Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury

Conclusion:
This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR and increases the deleterious ACE/Ang II/AT1R axis of the renal RAS in mice. Further, AT2KO mice are more susceptible to HFD-induced renal injury.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 4, 2016 Category: Biomedical Science Authors: Ali, Q., Dhande, I., Samuel, P., Hussain, T. Tags: Original Article Source Type: research