>C polymorphsim and atrial fibrillation: A meta-analysis
Conclusions: Our pooled data suggest a significant association exists between CYP11B2-344T>C polymorphism and AF among hypertension populations. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Fu, X., Ma, X., Zhong, L., Song, Z. Tags: Original Articles Source Type: research

Adiponectin gene polymorphisms contributes to ischemic stroke risk: A meta-analysis
Conclusion: The present study suggested that rs2241766 polymorphism of adiponectin gene was associated with the risk for ischemic stroke. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Shen, D., Xing, S., Chen, C. Tags: Original Articles Source Type: research

Genetic combination of angiotensin-converting enzyme with methylene tetrahydrofolate reductase polymorphisms and the risk of type 2 diabetes mellitus in Bahrain
Conclusions: The results clearly showed an association of the ACE I/D polymorphism with the progression of T2DM, but when it interacts with MTHFR polymorphism no influence was detected on the increased risk of T2DM. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Al-Harbi, E. M., Farid, E. M., Gumaa, K. A., Darwish, A. H., Alenizi, M., Singh, J. Tags: Original Articles Source Type: research

Association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in a Caucasian population
Conclusions: ACE I/D gene polymorphism was not associated with T2DN susceptibility and the risk of patients with T2DM developing T2DN in Caucasian populations. However, more studies should be performed in the future. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Liu, G., Zhou, T.-B., Jiang, Z., Zheng, D. Tags: Original Articles Source Type: research

Urinary angiotensin-converting enzyme 2 increases in diabetic nephropathy by angiotensin II type 1 receptor blocker olmesartan
Conclusion: Olmesartan may have the unique effect of increasing urinary ACE2 levels. However, whether this contributes to olmesartan’s renoprotective effect must be examined further. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Abe, M., Oikawa, O., Okada, K., Soma, M. Tags: Original Articles Source Type: research

Serum prorenin levels are not associated with ocular diseases in non-diabetic subjects
Conclusion: Considering the current results and those of previous studies together, we found that the prorenin value is useful solely for predicting development of diabetic retinopathy in adults. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Yokota, H., Nagaoka, T., Sato, E., Takahashi, A., Shimouchi, A., Yoshida, A. Tags: Original Articles Source Type: research

Management of renin-angiotensin system blockade in patients with chronic kidney disease under specialist care. Retrospective cross-sectional study
Conclusion: The use of RAAS blocking agents were increasing in CKD patients under specialist care between 1996–2011. The quality of the management was gradually improved. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Tylicki, L., Jakubowska, A., Lizakowski, S., Świetlik, D., Rutkowski, B. Tags: Original Articles Source Type: research

Serum dehydroepiandrosterone sulfate concentration is lower in women with primary aldosteronism
Conclusion: Our data suggested that serum DHEA-S levels are lower in women with PA. In subtype groups, only women with APA had lower serum DHEA-S. There was no significant difference between subjects with bilateral essential hyperplasia, PA with negative imaging findings, normal controls and subjects with essential hypertension in both genders. The serum DHEA-S level is negatively correlated with the size of APA. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Chen, A.-H., Li, H.-Y., Wu, V.-c., Lin, Y.-H., Huang, T.-S., (and the Taiwan Primary Aldosteronism Investigation (TAIPAI) Study Group) Tags: Original Articles Source Type: research