Journal of Biomaterials Applications This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Highly cytocompatible and flexible three-dimensional graphene/polydimethylsiloxane composite for culture and electrochemical detection of L929 fibroblast cells
Recently, three-dimensional graphene interconnected network has attracted great interest as a scaffold structure for tissue engineering due to its high biocompatibility, high electrical conductivity, high specific surface area and high porosity. However, free-standing three-dimensional graphene exhibits poor flexibility and stability due to ease of disintegration during processing. In this work, three-dimensional graphene is composited with polydimethylsiloxane to improve the structural flexibility and stability by a new simple two-step process comprising dip coating of polydimethylsiloxane on chemical vapor deposited grap...
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Waiwijit, U., Maturos, T., Pakapongpan, S., Phokharatkul, D., Wisitsoraat, A., Tuantranont, A. Tags: Functional Biomaterials Surfaces Source Type: research

Effects of Ti-C:H coating and plasma nitriding treatment on tribological, electrochemical, and biocompatibility properties of AISI 316L
Ti–C:H coatings were deposited on original, nitrided, and polished-nitrided AISI 316L stainless steel substrates using a closed field unbalanced magnetron sputtering system. Sliding friction wear tests were performed in 0.89 wt.% NaCl solution under a load of 30 N against AISI 316L stainless steel, Si3N4, and Ti6Al4V balls, respectively. The electrochemical properties of the various specimens were investigated by means of corrosion tests performed in 0.89 wt.% NaCl solution at room temperature. Finally, the biocompatibility properties of the specimens were investigated by performing cell culturing experiments using p...
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Kao, W., Su, Y., Horng, J., Zhang, K. Tags: Functional Biomaterials Surfaces Source Type: research

Antibacterial and biological properties of biofunctionalized nanocomposites on titanium for implant application
In this study, we demonstrate a simple one-step, water-based procedure for the fabrication of biofunctionalized nanocomposites on titanium for implant application. The formation of biofunctionalized silver nanoparticles with varied biomolecule templates is confirmed by Fourier-transform infrared spectroscopic, contact angle, field-emission scanning electron microscopy, and inductively coupled plasma atomic emission spectrometry analysis. Antibacterial properties of the specimens were determined by challenging them against Staphylococcus aureus. The Ag-incorporated titanium shows excellent antibacterial ability against plan...
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Li, P., Tong, Z., Huo, L., Yang, F., Su, W. Tags: Functional Biomaterials Surfaces Source Type: research

Genipin-crosslinked O-carboxymethyl chitosan-gum Arabic coacervate as a pH-sensitive delivery system and microstructure characterization
The possibility of genipin-crosslinked O-carboxymethyl chitosan–gum Arabic coacervate as a pH-sensitive delivery vehicle was investigated. O-carboxymethyl chitosan–gum Arabic coacervates separated in pH 3.0, 4.5, and 6.0 were crosslinked by genipin for different durations and the crosslinked products were subjected to crosslinking degree, swelling behavior, bovine serum albumin release profile, and microstructure characterization. Genipin-crosslinking greatly improved the stability of the coacervates against the simulated gastric solution and created certain pH-sensitivity. The coacervates displayed higher swel...
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Huang, G.-Q., Cheng, L.-Y., Xiao, J.-X., Wang, S.-Q., Han, X.-N. Tags: Biomaterials Processing Source Type: research

Fabrication and evaluation of electrohydrodynamic jet 3D printed polycaprolactone/chitosan cell carriers using human embryonic stem cell-derived fibroblasts
Biological function of adherent cells depends on the cell–cell and cell–matrix interactions in three-dimensional space. To understand the behavior of cells in 3D environment and their interactions with neighboring cells and matrix requires 3D culture systems. Here, we present a novel 3D cell carrier scaffold that provides an environment for routine 3D cell growth in vitro. We have developed thin, mechanically stable electrohydrodynamic jet (E-jet) 3D printed polycaprolactone and polycaprolactone/Chitosan macroporous scaffolds with precise fiber orientation for basic 3D cell culture application. We have eva...
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Wu, Y., Sriram, G., Fawzy, A. S., Fuh, J. Y., Rosa, V., Cao, T., Wong, Y. S. Tags: Biomaterials Processing Source Type: research

Bioactivity of Y2O3 and CeO2 doped SiO2-SrO-Na2O glass-ceramics
The bioactivity of yttrium and cerium are investigated when substituted for Sodium (Na) in a 0.52SiO2-0.24SrO-0.24-xNa2O-xMO glass-ceramics (where x = 0.08 and MO = Y2O3 or CeO2). Bioactivity is monitored through pH and inductively coupled plasma-optical emission spectrometry where pH of simulated body fluid ranged from 7.5 to 7.6 and increased between 8.2 and 10.0 after 14-day incubation with the glass-ceramic disks. Calcium (Ca) and phosphorus (P) levels in simulated body fluid after incubation with yttrium and cerium containing disks show a continual decline over the 14-day period. In contrast, Con disks (not containing...
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Placek, L., Keenan, T., Wren, A. Tags: Biomaterials Processing Source Type: research

Design, fabrication and characterization of oxidized alginate-gelatin hydrogels for muscle tissue engineering applications
In this study, we reported the preparation of self cross-linked oxidized alginate–gelatin hydrogels for muscle tissue engineering. The effect of oxidation degree (OD) and oxidized alginate/gelatin (OA/GEL) weight ratio were examined and the results showed that in the constant OA/GEL weight ratio, both cross-linking density and Young’s modulus enhanced by increasing OD due to increment of aldehyde groups. Furthermore, the degradation rate was increased with increasing OD probably due to decrement in alginate molecular weight during oxidation reaction facilitated degradation of alginate chains. MTT cytotoxicity a...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Baniasadi, H., Mashayekhan, S., Fadaoddini, S., Haghirsharifzamini, Y. Tags: Soft Tissues and Materials Source Type: research

Synthesis, characterization and biological evaluation of strontium/magnesium-co-substituted hydroxyapatite
The present study aims to investigate the contribution of two biologically important cations, Mg2+ and Sr2+, when co-substituted into the structure of hydroxyapatite (Ca10(PO4)6(OH)2, HA). The substituted samples were synthesized by a hydrothermal method that involved the addition of Mg2+ and Sr2+ containing precursors to partially replace Ca2+ in the apatite structure. Four co-substituted HA samples with different concentrations of Mg2+ and Sr2+ ((Mg + Sr)/(Mg + Sr + Ca) = 30%) were investigated, and they were compared with pure HA. Experimental results showed that only a limited amount of Mg (Mg/(Mg + Ca + Sr) < 14%) ...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Geng, Z., Wang, R., Li, Z., Cui, Z., Zhu, S., Liang, Y., Liu, Y., Huijing, B., Li, X., Huo, Q., Liu, Z., Yang, X. Tags: Biomaterials Processing Source Type: research

Improving PEEK bioactivity for craniofacial reconstruction using a 3D printed scaffold embedded with mesenchymal stem cells
Conclusions This study demonstrates for the first time that SLS 3D printing can be used to fabricate customized porous PEEK scaffolds that maintain the viability of adipose and bone marrow-derived MSCs and induce the osteodifferentiation of the adipose-derived MSCs. The combination of 3D printed PEEK scaffolds with MSCs could overcome some of the limitations using PEEK biopolymers for load-bearing bone regeneration in craniofacial reconstruction. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Roskies, M., Jordan, J. O., Fang, D., Abdallah, M.-N., Hier, M. P., Mlynarek, A., Tamimi, F., Tran, S. D. Tags: Biomaterials Processing Source Type: research

Periodontal regeneration with stem cells-seeded collagen-hydroxyapatite scaffold
In this study, the periodontal regeneration capability of collagen-hydroxyapatite scaffolds, seeded with bone marrow stem cells, was investigated in a canine labial alveolar bone defect model. Bone marrow stem cells were isolated, expanded and characterized. Porous collagen-hydroxyapatite scaffold and cross-linked collagen-hydroxyapatite scaffold were prepared. Attachment, migration, proliferation and morphology of bone marrow stem cells, co-cultured with porous collagen-hydroxyapatite or cross-linked collagen-hydroxyapatite, were evaluated in vitro. The periodontal regeneration capability of collagen-hydroxyapatite scaffo...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Liu, Z., Yin, X., Ye, Q., He, W., Ge, M., Zhou, X., Hu, J., Zou, S. Tags: Hard Tissues and Materials Source Type: research

Influence of artificially-induced porosity on the compressive strength of calcium phosphate bone cements
The biological and mechanical nature of calcium phosphate cements (CPC's) matches well with that of bone tissues, thus they can be considered as an appropriate environment for bone repair as bone defect fillers. The current study focuses on the experimental characterization of the mechanical properties of CPCs that are favorably used in clinical applications. Aiming on evaluation of their mechanical performance, tests in compression loading were conducted in order to determine the mechanical properties of the material under study. In this context, experimental results occurring from the above mechanical tests on porous spe...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Mouzakis, D., Zaoutsos, S. P., Bouropoulos, N., Rokidi, S., Papanicolaou, G. Tags: Hard Tissues and Materials Source Type: research

Poly ({gamma}-glutamic acid)/beta-TCP nanocomposites via in situ copolymerization: Preparation and characterization
A series biodegradable poly (-glutamic acid)/beta-tricalcium phosphate (-PGA/TCP) nanocomposites were prepared which were composed of poly--glutamic acid polymerized in situ with β-tricalcium phosphate and physiochemically characterized as bone graft substitutes. The particle size via dynamic light scattering, the direct morphological characterization via transmission electron microscopy and field emission scanning electron microscope, which showed that -PGA and β-TCP were combined compactly at 80℃, and the -PGA/TCP nanocomposites had homogenous and nano-sized grains with narrow particle size distributions...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Shu, X.-l., Shi, Q.-s., Feng, J., Yang, Y.-h., Zhou, G., Li, W.-r. Tags: Hard Tissues and Materials Source Type: research

The enhancement of chondrogenesis of ATDC5 cells in RGD-immobilized microcavitary alginate hydrogels
In our previous work, we have developed an effective microcavitary alginate hydrogel for proliferation of chondrocytes and maintenance of chondrocytic phenotype. In present work, we investigated whether microcavitary alginate hydrogel could promote the chondrogenesis of progenitor cells. Moreover, we attempted to further optimize this system by incorporating synthetic Arg-Gly-Asp peptide. ATDC5 cells were seeded into microcavitary alginate hydrogel with or without Arg-Gly-Asp immobilization. Cell Counting Kit-8 and live/dead staining were conducted to analyze cell proliferation. Real-time polymerase chain reaction (RT-PCR)...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Yao, Y., Zeng, L., Huang, Y. Tags: Hard Tissues and Materials Source Type: research

Nanofibrous poly(3-hydroxybutyrate)/poly(3-hydroxyoctanoate) scaffolds provide a functional microenvironment for cartilage repair
Articular cartilage defects, when repaired ineffectively, often lead to further deterioration of the tissue, secondary osteoarthritis and, ultimately, joint replacement. Unfortunately, current surgical procedures are unable to restore normal cartilage function. Tissue engineering of cartilage provides promising strategies for the regeneration of damaged articular cartilage. As yet, there are still significant challenges that need to be overcome to match the long-term mechanical stability and durability of native cartilage. Using electrospinning of different blends of biodegradable poly(3-hydroxybutyrate)/poly(3-hydroxyocta...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Ching, K. Y., Andriotis, O. G., Li, S., Basnett, P., Su, B., Roy, I., Tare, R. S., Sengers, B. G., Stolz, M. Tags: Hard Tissues and Materials Source Type: research

Surface PEGylation of intraocular lens for PCO prevention: An in vivo evaluation
Posterior capsular opacification (PCO) is a common complication in cataract surgery. The development of PCO is attributed to the combination of adhesion, migration, proliferation, and transdifferentiation of the residual lens epithelial cells (LEC) onto the interface of intraocular lens (IOL) material and lens posterior, in which the initial adhesion is the beginning step and plays important roles. In the present study, hydrophilic polyethylene glycol (PEG) was immobilized onto IOL surface via plasma-aided chemical grafting procedure. The attenuated total reflection – Fourier transform infrared (ATR-FTIR) and contact...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Xu, X., Tang, J.-M., Han, Y.-M., Wang, W., Chen, H., Lin, Q.-K. Tags: Functional Biomaterials Surfaces Source Type: research