Journal of Biomaterials Applications This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Biocompatibility assessment of spark plasma-sintered alumina-titanium cermets
Alumina-titanium materials (cermets) of enhanced mechanical properties have been lately developed. In this work, physical properties such as electrical conductivity and the crystalline phases in the bulk material are evaluated. As these new cermets manufactured by spark plasma sintering may have potential application for hard tissue replacements, their biocompatibility needs to be evaluated. Thus, this research aims to study the cytocompatibility of a novel alumina-titanium (25 vol. % Ti) cermet compared to its pure counterpart, the spark plasma sintered alumina. The influence of the particular surface properties (chemical...
Source: Journal of Biomaterials Applications - January 5, 2016 Category: Materials Science Authors: Guzman, R., Fernandez-Garcia, E., Gutierrez-Gonzalez, C. F., Fernandez, A., Lopez-Lacomba, J. L., Lopez-Esteban, S. Tags: Biomaterials Processing Source Type: research

Effect of l-lysine-assisted surface grafting for nano-hydroxyapatite on mechanical properties and in vitro bioactivity of poly(lactic acid-co-glycolic acid)
It is promising and challenging to study surface modification for nano-hydroxyapatite to improve the dispersion and enhance the mechanical properties and bioactivity of poly(lactic acid-co-glycolic acid). In this paper, we designed an effective new surface grafting with the assist of l-lysine for nano-hydroxyapatite, and the nano-hydroxyapatite surface grafted with the assist of l-lysine (g-nano-hydroxyapatite) was incorporated into poly(lactic acid-co-glycolic acid) to develop a series of g-nano-hydroxyapatite/poly(lactic acid-co-glycolic acid) nano-composites. The surface modification reaction for nano-hydroxyapatite, th...
Source: Journal of Biomaterials Applications - January 5, 2016 Category: Materials Science Authors: Liuyun, J., Lixin, J., Chengdong, X., Lijuan, X., Ye, L. Tags: Biomaterials Processing Source Type: research

Sol-gel processing of novel bioactive Mg-containing silicate scaffolds for alveolar bone regeneration
Periodontal tissue regeneration is an important application area of biomaterials, given the large proportion of the population affected by periodontal diseases like periodontitis. The aim of this study was the synthesis of a novel porous bioceramic scaffold in the SiO2–CaO–MgO system with specific properties targeted for alveolar bone tissue regeneration using a modification of the traditional foam replica technique. Since bioceramic scaffolds are considered brittle, scaffolds were also coated with gelatin in order to increase their mechanical stability. Gelatin was chosen for its biocompatibility, biodegradabi...
Source: Journal of Biomaterials Applications - January 5, 2016 Category: Materials Science Authors: Goudouri, O.-M., Vogel, C., Grünewald, A., Detsch, R., Kontonasaki, E., Boccaccini, A. R. Tags: Hard Tissues and Materials Source Type: research

Methotrexate-loaded glass ionomer cements for drug release in the skeleton: An examination of composition-property relationships
Chemotherapeutic-loaded bone cement may be an effective method of drug delivery for the management of cancer-related vertebral fractures that require cement injection for pain relief. Recent advancements in the development of aluminum-free glass ionomer cements (GICs) have rendered this class of biomaterials clinically viable for such applications. To expand the therapeutic benefits of these materials, this study examined, for the first time, their drug delivery potential. Through incrementally loading the GIC with methotrexate (MTX) by up to 10-wt%, composition–property relationships were established, correlating MT...
Source: Journal of Biomaterials Applications - January 5, 2016 Category: Materials Science Authors: Kiri, L., Filiaggi, M., Boyd, D. Tags: Hard Tissues and Materials Source Type: research

Comparison of human mesenchymal stem cells proliferation and differentiation on poly(methyl methacrylate) bone cements with and without mineralized collagen incorporation
Poly(methyl methacrylate) bone cement is widely used in vertebroplasty, joint replacement surgery, and other orthopaedic surgeries, while it also exposed many problems on mechanical property and biocompatibility. Better performance in mechanical match and bone integration is highly desirable. Recently, there reported that incorporation of mineralized collagen into poly(methyl methacrylate) showed positive results in mechanical property and osteointegration ability in vivo. In the present study, we focused on the comparison of osteogenic behavior between mineralized collagen incorporated in poly(methyl methacrylate) an...
Source: Journal of Biomaterials Applications - January 5, 2016 Category: Materials Science Authors: Wu, J., Xu, S., Qiu, Z., Liu, P., Liu, H., Yu, X., Cui, F.-Z., Chunhua, Z. R. Tags: Hard Tissues and Materials Source Type: research

Plasma-electrochemical deposition of porous zirconia on titanium-based dental material and in vitro interactions with primary osteoblasts cells
Three new porous zirconia-coated titanium materials using anodic plasma-electrochemical oxidation have been fabricated and characterized by scanning electron microscopy, electron probe microanalysis and X-ray diffraction. These ZrO2/TiO2 surfaces contained up to 43 wt% of ZrO2, 49 wt% TiO2 (M1–M3) and 8 wt% P2O5 (M2, M3). Zirconium titanate was detected as dominant microcrystalline phase. Primary human osteoblast cells were used for in vitro investigations. Cell proliferation and immunohistochemical analyses of morphology and expression of bone sialoprotein and osteocalcin were performed. Novel coatings M2 and M...
Source: Journal of Biomaterials Applications - January 5, 2016 Category: Materials Science Authors: Kaluđerovic, M. R., Schreckenbach, J. P., Graf, H.-L. Tags: Hard Tissues and Materials Source Type: research

Methacrylated gelatin and mature adipocytes are promising components for adipose tissue engineering
In this study, we evaluated the suitability of photo-crosslinkable methacrylated gelatin (GM) and mature adipocytes as components for the composition of three-dimensional fatty tissue constructs. Cytocompatibility evaluations of the GM and the photoinitiator Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) showed no cytotoxicity in the relevant range of concentrations. Matrix stiffness of cell-laden hydrogels was adjusted to native fatty tissue by tuning the degree of crosslinking and was shown to be comparable to that of native fatty tissue. Mature adipocytes were then cultured for 14 days within the GM resulting in...
Source: Journal of Biomaterials Applications - January 5, 2016 Category: Materials Science Authors: Huber, B., Borchers, K., Tovar, G. E., Kluger, P. J. Tags: Nanotechnology in Biomaterials Source Type: research

Evaluation of emulsion electrospun polycaprolactone/hyaluronan/epidermal growth factor nanofibrous scaffolds for wound healing
In this study, we fabricated biodegradable nanofibrous scaffolds with an emulsion electrospinning technique. The scaffolds were composed of polycaprolactone, hyaluronan and encapsulating epidermal growth factor. The morphology and core-sheath structure of the nanofibers were characterized by scanning electron microscopy and transmission electron microscopy. The scaffolds were also characterized for chemical composition and hydrophilicity with a Fourier-transform infrared analysis, energy dispersive spectroscopy and the water contact angle. An in vitro model protein bovine serum albumin and epidermal growth factor rele...
Source: Journal of Biomaterials Applications - January 5, 2016 Category: Materials Science Authors: Wang, Z., Qian, Y., Li, L., Pan, L., Njunge, L. W., Dong, L., Yang, L. Tags: Nanotechnology in Biomaterials Source Type: research

Analytical investigation of bilayer lipid biosensor based on graphene
Graphene is another allotrope of carbon with two-dimensional monolayer honeycomb. Owing to its special characteristics including electrical, physical and optical properties, graphene is known as a more suitable candidate compared to other materials to be used in the sensor application. It is possible, moreover, to use biosensor by using electrolyte-gated field effect transistor based on graphene (GFET) to identify the alterations in charged lipid membrane properties. The current article aims to show how thickness and charges of a membrane electric can result in a monolayer graphene-based GFET while the emphasis is on the c...
Source: Journal of Biomaterials Applications - January 5, 2016 Category: Materials Science Authors: Akbari, E., Buntat, Z., Shahraki, E., Parvaz, R., Kiani, M. J. Tags: Nanotechnology in Biomaterials Source Type: research

Thermosensitive tribrachia star-shaped s-P(NIPAM-co-DMAM) random copolymer micelle aggregates: Preparation, characterization, and drug release applications
Tribrachia star-shaped random copolymers with tunable thermosensitive phase transition temperature were designed and synthesized via a simple one-pot ammonolysis reaction approach with trimesic acid as cores. The self-assembly micellization behavior of the copolymers in aqueous solution was examined by surface tension, UV–vis transmittance, transmission electron microscope, and dynamic light scattering measurements, etc. The results indicated that the resultant copolymers formed thermosensitive micelle aggregates through hydrophobic interactions among the isopropyl groups of poly(N-isopropylacrylamide) PNIPAM chains ...
Source: Journal of Biomaterials Applications - January 5, 2016 Category: Materials Science Authors: Luo, Y.-L., Wang, Y., Wang, X., Xu, F., Chen, Y.-S. Tags: Nanotechnology in Biomaterials Source Type: research

Nanoparticle coating on the silane-modified surface of magnesium for local drug delivery and controlled corrosion
In this study, we proposed a potential method for the preparation of a magnesium-based medical device for local drug delivery and controlled corrosion. A magnesium surface was modified with 3-aminopropyltrimethoxy silane, and the resulting surface was then coated with drug-loaded nanoparticles made of poly (lactic-co-glycolic acid) via electrophoretic deposition. The drug-loaded nanoparticles (i.e., Tr_NP) exhibited a size of 250 ± 67 nm and a negative zeta potential of –20.9 ± 2.75 mV. The drug was released from the nanoparticles in a sustained manner for 21 days, and this did not change after their co...
Source: Journal of Biomaterials Applications - January 5, 2016 Category: Materials Science Authors: Lee, W. S., Park, M., Kim, M. H., Park, C. G., Huh, B. K., Seok, H. K., Choy, Y. B. Tags: Nanotechnology in Biomaterials Source Type: research

Treatment study of distal femur for parathyroid hormone (1-34) and {beta}-tricalcium phosphate on bone formation in critical size defects in rats
The objective of this study was to evaluate local bone formation following systemic administration of parathyroid hormone (1–34), a surgically implanted synthetic β-tricalcium phosphate bone biomaterial serving as a matrix to support new bone formation. Twelve weeks after bilateral ovariectomy, all rats underwent bone defect in the distal femurs, and β-tricalcium phosphate was implanted into critical sized defects. After defect operation, all animals were randomly divided into four groups and received following subcutaneous injections until death at four and eight weeks: sham rats (group ST); sham rats + pa...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Tao, Z.-S., Qiang, Z., Tu, K.-k., Huang, Z.-l., Xu, H.-m., Sun, T., Lv, Y.-X., Cui, W., Yang, L. Tags: Hard Tissues and Materials Source Type: research

In-vitro degradation characteristics of poly(e-caprolactone)/poly(glycolic acid) scaffolds fabricated via solid-state cryomilling
This study successfully brought forth the differences in resultant properties of the PCL/PGA scaffolds as a function of degradation time. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Jonnalagadda, J. B., Rivero, I. V., Warzywoda, J. Tags: Nanotechnology in Biomaterials Source Type: research

Evaluation of the biological tolerability of the starch-based medical device 4DryField(R) PH in vitro and in vivo a rat model
Conclusion 4DryField® PH is not cytotoxic and does not enhance viability of tumour cell lines. High dose of 4DryField® PH of 1.09 g/kg bodyweight is well tolerated and reduces weight loss in animals with peritoneal injury. The biocompatibility of 4DryField® PH can be rated as being excellent. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Poehnert, D., Abbas, M., Maegel, L., Sambale, F., Lavrentieva, A., Kreipe, H.-H., Klempnauer, J., Winny, M. Tags: Soft Tissues and Materials Source Type: research

Investigating the effect of silver coating on the solubility, antibacterial properties, and cytocompatibility of glass microspheres
In this study, glass microspheres (SiO2–Na2O–CaO–Al2O3) were synthesized and employed as substrates to investigate the effect Ag coating has on glass solubility and the subsequent biological effects. Initially, glasses were amorphous with a glass transition point (Tg) of 605℃ and microspheres were spherical with a mean particle diameter of 120 µm (±27). The Ag coating was determined to be crystalline in nature and its presence was confirmed using scanning electron microscopy and X-ray photoelectron spectroscopy. Ion release determined that Ag-coated (Ag-S) microspheres increased the Na...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Haas, L., Smith, C., Placek, L., Hall, M., Gong, Y., Mellott, N., Wren, A. W. Tags: Functional Biomaterials Surfaces Source Type: research