ACE2 activity was increased in atherosclerotic plaque by losartan: Possible relation to anti-atherosclerosis

Conclusions:
The results showed that ACE2 activity was regulated in atherosclerotic plaque by losartan, which may play an important role in treatment of atherosclerosis. The mechanism involves Ang II–AT1R-mediated mitogen-activated protein kinases, MAPKs (MAPKs) signaling pathway.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Zhang, Y. H., Hao, Q. Q., Wang, X. Y., Chen, X., Wang, N., Zhu, L., Li, S. Y., Yu, Q. t., Dong, B. Tags: Original Articles Source Type: research