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Effect of low-temperature ethylene oxide and electron beam sterilization on the in vitro and in vivo function of reconstituted extracellular matrix-derived scaffolds
In conclusion, this study identifies two methods to terminally sterilize an ECM scaffold. In vitro scaffold properties were slightly changed without significantly influencing the biologic responses of the surrounding tissues in vivo. This is a critical step toward translating new tissue engineering strategies to clinical trials. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Proffen, B. L., Perrone, G. S., Fleming, B. C., Sieker, J. T., Kramer, J., Hawes, M. L., Murray, M. M. Tags: Article Source Type: research

Chitosan-glycolipid nanogels loaded with anti-obese marine carotenoid fucoxanthin: Acute and sub-acute toxicity evaluation in rodent model
In this study, nanoencapsulation is an approach adopted to improve bioavailability of FUCO by using ionic-gelation method with polymeric chitosan (CS) dispersed in glycolipid (GL), as a carrier. Further, the aim was to investigate adverse effect of acute and sub-acute toxicity of chitosan nanogels (CS-NGs) loaded with FUCO+GL in rats. In the acute toxicity study, FUCO was fed to rats at doses of 0.1, 1, 10 and 100 mg/kg body weight (BW). In the sub-acute toxicity study, FUCO was fed at doses of 1 and 10 mg/kg BW for 28 days. In both the studies, no mortality and abnormalities in gross morphology were observed. Acute toxici...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Ravi, H., Arunkumar, R., Baskaran, V. Tags: Soft Tissues and Materials Source Type: research

Characterization of antibacterial and adhesion properties of chitosan-modified glass ionomer cement
Conclusion Incorporation of acidic solutions of chitosan in the polyacrylic acid liquid of GIC at v/v ratios of 5–10% improved the antibacterial properties of conventional glass ionomer cement against S. mutans without adversely affecting its bonding to dentin surface. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Ibrahim, M. A., Neo, J., Esguerra, R. J., Fawzy, A. S. Tags: Original Article Source Type: research

Human aortic endothelial cell morphology influenced by topography of porous silicon substrates
Porous silicon has received much attention because of its optical properties and for its usefulness in cell-based biosensing, drug delivery, and tissue engineering applications. Surface properties of the biomaterial are associated with cell adhesion and with proliferation, migration, and differentiation. The present article analyzes the behavior of human aortic endothelial cells in macro- and nanoporous collagen-modified porous silicon samples. On both substrates, cells are well adhered and numerous. Confocal microscopy and scanning electron microscopy were employed to study the effects of porosity on the morphology of the...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Formentin, P., Catalan, U., Fernandez-Castillejo, S., Alba, M., Baranowska, M., Sola, R., Pallares, J., Marsal, L. F. Tags: Soft Tissues and Materials Source Type: research

Development of lattice-inserted 5-Fluorouracil-hydroxyapatite nanoparticles as a chemotherapeutic delivery system
Developing an effective vehicle for cancer treatment, hydroxyapatite nanoparticles were fabricated for drug delivery. When 5-Fluorouracil, a major chemoagent, is combined with hydroxyapatite nanocarriers by interclay insertion, the modified hydroxyapatite nanoparticles have superior lysosomal degradation profiles, which could be leveraged as controlled drug release. The decomposition of the hydroxyapatite nanocarriers facilitates the release of 5-Fluorouracil into the cytoplasm causing cell death. Hydroxyapatite nanoparticles with/without 5-Fluorouracil were synthesized and analyzed in this study. Their crystallization pro...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Tseng, C.-L., Chen, J.-C., Wu, Y.-C., Fang, H.-W., Lin, F.-H., Tang, T.-P. Tags: Nanotechnology in Biomaterials Source Type: research

Three-dimensional culture of mouse pancreatic islet on a liver-derived perfusion-decellularized bioscaffold for potential clinical application
This study advanced the field of regenerative medicine towards the development of a liver decellularized bioscaffold capable of forming a neo-organ and could be used as potential clinical application. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Xu, T., Zhu, M., Guo, Y., Wu, D., Huang, Y., Fan, X., Zhu, S., Lin, C., Li, X., Lu, J., Zhu, H., Zhou, P., Lu, Y., Wang, Z. Tags: Hard Tissues and Materials Source Type: research

Synthesis of efficient gene delivery systems by grafting pegylated alkylcarboxylate chains to PAMAM dendrimers: Evaluation of transfection efficiency and cytotoxicity in cancerous and mesenchymal stem cells
This study proved the potential utility of alkylcarboxylate-grafted PAMAM dendrimers (G4 and G5) with or without PEG modification for efficient gene transfer into cancerous cells as well as MSCs. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Ayatollahi, S., Hashemi, M., Kazemi Oskuee, R., Salmasi, Z., Mokhtarzadeh, A., Alibolandi, M., Abnous, K., Ramezani, M. Tags: Original Articles Source Type: research

Chitosan crosslinked microparticles with encapsulated polyphenols: Water sorption and release properties
Chitosan–glutaraldehyde microparticles were produced by emulsion crosslinking method to be used as drug delivery system for polyphenols from Thymus serpyllum L. aqueous extract. The effect of preparation conditions, chitosan concentration (1.5–3% w/v), and glutaraldehyde/chitosan (GA/Ch) mass ratio (0.15–1.20) on water and polyphenols transport properties was investigated. Swelling ratio of dry particles (68–230 µm) in water ranged from 280% to 530%, depending on the formulation. The decrease in swelling was observed with increased GA/Ch mass ratio (i.e. crosslinking degree) at the same chitos...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Trifkovic, K., Milasinovic, N., Djordjevic, V., Zdunic, G., Kalagasidis Krusic, M., Knezevic-Jugovic, Z., Savikin, K., Nedovic, V., Bugarski, B. Tags: Original Articles Source Type: research

APTES-modified nanosilica -- but neither APTES nor nanosilica -- inhibits endothelial cell growth via arrest of cell cycle at G1 phase
The adverse effects of nanomaterials on the living system have attracted considerable attention in the past few years. Such effects may come from either the core nanomaterials or the chemical agents used to modify the nanomaterials – the latter being largely overlooked. In a free form, these modifying agents might have little impact on living cells; however, they may exhibit distinct biological effects when they assemble into a larger dimension. Here, we report that (3-aminopropyl)triethoxysilane – a small molecule compound ubiquitously employed to functionalise nanosilica surface – could decrease the via...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Niu, Y., Chan, W.-I., Yu, N., Gan, J., Dong, L., Wang, C. Tags: Original Articles Source Type: research

Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue
Engineered anisotropic tissue constructs containing aligned cell and extracellular matrix structures are useful as in vitro models and for regenerative medicine. They are of particular interest for nervous system modelling and regeneration, where tracts of aligned neurons and glia are required. The self-alignment of cells and matrix due to tension within tethered collagen gels is a useful tool for generating anisotropic tissues, but requires an optimal balance between cell density, matrix concentration and time to be achieved for each specific cell type. The aim of this study was to develop an assay system based on co...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: ORourke, C., Drake, R. A., Cameron, G. W., Jane Loughlin, A., Phillips, J. B. Tags: Original Articles Source Type: research

Liquid transmission characteristics of padding bandages under pressure
This study investigates the in-plane fluid transport characteristics of needle-punched nonwoven padding bandages. It first reviewed the existing studies related to the problems, and discussed their limits and possible improvements in dealing with complex fluid transport issues in textile porous media. The measurement of fluid transport under different pressure levels was then done using a newly designed apparatus capable of simultaneously tracing the liquid in-plane spreading along different directions, and obtaining several transport characteristics of a testing sample, e.g. the liquid flow anisotropy, the rate of movemen...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Kumar, B., Das, A., Pan, N., Alagirusamy, R., Gupta, R., Singh, J. Tags: Soft Tissues and Materials Source Type: research

Sirolimus-eluting dextran and polyglutamic acid hybrid coatings on AZ31 for stent applications
Conclusion Results demonstrated that such a three-layer hybrid coating may be useful to improve the vascular biocompatibility of Mg stent materials. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Ma, J., Zhao, N., Zhu, D. Tags: Original Article Source Type: research

Constitution and in vivo test of micro-porous tubular scaffold for esophageal tissue engineering
Current clinical techniques in treating long-gap esophageal defects often lead to complications and high morbidity. Aiming at long-gap synthetic esophageal substitute, we had synthesized a biodegradable copolymer, poly(L-lactide-co-caprolactone) (PLLC), with low glass transition temperature. In this work, we developed a tubular PLLC porous scaffold using a self-designed tubular mold and thermal induced phase separation (TIPS) method. In order to enhance the interaction between tissue and scaffold, fibrin, a natural fibrous protein derived from blood fibrinogen, was coated on the scaffold circumferential surface. The fibrin...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Hou, L., Jin, J., Lv, J., Chen, L., Zhu, Y., Liu, X. Tags: Soft Tissues and Materials Source Type: research

Effects of the orientation of anti-BMP2 monoclonal antibody immobilized on scaffold in antibody-mediated osseous regeneration
We examined whether antibodies bound to a scaffold by passive adsorption versus through Protein G as a linker will exhibit differences in mediating bone formation. In vitro anti-BMP-2 monoclonal antibodies was immobilized on absorbable collagen sponge (ACS) with Protein G as a linker to bind the antibody through its Fc region and implanted into rat calvarial defects. The biomechanical strength of bone regenerated by absorbable collagen sponge/Protein G/anti-BMP-2 monoclonal antibodies immune complex was compared to ACS/anti-BMP-2 monoclonal antibodies or ACS/Protein G/isotype mAb control group. Results demonstrated hi...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Ansari, S., Freire, M., Choi, M. G., Tavari, A., Almohaimeed, M., Moshaverinia, A., Zadeh, H. H. Tags: Original Articles Source Type: research

Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications
Gold nanomaterials possess unique physical and chemical properties, which attracted much attention in recent years. As a new type of gold nanomaterials, gold nanostars (GNSTs) have been prepared and characterized in this study. GNSTs under near-infrared (NIR) light irradiation can exert not only cancer photothermal therapy via heat production but also photodynamic therapy via generation of reactive oxygen species. GNSTs were able to enter the cytoplasm as well as nuclei of human breast michigan cancer foundation-7 (MCF-7) cells. Under NIR light irradiation, GNSTs caused more severe DNA damage, arrest the cell cycle in G0/G...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Wang, L., Meng, D., Hao, Y., Zhao, Y., Li, D., Zhang, B., Zhang, Y., Zhang, Z. Tags: Original Articles Source Type: research