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Investigation of the in vitro photocatalytic antibacterial activity of nanocrystalline TiO2 and coupled TiO2/Ag containing copolymer on the surface of medical grade titanium
Antibacterial surfaces have been in the focus of research for years, driven by an unmet clinical need to manage an increasing incidence of implant-associated infections. The use of silver has become a topic of interest because of its proven broad-spectrum antibacterial activity and track record as a coating agent of soft tissue implants and catheters. However, for the time being, the translation of these technological achievements for the improvement of the antibacterial property of hard tissue titanium (Ti) implants remains unsolved. In our study, we focused on the investigation of the photocatalysis mediated antibacteria...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Györgyey, A., Janovak, L., Adam, A., Kopniczky, J., Toth, K. L., Deak, A., Panayotov, I., Cuisinier, F., Dekany, I., Turzo, K. Tags: Functional Biomaterials Surfaces Source Type: research

In vivo quantification of gentamicin released from an implant coating
Drug-releasing implants are gaining increasing interest. The present study reports a detailed physicochemical analysis of a polymeric coating based on poly(D,L-lactide) and the incorporated gentamicin combined with an in vitro and in vivo study of the gentamicin release. Differential scanning calorimeter, Fourier transform infrared spectroscopy, gel permeation chromatography and high-performance liquid chromatography showed no effect of the gamma sterilisation on the coating components or an interaction of the polymer and the gentamicin. Microbiological analysis revealed an inhibition of bacterial growth on the i...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Nast, S., Fassbender, M., Bormann, N., Beck, S., Montali, A., Lucke, M., Schmidmaier, G., Wildemann, B. Tags: Functional Biomaterials Surfaces Source Type: research

Prednisolone- and sirolimus-eluting stent: Anti-inflammatory approach for inhibiting in-stent restenosis
Glucocorticoids are powerful anti-inflammatory, immunosuppressive, and anti-proliferative agents. The aim of this study was to evaluate the effectiveness of a prednisolone- (PDScs) and sirolimus-coated stent (SRLcs) in preventing artery vessel neointimal hyperplasia and inflammatory reactions in vitro and in vivo. PDS, a synthetic glucocorticoid, is a derivative of cortisol, which is used to treat a variety of inflammatory and autoimmune conditions. The stents were fabricated with PDS, SRL, or both agents using a layer-by-layer coating system (designated as PDScs, SRLcs, and PDSRLcs, respectively). The surface mo...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Lee, S.-Y., Bae, I.-H., Sung Park, D., Jang, E.-J., Shim, J.-W., Lim, K.-S., Park, J.-K., Sim, D. S., Jeong, M. H. Tags: Functional Biomaterials Surfaces Source Type: research

pH-triggered sustained release of arsenic trioxide by polyacrylic acid capped mesoporous silica nanoparticles for solid tumor treatment in vitro and in vivo
In this study, a polyacrylic acid capped pH-triggered mesoporous silica nanoparticles was conducted to improve the pharmacokinetics and enhance the antitumor effect of arsenic trioxide. The mesoporous silica nanoparticles loaded with arsenic trioxide was grafted with polyacrylic acid (PAA-ATO-MSN) as a pH-responsive biomaterial on the surface to achieve the release of drug in acidic microenvironment of tumor, instead of burst release action in circulation. The nanoparticles were characterized with uniform grain size (particle sizes of 158.6 ± 1.3 nm and pore sizes of 3.71 nm, respectively), historically comparable d...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Xiao, X., Liu, Y., Guo, M., Fei, W., Zheng, H., Zhang, R., Zhang, Y., Wei, Y., Zheng, G., Li, F. Tags: Nanotechnology in Biomaterials Source Type: research

Nanoparticles based on phenylalanine ethyl ester-alginate conjugate as vitamin B2 delivery system
Phenylalanine ethyl ester (PAE)–alginate (Alg) conjugate (PAE–Alg, PEA) was synthesized and formation of an amide bond between PAE and Alg was confirmed by Fourier transformed-infrared and 1H nuclear magnetic resonance spectroscopy. The degree of PAE substitution was 3.5–4.7 (PAE group per hundred sugar residues of Alg) which was determined by elemental analysis. The critical aggregation concentration values determined for PEA conjugates PEA1, PEA2, and PEA3 were 0.20, 0.12, and 0.10 mg/ml, respectively. The particle size of PEA nanoparticles (PEA-NPs) decreased from 425 nm to 226 nm with the increasing d...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Zhang, P., Zhao, S.-R., Li, J.-X., Hong, L., Raja, M. A., Yu, L.-J., Liu, C.-G. Tags: Nanotechnology in Biomaterials Source Type: research

Effective method of chitosan-coated alginate nanoparticles for target drug delivery applications
In the present study, alginate nanoparticles were firstly prepared for paclitaxel (PTX) delivery with an average size of 200 ± 21 nm. To improve the stability and targeting effect, the chitosan (CS) and folate-chitosan (FA-CS) were introduced to form PTX-loaded CS/ALG NPs and FA-CS/ALG NPs by a new double emulsion cross-linking electrostatic attraction method. The optimization chitosan concentration was 0.5% obtained from the experiment results. The CS/ALG-PTX NPs and FA-CS/ALG-PTX NPs had the average particle size of 306.9 ± 12.9 nm and 283.6 ± 19.2 nm with the zeta potential of 31.1 ± 1.3 mV a...
Source: Journal of Biomaterials Applications - June 20, 2016 Category: Materials Science Authors: Wang, F., Yang, S., Yuan, J., Gao, Q., Huang, C. Tags: Nanotechnology in Biomaterials Source Type: research

Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis
In this study, by combining the advantages of drug treatment with a physical barrier, an ibuprofen-conjugated crosslinkable polygalacturonic acid and hyaluronic acid hydrogel was developed for epidural fibrosis prevention. Conjugation was confirmed and measured by 1D 1H NMR spectroscopy. In vitro analysis showed that the ibuprofen-conjugated polygalacturonic acid–hyaluronic acid hydrogel showed low cytotoxicity. In addition, the conjugated ibuprofen decreased prostaglandin E2 production of the lipopolysaccharide-induced RAW264.7 cells. Histological data in in vivo studies indicated that the scar tissue adhe...
Source: Journal of Biomaterials Applications - April 17, 2016 Category: Materials Science Authors: Lin, C.-Y., Peng, H.-H., Chen, M.-H., Sun, J.-S., Chang, C.-J., Liu, T.-Y., Chen, M.-H. Tags: Soft Tissues and Materials Source Type: research

Biodegradable scaffolds designed to mimic fascia-like properties for the treatment of pelvic organ prolapse and stress urinary incontinence
In conclusion, the electrospinning technique can be easily modified to develop biodegradable scaffolds with a spectrum of mechanical properties allowing extracellular matrix organisation towards human-like fascia. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - April 17, 2016 Category: Materials Science Authors: Roman, S., Mangir, N., Bissoli, J., Chapple, C. R., MacNeil, S. Tags: Soft Tissues and Materials Source Type: research

In vitro and in vivo osteogenic activity of the novel vancomycin-loaded bone-like hydroxyapatite/poly(amino acid) scaffold
Conclusion Vancomycin-loaded bone-like hydroxyapatite/poly(amino acid) scaffold has good potential for the repair of infectious bone defects because of its ability to deliver antibiotics and promote bone regeneration. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - April 17, 2016 Category: Materials Science Authors: Cao, Z., Jiang, D., Yan, L., Wu, J. Tags: Hard Tissues and Materials Source Type: research

Composite poly(L-lactic-acid)/silk fibroin scaffold prepared by electrospinning promotes chondrogenesis for cartilage tissue engineering
Nanofibrous materials produced by electrospinning have attracted considerable attention from researchers in regenerative medicine. A combination of nanofibrous scaffold and chondrocytes is considered promising for repair of cartilage defect or damage. In the present study, we fabricated a poly(l-lactic-acid) (PLLA)/silk fibroin (SF) nanofibrous scaffold by electrospinning and evaluated its chondrogenic potential. The PLLA/SF nanofibers were characterized for diameter, surface wettability, swelling ratio, and tensile strength. Through in vitro experiments, PLLA/SF scaffold–chondrocyte interactions were investigated re...
Source: Journal of Biomaterials Applications - April 17, 2016 Category: Materials Science Authors: Li, Z., Liu, P., Yang, T., Sun, Y., You, Q., Li, J., Wang, Z., Han, B. Tags: Hard Tissues and Materials Source Type: research

The effect of fiber size and pore size on cell proliferation and infiltration in PLLA scaffolds on bone tissue engineering
The scaffold microstructure has a great impact on cell functions in tissue engineering. Herein, the PLLA scaffolds with hierarchical fiber size and pore size were successfully fabricated by thermal-induced phase separation or combined thermal-induced phase separation and salt leaching methods. The PLLA scaffolds were fabricated as microfibrous scaffolds, microfibrous scaffolds with macropores (50–350 µm), nanofibrous scaffolds with micropores (100 nm to 10 µm), and nanofibrous scaffolds with both macropores and micropores by tailoring selective solvents for forming different fiber size and pre-sieved salt...
Source: Journal of Biomaterials Applications - April 17, 2016 Category: Materials Science Authors: Wang, X., Lou, T., Zhao, W., Song, G., Li, C., Cui, G. Tags: Hard Tissues and Materials Source Type: research

Antibiotic-eluting hydrophilized PMMA bone cement with prolonged bactericidal effect for the treatment of osteomyelitis
In this study, hydrophilized poly(methyl methacrylate) (PMMA) bone cements containing Pluronic F68 (EG79PG28EG79) as a hydrophilic additive and vancomycin (F68-VA cements) were prepared to allow the sustained release of the antibiotic for adequate periods of time without any significant loss of mechanical properties. The compressive strengths of the bone cements with Pluronic F68 compositions less than 7 wt% were not significantly different compared with the control vancomycin-loaded bone cement (VA cement). The F68 (7 wt%)-VA cement showed sustained release of the antibiotic for up to 11 weeks and almost 100% release from...
Source: Journal of Biomaterials Applications - April 17, 2016 Category: Materials Science Authors: Oh, E. J., Oh, S. H., Lee, I. S., Kwon, O. S., Lee, J. H. Tags: Hard Tissues and Materials Source Type: research

The influence of metal-based biomaterials functionalized with sphingosine-1-phosphate on the cellular response and osteogenic differentaion potenial of human adipose derived mesenchymal stem cells in vitro
This study investigated the effect of TiO2, doped with S1P in two different dosages on cellular response as well as osteogenic differentiation potential of human adipose derived multipotent stromal stem cells (hASC). The authors have shown that S1P mediates hASCs morphology, proliferation activity and population doubling time in a dose-dependent manner. They have also demonstrated that functionalization of TiO2 coating with a higher dosage of S1P, i.e. 80 ng/ml [(TiO2/S1P(CII)] activated both S1PR type 1 and type 2 on mRNA level. The results indicated an increase in secretion of BMP-2, Osteopontin and Osteocalcin by osteob...
Source: Journal of Biomaterials Applications - April 17, 2016 Category: Materials Science Authors: Marycz, K., Krzak, J., Maredziak, M., Tomaszewski, K. A., Szczurek, A., Moszak, K. Tags: Review Paper Source Type: research

Mechanistic contribution of electroconductive hydroxyapatite-titanium disilicide composite on the alignment and proliferation of cells
This study underscores the effectiveness of HA–TiSi2 in favorably modulating the cellular activity, myoblast in particular. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - April 17, 2016 Category: Materials Science Authors: Kumar, A., Nune, K., Basu, B., Misra, R. Tags: Functional Biomaterials Surfaces Source Type: research

Effects of surface functional groups on proliferation and biofunction of Schwann cells
In this study, we investigated cell adhesion, survival, proliferation, and neurotrophic actions of Schwann cells cultured on glass coverslips modified with different chemical groups, including methyl, carboxyl, amino, hydroxyl, mercapto, and sulfonic groups. Schwann cells on amino and carboxyl surfaces had higher attachment rate, presenting good morphology, high proliferation, and strong neurotrophic functions, while on methyl surfaces, few cells can survive, cells shrunk into round shape, exhibiting poor proliferation and weak neurotrophic functions. Growth of cells on other groups was between methyl and amino, carboxyl, ...
Source: Journal of Biomaterials Applications - April 17, 2016 Category: Materials Science Authors: Wang, Y., Ji, Y., Zhao, Y., Kong, Y., Gao, M., Feng, Q., Wu, Y., Yang, Y. Tags: Functional Biomaterials Surfaces Source Type: research