Irbesartan-mediated AT1 receptor blockade attenuates hyposmotic-induced enhancement of I Ks current and prevents shortening of action potential duration in atrial myocytes

Conclusion:
The actions of irbesartan on electrical changes induced by stretching atrial myocytes are associated with blocking AT1R. These actions may be beneficial for treating AF.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Wu, J., Ding, W.-G., Zhao, J., Zang, W.-J., Matsuura, H., Horie, M. Tags: Original Articles Source Type: research