Treatment with irbesatan may improve slit diaphragm alterations in rats with adriamycin-induced nephropathy

Conclusions:
For rats with adriamycin-induced nephropathy, irbesartan could significantly reduce proteinuria. As a possible mechanism, irbesartan may improve the slit diaphragm protein of the glomerular podocyte and stabilize the cytoskeleton of the podocyte.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - May 10, 2016 Category: Biomedical Science Authors: Wang, N., Wei, R.-b., Li, P., Li, Q.-p., Yang, X., Yang, Y., Huang, M.-j., Wang, R., Yin, Z., Lv, Y., Chen, X.-m. Tags: Original Article Source Type: research