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Meta-analysis of the association between angiotensin-converting enzyme I/D polymorphism and aortic aneurysm risk
Conclusions: In conclusion, this meta-analysis suggested that ACE I/D polymorphism is a risk factor for AA. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Song, Y., Miao, R., Wang, H., Qin, X., Zhang, Y., Miao, C., Wang, Z. Tags: Original Articles Source Type: research

Losartan treating podocyte injury induced by Ang II via downregulation of TRPC6 in podocytes
Conclusion: These findings maybe provide an ideal drug target for the diagnosis and treatment of acquired glomerular diseases. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Chi-Xianggeng, , Hu-Bo, , Yu, S., Yin-Lianghong, , Meng-Yu, , Wang-Boxun, , Yang-Jinsheng, , Lin-Jiahui, , Huang-Dexu, , Chen-lanlan, Tags: Original Articles Source Type: research

Long-term effects of adrenalectomy or spironolactone on blood pressure control and regression of left ventricle hypertrophy in patients with primary aldosteronism
Conclusions: Although both surgical and conservative treatment can induce a long-term decrease of blood pressure, adrenalectomy seems to be more effective in reduction of LV mass, as it reverses both wall thickening and enlargement of the LV cavity. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Indra, T., Holaj, R., Strauch, B., Rosa, J., Petrak, O., Somloova, Z., Widimsky, J. Tags: Original Articles Source Type: research

Local expression of AP/AngIV/IRAP and effect of AngIV on glucose-induced epithelial transport in human jejunal mucosa
Conclusion: The present study indicates the presence of substrates and enzymes necessary for AngIV formation as well as the receptor IRAP in the jejunal mucosa. The functional data suggest that AngIV regulates glucose uptake in the healthy human small intestine. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Malinauskas, M., Wallenius, V., Fändriks, L., Casselbrant, A. Tags: Original Articles Source Type: research

Lack of association of angiotensin-converting enzyme insertion/deletion polymorphism with breast cancer: An update meta-analysis based on 10405 subjects
Conclusion: We concluded that ACE gene I/D polymorphism was not associated with breast cancer. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Li, X.-L., Zheng, Z.-J., Qu, H.-O. Tags: Original Articles Source Type: research

Eplerenone reduces arterial thrombosis in diabetic rats
Conclusions: Our study demonstrated the antithrombotic effect of EPL manifested by a decrease in the dynamics of thrombus formation and changes in its structure. The changes in thrombosis process were accompanied by antihaemostatic, profibrinolytic and anti-inflammatory effects. The aldosterone blockade with EPL seems to be an additional pharmacological strategy for the prevention and treatment of thrombotic disorders in diabetes. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Zakrzeska, A., Gromotowicz-Popławska, A., Szemraj, J., Szoka, P., Kisiel, W., Purta, T., Kasacka, I., Chabielska, E. Tags: Original Articles Source Type: research

Efficacy and safety of combination therapy of high-dose losartan and hydrochlorothiazide in patients with hypertension
Conclusion: Combination therapy with high-dose losartan and HCTZ was superior to the combination of telmisartan and HCTZ with respect to significant decreases in systolic blood pressure and serum uric acid in hypertensive patients. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Shiga, Y., Miura, S.-i., Norimatsu, K., Hitaka, Y., Nagata, I., Koyoshi, R., Morii, J., Kuwano, T., Uehara, Y., Inoue, A., Shirotani, T., Fujisawa, K., Matsunaga, E., Saku, K. Tags: Original Articles Source Type: research

Effects of the angiotensin-(1-7)/Mas/PI3K/Akt/nitric oxide axis and the possible role of atrial natriuretic peptide in an acute atrial tachycardia canine model
Conclusion: Angiotensin-(1-7) prevented acute electrical remodeling in canines with acute atrial tachycardia via the angiotensin-(1-7)/Mas/PI3K/Akt/NO signaling pathway. ANP was related to the anti-arrhythmic effects of angiotensin-(1-7). (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Zhao, J., Liu, E., Li, G., Qi, L., Li, J., Yang, W. Tags: Original Articles Source Type: research

Effects of telmisartan on lipid metabolisms and proinflammatory factors secretion of differentiated 3T3-L1 adipocytes
Conclusions: Telmisartan affected lipometabolisms and the proinflammatory factors secreted from adipocytes. Nos3, CPT1α and the MAPK pathway being affected by telmisartan may be the underlying cause of the improvement in lipid metabolisms and secretion of proinflammatory factors of differentiated 3T3-L1 adipocytes. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Kang, C., Yijun, L., Jingtao, D., Changyu, P., Wenhua, Y., Baoan, W., Fangling, M., Xianling, W., Guoqing, Y., Yiming, M., Juming, L. Tags: Original Articles Source Type: research

Effects of exercise on central aortic pressure before and after treatment with renin-angiotensin system blockade in patients with hypertension
Conclusion: Blood pressure lowering does not directly influence the relationship between aortic and brachial pressure either at rest or during exercise in patients with hypertension, other than through proportionate lowering of both pressures. These effects remained unchanged 48 hours after a simulated missed medication dose. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Lacy, P. S., Brunel, P., Baschiera, F., Botha, J., Williams, B. Tags: Original Articles Source Type: research

Effects of curcumin on angiotensin-converting enzyme gene expression, oxidative stress and anti-oxidant status in thioacetamide-induced hepatotoxicity
Conclusion: Curcumin treatment reduced oxidative stress in animals by scavenging reactive oxygen species, protecting the anti-oxidant enzymes from being denatured and reducing the oxidative stress marker lipid peroxidation. Curcumin treatment restores hepatocytes, damaged by TAA, and protects liver tissue approaching cirrhosis. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Fazal, Y., Fatima, S. N., Shahid, S. M., Mahboob, T. Tags: Original Articles Source Type: research

Effects of angiotensin II receptor blockade on cerebral, cardiovascular, counter-regulatory, and symptomatic responses during hypoglycaemia in patients with type 1 diabetes
Conclusion: In conclusion candesartan has no effect on cerebral function during mild experimental hypoglycaemia in subjects with type 1 diabetes and high RAS activity. Candesartan may reduce glucose utilisation or increase endogenous glucose production during hypoglycaemia. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Faerch, L. H., Thorsteinsson, B., Tarnow, L., Holst, J. J., Kjaer, T., Kanters, J., Larroude, C., Dela, F., Pedersen-Bjergaard, U. Tags: Original Articles Source Type: research

Effects of a restricted fetal growth environment on human kidney morphology, cell apoptosis and gene expression
Conclusions: Our study suggested increased apoptosis and decreased renin and angiotensinogen expression during human kidney development in an FGR environment. The current results will be helpful to further explore the molecular mechanism of FGR and facilitate future studies of hypertension and cardiovascular diseases and the establishment of preventive methods. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Wang, Y.-P., Chen, X., Zhang, Z.-K., Cui, H.-Y., Wang, P., Wang, Y. Tags: Original Articles Source Type: research

Effect of angiotensin-converting enzyme gene insertion/deletion polymorphism and angiotensin-converting enzyme inhibition on erythropoiesis in patients on haemodialysis
Conclusion: These results indicate that ACEi therapy may increase erythropoietin resistance and worsen erythropoiesis in haemodialysis patients with the D allele. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Kiss, Z., Ambrus, C., Kulcsar, I., Szegedi, J., Kiss, I., on behalf of the ACEGENE-BB_HU workgroup, Benke, Borbas, Ferenczi, Hengsperger, Kazup, Nagy, Nemeth, Rozinka, Szabo, Szelestei, Toth, Varga, Wagner, Zakar Tags: Original Articles Source Type: research

Early urinary angiotensinogen excretion in critically ill neonates
Conclusions: The urinary angiotensinogen level correlates with the overall maturity of renal function during the early postnatal period in critically ill neonates and an increased urinary angiotensinogen level might reflect renal injury in immature neonates. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Wang, Q., Li, M., Li, X., Pan, J., Wang, J., Feng, X., Li, Y. Tags: Original Articles Source Type: research