Addition of hydrochlorothiazide to angiotensin receptor blocker therapy can achieve a lower sodium balance with no acceleration of intrarenal renin angiotensin system in patients with chronic kidney disease

Conclusions:
Lower Na balance was produced by add-on HCTZ to ARB treatment without an increase of intra-renal renin-angiotensin system activity, leading to restoration of nocturnal hypertension. A further study is needed to demonstrate that the reduction of UAGTV by additional diuretics to ARBs prevents the progression of nephropathy or cardiovascular events.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 8, 2016 Category: Biomedical Science Authors: Fuwa, D., Fukuda, M., Ogiyama, Y., Sato, R., Mizuno, M., Miura, T., Abe-Dohmae, S., Michikawa, M., Kobori, H., Ohte, N. Tags: Original Article Source Type: research