Journal of the Renin-Angiotensin-Aldosterone System : JRAAS This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Impact of electrocardiographic findings for diagnosis of left ventricular hypertrophy in patients with primary aldosteronism
Conclusions: ECG indexes had a reasonably high specificity, but a low sensitivity for LVH in patients with primary aldosteronism. Cornell voltage index and Cornell product index had a better diagnostic value of LVH, and had a better correlation with LVM index in these patients. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Kurisu, S., Iwasaki, T., Mitsuba, N., Ishibashi, K., Dohi, Y., Kihara, Y. Tags: Original Articles Source Type: research

Increased circulatory RAS activity can be inhibited by statins in patients with hypercholesterolemia
Conclusions: In HC patients, lowering serum cholesterol with statins is associated with decreased circulatory RAS activity. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Long, H., Wang, L., Su, H., Xu, J., Li, J., Peng, Q., Dong, Y., Cheng, X. Tags: Original Articles Source Type: research

Importance of the time of initiation of mineralocorticoid receptor antagonists on risk of mortality in patients with heart failure
Conclusions: Delay of MRA initiation up to 30 to 90 days after discharge implies a significant increase in mortality compared with MRA initiation at discharge, after a first episode of decompensate congestive HF. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Rossi, R., Crupi, N., Coppi, F., Monopoli, D., Sgura, F. Tags: Original Articles Source Type: research

Evaluation of spironolactone plus hydrochlorothiazide in reducing proteinuria in type 2 diabetic nephropathy
Conclusion: Our results showed that spironolactone plus hydrochlorothiazide is an effective and inexpensive modality in the treatment of diabetic nephropathy without increasing serum potassium. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Momeni, A., Behradmanesh, M. S., Kheiri, S., Karami Horestani, M. Tags: Original Articles Source Type: research

Ameliorative potential of angiotensin-converting enzyme inhibitor (ramipril) on chronic constriction injury of sciatic nerve induced neuropathic pain in mice
Conclusion: It may be concluded that angiotensin-converting enzyme inhibitor may be a potential new target for the management of neuropathic pain. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Kaur, P., Muthuraman, A., Kaur, J. Tags: Original Articles Source Type: research

Effects of angiotensin II blockade on cardiomyocyte regeneration after myocardial infarction in rats
Conclusions: The number of newly formed cardiomyocytes increased after MI. Angiotensin II blockade neither stimulated nor prevented cardiomyocyte regeneration. ARB treatment increased vascular densities in the infarct border zone and modulated remodelling of the non-infarcted myocardium preventing effectively post-MI cardiac hypertrophy. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Segersvard, H., Lakkisto, P., Forsten, H., Immonen, K., Kosonen, R., Palojoki, E., Kankuri, E., Harjula, A., Laine, M., Tikkanen, I. Tags: Original Articles Source Type: research

Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2
Conclusions: Previously ATIP has been shown to inhibit growth factor signalling in cancerous cells via an interaction with the AT2-receptor. This is the first report to identify that ATIP may have a similar role in other disease states characterised by excessive growth and indicates that for ATIP3, at least, an interaction with the AT2-receptor may not be necessary. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Varghayee, N., Krezel, M. A., Rezmann, L., Chow, L., Frauman, A. G., Louis, W. J., Louis, S. N. Tags: Original Articles Source Type: research

Transplantation of periaortic adipose tissue from angiotensin receptor blocker-treated mice markedly ameliorates atherosclerosis development in apoE-/- mice
Conclusions: Our findings demonstrated that AT1 receptor plays a crucial role in HCD-induced phenotypic alterations of tPAT, modulation of which could exert beneficial effects on atherosclerosis. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Irie, D., Kawahito, H., Wakana, N., Kato, T., Kishida, S., Kikai, M., Ogata, T., Ikeda, K., Ueyama, T., Matoba, S., Yamada, H. Tags: Original Articles Source Type: research

Expression of classical components of the renin-angiotensin system in the human eye
Conclusion: This study describes the distribution of RAS in the normal adult human eye and demonstrates the existence of an independent ocular RAS, with uveal and retinal tissues showing the highest expression of RAS components. These preliminary findings provide scope for examination of additional components of this system in the human eye, as well as possible differential expression under pathological conditions. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: White, A. J., Cheruvu, S. C., Sarris, M., Liyanage, S. S., Lumbers, E., Chui, J., Wakefield, D., McCluskey, P. J. Tags: Original Articles Source Type: research

Impact of taurine supplementation on blood pressure in gestational protein-restricted offspring: Effect on the medial solitary tract nucleus cell numbers, angiotensin receptors, and renal sodium handling
Conclusion: The present investigation shows a decreased FENa that occurs despite unchanged creatinine clearance. It is plausible to hypothesize an association of decreased postnatal nTS cell number, AT1R/AT2R ratio and FENa with the higher blood pressure levels found in taurine-deficient progeny (LP) compared with age-matched NP and LPT offspring. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Scabora, J. E., de Lima, M. C., Lopes, A., de Lima, I. P., Mesquita, F. F., Torres, D. B., Boer, P. A., Gontijo, J. A. R. Tags: Original Articles Source Type: research

Fetal kidney programming by severe food restriction: Effects on structure, hormonal receptor expression and urinary sodium excretion in rats
Conclusion: The current data suggest that changes in renal function are conducive to excess sodium tubule reabsorption, and this might potentiate the programming of adult hypertension. It is plausible to arise in the current study an association between decreasing natriuresis, reciprocal changes in renal AngII and steroid receptors with the hypertension development found in FR50% compared with age-matched NF offspring. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Vaccari, B., Mesquita, F. F., Gontijo, J. A., Boer, P. A. Tags: Original Articles Source Type: research

Angiotensin II, via angiotensin receptor type 1/nuclear factor-{kappa}B activation, causes a synergistic effect on interleukin-1-{beta}-induced inflammatory responses in cultured mesangial cells
Conclusions: These data indicates that Ang II, via AT1/NF-B pathway activation, cooperates with IL-β to increase the inflammatory response in mesangial cells. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Alique, M., Sanchez-Lopez, E., Rayego-Mateos, S., Egido, J., Ortiz, A., Ruiz-Ortega, M. Tags: Original Articles Source Type: research

Effects of acute angiotensin II on ischemia reperfusion injury following myocardial infarction
Myocardial infarction (MI) induces cardiac remodeling. This may increase the susceptibility of the infarcted heart to subsequent ischemic events. While chronic angiotensin II blockade is cardioprotective post-MI, the acute effects of angiotensin II in ischemia-reperfusion injury (IR) remains unclear. In the present study, we tested whether angiotensin II administration altered recovery of left ventricular (LV) function to IR in hearts from sham and MI rats. Echocardiography, LV pressure-volume relationships, and IR performance were established in subsets of sham (N = 27) and MI hearts (N = 41). IR was conducted in red-cell...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Mann, S., Bajulaiye, A., Sturgeon, K., Sabri, A., Muthukumaran, G., Libonati, J. R. Tags: Original Articles Source Type: research

Effects of olmesartan therapy on the expression of lung adrenoceptors in rats with chronic heart failure
Conclusion: Olmesartan may play a beneficial role in protecting lung in CHF by up-regulating AR and decreasing levels of PRA and Ang II. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Li, Y., Jiang, Z., Cao, F., Liu, F. Tags: Original Articles Source Type: research

Role of MiR-30a in cardiomyocyte autophagy induced by Angiotensin II
Conclusion: These studies provided evidence that MiR-30a plays an important role in regulating autophagy through the Beclin-1 protein, during myocardial injury induced by Ang II. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 2, 2015 Category: Biomedical Science Authors: Huang, J., Huang, C., Luo, Y., Liu, S., Chen, X. Tags: Original Articles Source Type: research