Journal of Biomaterials Applications This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Preparation and characterization of biocompatible and thermoresponsive micelles based on poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) grafted on polysuccinimide for drug delivery
In this study, the biocompatible temperature-sensitive micelles based on PSI-g-poly(NIPAAm-co-DMAAm) have great potential to act as a suitable carrier for drug delivery. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - August 18, 2014 Category: Materials Science Authors: Yeh, J.-C., Hsu, Y.-T., Su, C.-M., Wang, M.-C., Lee, T.-H., Lou, S.-L. Tags: Articles Source Type: research

Carboxymethylcellulose hydrogels support central nervous system-derived tumor-cell chemotactic migration: Comparison with conventional extracellular matrix macromolecules
The local microenvironment plays an important role in maintaining the dynamics of the extracellular matrix and the cell–extracellular matrix relationship. The extracellular matrix is a complex network of macromolecules with distinct mechanical and biochemical characteristics. Disruptions in extracellular matrix homeostasis are associated with the onset of cancer. The extracellular matrix becomes highly disorganized, and the cell–matrix relationship changes, resulting in altered cell-signaling processes and metastasis. Medulloblastoma is one of the most common malignant pediatric brain tumors in the United State...
Source: Journal of Biomaterials Applications - August 18, 2014 Category: Materials Science Authors: Singh, T., Kothapalli, C., Varma, D., Nicoll, S. B., Vazquez, M. Tags: Articles Source Type: research

Pretreatment-dependent surface chemistry of wood nanocellulose for pH-sensitive hydrogels
In this study, we demonstrate the production of nanocellulose with tailor-made surface chemistry, by pre-treating the raw cellulose fibres with carboxymethylation and periodate oxidation. The pre-treatments yielded a highly nanofibrillated material, with significant amounts of aldehyde and carboxyl groups. Importantly, the poly-anionic surface of the oxidized nanocellulose opens up for novel applications, i.e. micro-porous materials with pH-responsive characteristics. This is due to the swelling capacity of the 3D micro-porous structures, which have ionisable functional groups. In this study, we demonstrated that nanocellu...
Source: Journal of Biomaterials Applications - August 18, 2014 Category: Materials Science Authors: Chinga-Carrasco, G., Syverud, K. Tags: Articles Source Type: research

Electrospun soy protein nanofiber scaffolds for tissue regeneration
Electrospun fibers with an average fiber diameter in the nanometer range were prepared from soy protein isolate to develop scaffolds for tissue engineering applications. Poly(ethylene oxide) was added to facilitate fiber formation. The influence of processing parameters such as applied voltage, soy protein isolate and poly(ethylene oxide) concentrations, and poly(ethylene oxide) molecular weight on electrospun fiber morphology was investigated. Resulting soy protein isolate/poly(ethylene oxide) mats were carbodiimide crosslinked to increase construct robustness. Mechanical properties and in vitro biocompatibility of c...
Source: Journal of Biomaterials Applications - August 18, 2014 Category: Materials Science Authors: Ramji, K., Shah, R. N. Tags: Articles Source Type: research

Fiber-reinforced hydrogel scaffolds for heart valve tissue engineering
In this study, we integrated electrospun poly(glycerol sebacate) (PGS)–poly(-caprolactone) (PCL) microfiber scaffolds, which possess enhanced mechanical properties for heart valve engineering, within a hybrid hydrogel made from methacrylated hyaluronic acid and methacrylated gelatin. Sheep mitral valvular interstitial cells were encapsulated in the hydrogel and evaluated in hydrogel-only, PGS–PCL scaffold-only, and composite scaffold conditions. Although the cellular viability and metabolic activity were similar among all scaffold types, the presence of the hydrogel improved the three-dimensional distribution o...
Source: Journal of Biomaterials Applications - August 18, 2014 Category: Materials Science Authors: Eslami, M., Vrana, N. E., Zorlutuna, P., Sant, S., Jung, S., Masoumi, N., Khavari-Nejad, R. A., Javadi, G., Khademhosseini, A. Tags: Articles Source Type: research