Effect of low-temperature ethylene oxide and electron beam sterilization on the in vitro and in vivo function of reconstituted extracellular matrix-derived scaffolds

In conclusion, this study identifies two methods to terminally sterilize an ECM scaffold. In vitro scaffold properties were slightly changed without significantly influencing the biologic responses of the surrounding tissues in vivo. This is a critical step toward translating new tissue engineering strategies to clinical trials.

Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Proffen, B. L., Perrone, G. S., Fleming, B. C., Sieker, J. T., Kramer, J., Hawes, M. L., Murray, M. M. Tags: Article Source Type: research