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Nanoassemblies constructed from bimodal mesoporous silica nanoparticles and surface-coated multilayer pH-responsive polymer for controlled delivery of ibuprofen
The pH-sensitive poly(D-A) grafted amine-functionalized bimodal mesoporous silica (D-A/BMMs) was prepared by a facile method used as a drug delivery vehicle. They exhibited superior properties such as good dispersion in aqueous medium, high drug loading efficiency, improved stability and high drug release rates. Meanwhile, its structural features and performances in a controlled delivery of ibuprofen (IBU) were systematically investigated by using XRD, N2 adsorption and desorption, SEM, TEM, FT-IR, elemental analysis and TG techniques. The results demonstrated that the obtained nanocomposite presented a flexible control ov...
Source: Journal of Biomaterials Applications - August 12, 2016 Category: Materials Science Authors: Guo, Y., Sun, J., Bai, S., Jin, X. Tags: Nanotechnology in Biomaterials Source Type: research

Multifunctional upconversion nanoparticles for targeted dual-modal imaging in rat glioma xenograft
Conclusions Targeted UCL and magnetic resonance imaging dual-modal in vivo imaging using Yb3+/Er3+/Li+ codoped NaGdF4 core-shell nanostructure can serve as a platform technology for the next generation of intraoperative probes for image-guided tumor resection. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - August 12, 2016 Category: Materials Science Authors: Yang, L., Shao, B., Zhang, X., Cheng, Q., Lin, T., Liu, E. Tags: Nanotechnology in Biomaterials Source Type: research

Mechanical properties, biological behaviour and drug release capability of nano TiO2-HAp-Alginate composite scaffolds for potential application as bone implant material
Nanocomposite scaffolds of TiO2 and hydroxyapatite nanoparticles with alginate as the binding agent were fabricated using the freeze drying technique. TiO2, hydroxyapatite and alginate were used in the ratio of 1:1:4. The scaffolds were characterized using X-ray diffraction, fourier transform infrared spectroscopy, and scanning electron microscopy. The biocompatibility of the scaffolds was evaluated using cell adhesion and MTT assay on osteosarcoma (MG-63) cells. Scanning electron microscopy analysis revealed that cells adhered to the surface of the scaffolds with good spreading. The mechanical properties of the scaffolds ...
Source: Journal of Biomaterials Applications - August 12, 2016 Category: Materials Science Authors: Naik, K., Chandran, V. G., Rajashekaran, R., Waigaonkar, S., Kowshik, M. Tags: Nanotechnology in Biomaterials Source Type: research

Chitosan-functionalised single-walled carbon nanotube-mediated drug delivery of SNX-2112 in cancer cells
This study aimed to build a new type of drug delivery system using single-walled carbon nanotubes (SWNTs) for controllable release of SNX-2112; chitosan (CHI) was non-covalently added to SWNTs to improve their biocompatibility. SWNTs-CHI demonstrated high drug-loading capability; the release of SNX-2112 was pH triggered and time related. The intracellular reactive oxygen species of SWNTs–CHI increased, compared with that of SWNTs, leading to higher mitogen-activated protein kinase and cell apoptosis. The results of western-blotting, lactate dehydrogenase (LDH) release assay, and cell viability assay analyses indicate...
Source: Journal of Biomaterials Applications - August 12, 2016 Category: Materials Science Authors: Zheng, L., Wu, S., Tan, L., Tan, H., Yu, B. Tags: Nanotechnology in Biomaterials Source Type: research

Potent antimicrobial and antibiofilm activities of bacteriogenically synthesized gold-silver nanoparticles against pathogenic bacteria and their physiochemical characterizations
The objective of this study was to develop a bimetallic nanoparticle with enhanced antibacterial activity that would improve the therapeutic efficacy against bacterial biofilms. Bimetallic gold–silver nanoparticles were bacteriogenically synthesized using -proteobacterium, Shewanella oneidensis MR-1. The antibacterial activities of gold–silver nanoparticles were assessed on the planktonic and biofilm phases of individual and mixed multi-cultures of pathogenic Gram negative (Escherichia coli and Pseudomonas aeruginosa) and Gram positive bacteria (Enterococcus faecalis and Staphylococcus aureus), respectively. Th...
Source: Journal of Biomaterials Applications - August 12, 2016 Category: Materials Science Authors: Ramasamy, M., Lee, J.-H., Lee, J. Tags: Nanotechnology in Biomaterials Source Type: research

Elution profiles of tobramycin and vancomycin from high-purity calcium sulphate beads incubated in a range of simulated body fluids
The aim of this study was to characterise the elution profiles of antibiotics in combination with pharmaceutical grade calcium sulphate beads in phosphate buffered saline and other physiological solutions which more closely mimic the in vivo environment. Synthetic recrystallised calcium sulphate was combined with vancomycin hydrochloride powder and tobramycin sulphate solution and the paste was formed into 3 mm diameter hemispherical beads. Then 2 g of beads were immersed in 2 ml of either phosphate buffered saline, Dulbecco’s Modified Eagle Medium or Hartmann’s solution and incubated at 37℃ for up ...
Source: Journal of Biomaterials Applications - August 12, 2016 Category: Materials Science Authors: Cooper, J., Florance, H., McKinnon, J., Laycock, P., Aiken, S. Tags: Hard Tissues and Materials Source Type: research

Bone cement with a modified polyphosphate network structure stimulates hard tissue regeneration
In this study, a calcium polyphosphate cement (CpPC) consisting of basic components was investigated to assess its potential for hard tissue regeneration. The added basic components for improving the structural stability, which controlled the setting time, where the setting reaction resulted in the formation of amorphous structure with a re-constructed polyphosphate. Moreover, the characteristics were controlled by the composition, which determined the polyphosphate structure. CpPC exhibited outstanding dissolution rate compared with the common biodegradable cement, brushite cement (2.5 times). Despite high amounts of diss...
Source: Journal of Biomaterials Applications - August 12, 2016 Category: Materials Science Authors: Lee, B.-H., Hong, M.-H., Kim, M.-C., Kwon, J.-S., Ko, Y.-M., Choi, H.-J., Lee, Y.-K. Tags: Hard Tissues and Materials Source Type: research

Microsphere-based scaffolds encapsulating chondroitin sulfate or decellularized cartilage
Extracellular matrix materials such as decellularized cartilage (DCC) and chondroitin sulfate (CS) may be attractive chondrogenic materials for cartilage regeneration. The goal of the current study was to investigate the effects of encapsulation of DCC and CS in homogeneous microsphere-based scaffolds, and to test the hypothesis that encapsulation of these extracellular matrix materials would induce chondrogenesis of rat bone marrow stromal cells. Four different types of homogeneous scaffolds were fabricated from microspheres of poly(D,L-lactic-co-glycolic acid): Blank (poly(D,L-lactic-co-glycolic acid) only; negative cont...
Source: Journal of Biomaterials Applications - August 12, 2016 Category: Materials Science Authors: Gupta, V., Tenny, K. M., Barragan, M., Berkland, C. J., Detamore, M. S. Tags: Hard Tissues and Materials Source Type: research

In vitro proliferation and osteogenic differentiation of human dental pulp stem cells in injectable thermo-sensitive chitosan/{beta}-glycerophosphate/hydroxyapatite hydrogel
The objective of this study was to investigate the proliferation and osteogenic differentiation of dental pulp stem cells in injectable thermo-sensitive chitosan/β-glycerophosphate/hydroxyapatite hydrogel in vitro. The chitosan /β-glycerophosphate hydrogel and chitosan/β-glycerophosphate/hydroxyapatite hydrogel were prepared using the sol-gel method. The injectability of chitosan /β-glycerophosphate hydrogel and chitosan/β-glycerophosphate/hydroxyapatite hydrogel was measured using a commercial disposable syringe. Scanning electron microscopy was used to observe the inner structure of hydrogel...
Source: Journal of Biomaterials Applications - August 12, 2016 Category: Materials Science Authors: Chen, Y., Zhang, F., Fu, Q., Liu, Y., Wang, Z., Qi, N. Tags: Hard Tissues and Materials Source Type: research

Evaluation of polypropylene mesh coated with biological hydrogels for temporary closure of open abdomen
In conclusion, the modified temporary abdominal closure composite could significantly protect the intestines from mechanical damage and accelerate wound healing. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Deng, Y., Ren, J., Chen, G., Li, G., Guo, K., Hu, Q., Wu, X., Wang, G., Gu, G., Li, J. Tags: Soft Tissues and Materials Source Type: research

Collagen/gold nanoparticle nanocomposites: A potential skin wound healing biomaterial
In this study, nanocomposite collagen scaffolds incorporating gold nanoparticles (AuNPs) were prepared for wound healing applications. Initially, dose (<20 ppm) and size (>20 nm) of AuNPs that were not cytotoxic on HaCat keratinocytes and 3T3 fibroblasts were determined. Both collagen sponges and AuNP-incorporated nanocomposites (CS-Au) were cross-linked with glutaraldehyde (CS-X and CS-AuX). Incorporation of AuNPs into cross-linked scaffolds enhanced their stability against enzymatic degradation and increased the tensile strength. Hydrolytic degradation of CS-Au group was also less than CS after seven days. Upon con...
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Akturk, O., Kismet, K., Yasti, A. C., Kuru, S., Duymus, M. E., Kaya, F., Caydere, M., Hucumenoglu, S., Keskin, D. Tags: Soft Tissues and Materials Source Type: research

Dopamine-loaded liposome and its application in electrochemical DNA biosensor
In this study, disruption and lyophilization–rehydration of dopamine-loaded liposome and its application in electrochemical DNA biosensor was investigated. The liposomes containing soyphosphatidylcholine and cholesterol were prepared through thin-layer hydration. First, an investigation was carried out to find an appropriate lysing agent for disruption of prepared liposomes. Differential pulse voltammetry, as a high sensitive electrochemical technique, was used along with a multi-walled carbon nanotubes modified glassy carbon electrode for sensitive electrochemical detection of released dopamine from disrupted liposo...
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Mahmoudi-Badiki, T., Alipour, E., Hamishehkar, H., Golabi, S. M. Tags: Nanotechnology in Biomaterials Source Type: research

Daunomycin-loaded superparamagnetic iron oxide nanoparticles: Preparation, magnetic targeting, cell cytotoxicity, and protein delivery research
The clinical use of daunomycin is restricted by dose-dependent toxicity and low specificity against cancer cells. In the present study, modified superparamagnetic iron oxide nanoparticles were employed to load daunomycin and the drug-loaded nanospheres exhibited satisfactory size and smart pH-responsive release. The cellular uptake efficiency, targeted cell accumulation, and cell cytotoxicity experimental results proved that the superparamagnetic iron oxide nanoparticle-loading process brings high drug targeting without decreasing the cytotoxicity of daunomycin. Moreover, a new concern for the evaluation of nanophase drug ...
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Liu, M.-C., Jin, S.-f., Zheng, M., Wang, Y., Zhao, P.-l., Tang, D.-t., Chen, J., Lin, J.-q., Wang, X.-h., Zhao, P. Tags: Nanotechnology in Biomaterials Source Type: research

A therapeutic delivery system for chronic osteomyelitis via a multi-drug implant based on three-dimensional printing technology
Chronic osteomyelitis is difficult to be cured and often relapses, which presents to be a great challenge to clinicians. We conducted this original study to explore the efficiency of therapeutic alliance for chronic osteomyelitis by a multi-drug implant based on three-dimensional printing technology. We designed and fabricated preciously a multi-drug implant with a multi-layered concentric cylinder construction by three-dimensional (3D) printing technology. Levofloxacin and tobramycin were incorporated into the drug implant in a specific sequence. The drug release property of the drug implant was assayed in vitro. We ...
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Wu, W., Ye, C., Zheng, Q., Wu, G., Cheng, Z. Tags: Hard Tissues and Materials Source Type: research

A biodegradable antibiotic-eluting PLGA nanofiber-loaded deproteinized bone for treatment of infected rabbit bone defects
We fabricated a biodegradable antibiotic-eluting poly(d,l)-lactide-co-glycolide nanofiber-loaded deproteinized bone (ANDB) scaffold that provided sustained delivery of vancomycin to repair methicillin-resistant Staphylococcus aureus bone defects. To fabricate the biodegradable ANDB, poly(d,l)-lactide-co-glycolide and vancomycin were first dissolved in 1,1,1,3,3,3-hexafluoro-2-propano. The solution was then electrospun to produce biodegradable antibiotic-eluting membranes that were deposited on the surface of bovine deproteinized cancellous bone. We used scanning electron microscopy to determine the properties of the scaffo...
Source: Journal of Biomaterials Applications - August 3, 2016 Category: Materials Science Authors: Gao, J., Huang, G., Liu, G., Liu, Y., Chen, Q., Ren, L., Chen, C., Ding, Z. Tags: Hard Tissues and Materials Source Type: research