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Using glucosamine to improve the properties of photocrosslinked gelatin scaffolds
The use of hydrogel-based cell transport scaffolds holds great promise in regenerative medicine, such as treating osteoarthritis. Gelatin and glucosamine are the ideal materials to be used in the hydrogel scaffolds for cartilage regeneration for they could act as compositions of cartilage. To overcome the weak strength of traditional gelatin hydrogels and down-regulate cell toxicity of glucosamine, gelatin and glucosamine molecules were grafted with acrylate groups and covalently crosslinked under photo-radiation to form hydrogels. Hydrogels with tuning physiochemical properties were produced according to different proport...
Source: Journal of Biomaterials Applications - January 8, 2015 Category: Materials Science Authors: Suo, H., Xu, K., Zheng, X. Tags: Hard Tissues and Materials Source Type: research

Evaluation of bone repair of critical size defects treated with simvastatin-loaded poly(lactic-co-glycolic acid) microspheres in rat calvaria
Conclusions The repair of critical size bone defects was accelerated and enhanced by the implantation of simvastatin-loaded PLGA microspheres. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - January 8, 2015 Category: Materials Science Authors: Ferreira, L. B., Bradaschia-Correa, V., Moreira, M. M., Marques, N. D., Arana-Chavez, V. E. Tags: Hard Tissues and Materials Source Type: research

Effects of bioactive cements incorporating zinc-bioglass nanoparticles on odontogenic and angiogenic potential of human dental pulp cells
Conclusions Our results demonstrate that ZnBG incorporated within CPCs activates odontogenic differentiation and promotes angiogenesis in vitro through integrin, Wnt, MAPK, and NF-B pathways. Thus, CPCs incorporating ZnBG are promising matrices in tissue engineering to stimulate endodontic regeneration. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - January 8, 2015 Category: Materials Science Authors: Zhang, J., Park, Y.-D., Bae, W.-J., El-Fiqi, A., Shin, S.-H., Lee, E.-J., Kim, H.-W., Kim, E.-C. Tags: Composites Source Type: research

Conjugation of poly(amidoamine) dendrimers with various acrylates for improved delivery of plasmid encoding interleukin-12 gene
In this study, a small library of polyamidoamine (PAMAM) derivatives was prepared through the conjugation of its amines with various acrylates containing 5–21 carbon chain lengths at two different conjugation degrees, and the ability of the nano-sized PAMAM-based complexes to transfer the plasmid encoding interleukin-12 (IL-12) gene into the cells was studied. As the wide clinical application of the recombinant IL-12 protein has been limited due to several deaths reported following the systemic administration of the protein, local expression of the IL-12 gene inside the tumor target has been considered as an effectiv...
Source: Journal of Biomaterials Applications - January 8, 2015 Category: Materials Science Authors: Sabahi, Z., Samani, S. M., Dehshahri, A. Tags: Functional Biomaterials Surfaces Source Type: research

In vivo efficacy for novel combined anticalcification treatment of glutaraldehyde-fixed cardiac xenograft using humanized mice
This study aimed to assess the in vivo effect of our novel combined anticalcification treatment, which includes immunologic modification, using α1,3-galactosyltransferase knock-out mice to mimic human immunologic environment. Bovine pericardia were cross-linked with GA and treated with decellularization, immunologic modification with α-galactosidase, space-filler with polyethylene glycol, organic solvent, and detoxification. The bovine pericardia were subcutaneously implanted into humanized and wild type mice, and titers of anti α-Gal IgM and IgG were evaluated at various time intervals. In vivo...
Source: Journal of Biomaterials Applications - January 8, 2015 Category: Materials Science Authors: Lim, H.-G., Choi, S. Y., Jeong, S., Shin, J.-S., Park, C.-G., Kim, Y. J. Tags: Functional Biomaterials Surfaces Source Type: research

Laser surface modification of AZ31B Mg alloy for bio-wettability
Magnesium alloys are the potential degradable materials for load-bearing implant application due to their comparable mechanical properties to human bone, excellent bioactivity, and in vivo non-toxicity. However, for a successful load-bearing implant, the surface of bio-implant must allow protein absorption and layer formation under physiological environment that can assist the cell/osteoblast growth. In this regard, surface wettability of bio-implant plays a key role to dictate the quantity of protein absorption. In light of this, the main objective of the present study was to produce favorable bio-wettability conditi...
Source: Journal of Biomaterials Applications - January 8, 2015 Category: Materials Science Authors: Ho, Y.-H., Vora, H. D., Dahotre, N. B. Tags: Biomaterials Processing Source Type: research

Corrigendum
Lebourg M, Martínez-Díaz S, García-Giralt N, Torres-Claramunt R, Ribelles JL, Vila-Canet G, Monllau JC. (2014) Cell-free cartilage engineering approachusing hyaluronic acid–polycaprolactone scaffolds: A study in vivo. Journal of Biomaterials Applications 28(9): 1304–1315. (Original DOI: 10.1177/0885328213507298) In this article author J. A. Gómez-Tejedor is inadvertently missed from the author list. On page 1304, the author names should read M Lebourg1, S Martinez-Diaz2, N García-Giralt2, R Torres-Claramunt2, JA Gómez-Tejedor3, JL Gomez Ribelles1,3, G Vila-Canet4 a...
Source: Journal of Biomaterials Applications - December 21, 2014 Category: Materials Science Tags: Corrigendum Source Type: research

Porous ovalbumin scaffolds with tunable properties: A resource-efficient biodegradable material for tissue engineering applications
In this study, highly porous three-dimensional scaffolds were fabricated by using three different crosslinkers: glutaraldehyde, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and 1,4-butanediol diglycidyl ether. Results showed that the overall scaffold properties such as morphology, pore size and mechanical properties could be modulated based on the type and concentration of crosslinkers used during the fabrication process. Subsequently, the efficacy of the different scaffolds for supporting cell proliferation was investigated. In vitro degradation was also carried on for the best scaffold based on the mechanical and cellu...
Source: Journal of Biomaterials Applications - December 21, 2014 Category: Materials Science Authors: Luo, B., Choong, C. Tags: Soft Tissues and Materials Source Type: research

Hybrid vitronectin-mimicking polycaprolactone scaffolds for human retinal progenitor cell differentiation and transplantation
Many advances have been made in an attempt to treat retinal degenerative diseases, such as age-related macular degeneration and retinitis pigmentosa. The irreversible loss of photoreceptors is common to both, and currently no restorative clinical treatment exists. It has been shown that retinal progenitor and photoreceptor precursor cell transplantation can rescue the retinal structure and function. Importantly, retinal progenitor cells can be collected from the developing neural retina with further expansion and additional modification in vitro, and the delivery into the degenerative host can be performed as a single...
Source: Journal of Biomaterials Applications - December 21, 2014 Category: Materials Science Authors: Lawley, E., Baranov, P., Young, M. Tags: Soft Tissues and Materials Source Type: research

In vitro and in vivo evaluation of a novel collagen/cellulose nanocrystals scaffold for achieving the sustained release of basic fibroblast growth factor
This study demonstrated that collagen/CNCs/bFGF-GMs scaffolds have great potential in skin tissue engineering. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - December 21, 2014 Category: Materials Science Authors: Li, W., Lan, Y., Guo, R., Zhang, Y., Xue, W., Zhang, Y. Tags: Soft Tissues and Materials Source Type: research

Synthesis and self-assembly of amphiphilic poly(acrylicacid)-poly({varepsilon}-caprolactone)-poly(acrylicacid) block copolymer as novel carrier for 7-ethyl-10-hydroxy camptothecin
This study aimed to develop a novel self-assembled polymeric micelles for targeted delivery in tumor cells in order to overcome not only various drawbacks of 7-ethyl-10-hydroxy camptothecin (SN-38) but also various reported limitations of other drug delivery systems, especially low drug loading and premature release. Custom synthesized amphiphilic triblock copolymer poly(acrylic acid)–poly(-caprolactone)–poly(acrylic acid) (PAA13–PCL35–PAA13) was used to prepare kinetically stable micelles by nanoprecipitation and modified nanoprecipitation procedure. Core-shell micelles with diameter of 120–1...
Source: Journal of Biomaterials Applications - December 21, 2014 Category: Materials Science Authors: Djurdjic, B., Dimchevska, S., Geskovski, N., Petrusevska, M., Gancheva, V., Georgiev, G., Petrov, P., Goracinova, K. Tags: Nanotechnology in Biomaterials Source Type: research

Odontogenic stimulation of human dental pulp cells with bioactive nanocomposite fiber
The aim of the present study was to investigate the effects of a composite nanofibrous matrix made of biopolymer blend polycaprolactone-gelatin (BP) and mesoporous bioactive glass nanoparticles (BGNs) on the odontogenic differentiation of human dental pulp cells (HDPCs). BGN-BP nanomatrices, with BGN content of up to 20 wt%, were produced via electrospinning. The differentiation of the HDPCs was evaluated by using an ALP activity assay, calcified nodule formation, and mRNA expression for markers. Integrin and its underlying signal pathways were assessed via reverse transcriptase-polymerase chain reaction and Western blot a...
Source: Journal of Biomaterials Applications - December 21, 2014 Category: Materials Science Authors: Kim, G.-H., Park, Y.-D., Lee, S.-Y., El-Fiqi, A., Kim, J.-J., Lee, E.-J., Kim, H.-W., Kim, E.-C. Tags: Nanotechnology in Biomaterials Source Type: research

Effects of fiber density and plasma modification of nanofibrous membranes on the adhesion and growth of HaCaT keratinocytes
It may be possible to regulate the cell colonization of biodegradable polymer nanofibrous membranes by plasma treatment and by the density of the fibers. To test this hypothesis, nanofibrous membranes of different fiber densities were treated by oxygen plasma with a range of plasma power and exposure times. Scanning electron microscopy and mechanical tests showed significant modification of nanofibers after plasma treatment. The intensity of the fiber modification increased with plasma power and exposure time. The exposure time seemed to have a stronger effect on modifying the fiber. The mechanical behavior of the membrane...
Source: Journal of Biomaterials Applications - December 21, 2014 Category: Materials Science Authors: Bacakova, M., Lopot, F., Hadraba, D., Varga, M., Zaloudkova, M., Stranska, D., Suchy, T., Bacakova, L. Tags: Nanotechnology in Biomaterials Source Type: research

Chondrogenic potential of human articular chondrocytes and skeletal stem cells: A comparative study
This study has examined the chondrogenic potential of human STRO-1-immunoselected SSCs (STRO-1+ SSCs), in comparison to human articular chondrocytes (HACs), by utilising two bioengineering strategies, namely "scaffold-free" three-dimensional (3-D) pellet culture and culture using commercially available, highly porous, 3-D scaffolds with interconnected pore networks. STRO-1+ SSCs were isolated by magnetic-activated cell sorting from bone marrow samples of haematologically normal osteoarthritic individuals following routine hip replacement procedures. Chondrocytes were isolated by sequential enzymatic digestion of deep zone ...
Source: Journal of Biomaterials Applications - December 21, 2014 Category: Materials Science Authors: Li, S., Sengers, B. G., Oreffo, R. O., Tare, R. S. Tags: Hard Tissues and Materials Source Type: research

Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets
Ceramic/metal composites, cermets, arise from the idea to combine the dissimilar properties in the pure materials. This work aims to study the biocompatibility of new micro-nanostructured 3 Y-TZP/Ti materials with 25, 50 and 75 vol.% Ti, which have been successfully obtained by spark slasma sintering technology, as well as to correlate their surface properties (roughness, wettability and chemical composition) with the osteoblastic cell response. All samples had isotropic and slightly waved microstructure, with sub-micrometric average roughness. Composites with 75 vol.% Ti had the highest surface hydrophilicity. Surface che...
Source: Journal of Biomaterials Applications - December 21, 2014 Category: Materials Science Authors: Fernandez-Garcia, E., Guillem-Marti, J., Gutierrez-Gonzalez, C. F., Fernandez, A., Ginebra, M.-P., Lopez-Esteban, S. Tags: Hard Tissues and Materials Source Type: research