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Effect of biphasic calcium phosphate scaffold porosities on odontogenic differentiation of human dental pulp cells
In this study, biphasic calcium phosphate (BCP) scaffolds of 20/80 hydroxyapatite to beta tricalcium phosphate ratio with a mean pore size of 300 μm were prepared into BCP1, BCP2, BCP3, and BCP4 of 25%, 50%, 65%, and 75% of total porosities, respectively. The extracts of these scaffolds were assessed with regard to cell viability, proliferation, and differentiation of human dental pulp cells. The high alkalinity, and more calcium and phosphate ions release that were exhibited by BCP3 and BCP4 decreased the viability and proliferation of human dental pulp cells as compared to BCP1 and BCP2. BCP2 significantly increased b...
Source: Journal of Biomaterials Applications - March 23, 2016 Category: Materials Science Authors: AbdulQader, S. T., Rahman, I. A., Thirumulu, K. P., Ismail, H., Mahmood, Z. Tags: Hard Tissues and Materials Source Type: research

Test in canine extraction site preservations by using mineralized collagen plug with or without membrane
The aim of this study was to discuss the feasibility of porous mineralized collagen plug and bilayer mineralized collagen-guided bone regeneration membrane in site preservation in extraction sockets. The third mandibular premolars on both sides were extracted from four dogs, thus there were 16 alveolar sockets in all dogs and were randomly assigned into three groups. Group A had six alveolar sockets, and groups B and C had five alveolar sockets, respectively. Each alveolar socket of group A was immediately implanted with a porous mineralized collagen plug and covered with a bilayer mineralized collagen-guided bone regenera...
Source: Journal of Biomaterials Applications - March 23, 2016 Category: Materials Science Authors: Sun, Y., Wang, C.-Y., Wang, Z.-Y., Cui, Y., Qiu, Z.-Y., Song, T.-X., Cui, F.-Z. Tags: Hard Tissues and Materials Source Type: research

In vitro three-dimensional coculturing poly3-hydroxybutyrate-co-3-hydroxyhexanoate with mouse-induced pluripotent stem cells for myocardial patch application
This study aimed to investigate the effect of the novel polymer material, poly3-hydroxybutyrate-co-3-hydroxyhexanoate, on the adhesion, proliferation, and differentiation of mouse-induced pluripotent stem cells in vitro. Mouse-induced pluripotent stem cells were isolated, expanded, and cultured on either two-dimensional or three-dimensional poly3-hydroxybutyrate-co-3-hydroxyhexanoate films (membranes were perforated to imitate three-dimensional space). Following attachment onto the films, mouse-induced pluripotent stem cell morphology was visualized using scanning electron microscopy. Cell vitality was detected using ...
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Shijun, X., Junsheng, M., Jianqun, Z., Ping, B. Tags: Soft Tissues and Material Source Type: research

Mechanics, degradability, bioactivity, in vitro, and in vivo biocompatibility evaluation of poly(amino acid)/hydroxyapatite/calcium sulfate composite for potential load-bearing bone repair
A ternary composite of poly(amino acid), hydroxyapatite, and calcium sulfate (PAA/HA/CS) was prepared using in situ melting polycondensation method and evaluated in terms of mechanical strengths, in vitro degradability, bioactivity, as well as in vitro and in vivo biocompatibility. The results showed that the ternary composite exhibited a compressive strength of 147 MPa, a bending strength of 121 MPa, a tensile strength of 122 MPa, and a tensile modulus of 4.6 GPa. After immersion in simulated body fluid, the compressive strength of the composite decreased from 147 to 98 MPa for six weeks and the bending str...
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Fan, X., Ren, H., Luo, X., Wang, P., Lv, G., Yuan, H., Li, H., Yan, Y. Tags: Hard Tissues and Materials Source Type: research

Promoting spinal fusions by biomineralized silk fibroin films seeded with bone marrow stromal cells: An in vivo animal study
Conclusion The mineralized silk fibroin resembles natural bone structurally, and the cellular and mineral layers of silk fibroin are both critical to bone regeneration. The ability to promote spinal fusion is enhanced when the mineralized silk fibroin is seeded with bone marrow stromal cells. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Gu, Y., Chen, L., Niu, H.-Y., Shen, X.-F., Yang, H.-L. Tags: Hard Tissues and Materials Source Type: research

Engineering bone-implant integration with photofunctionalized titanium microfibers
In conclusion, bone ingrowth occurred in photofunctionalized titanium microfiber scaffolds, enabling successful bone-implant integration when the microfiber-enfolded implants were placed in a site without primary bone support. The combined use of titanium microfibers and photofunctionalization may provide a novel and effective strategy to regenerate and integrate bone in a wider range of applications. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Park, W., Ishijima, M., Hirota, M., Soltanzadeh, P., Ogawa, T. Tags: Hard Tissues and Materials Source Type: research

Functionalized graphene oxide-based thermosensitive hydrogel for near-infrared chemo-photothermal therapy on tumor
Conclusions Docetaxel–graphene oxide/chitosan gel in combination with 808 nm near-infrared laser irradiation had great potential for cancer chemo-photothermal therapy. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Zhu, X., Zhang, Y., Huang, H., Zhang, H., Hou, L., Zhang, Z. Tags: Functional Biomaterials Surfaces Source Type: research

Modulation of osteoblast behavior on TiNxOy coatings by altering the N/O stoichiometry while maintaining a high thrombogenic potential
Conclusions The effect of TiNxOy coatings on osteoblast is dependent on their chemical composition; it increases with the amount of oxygen. TiNxOy coatings may act as a catalyst for cell-adhesion and proliferation early after seeding. In contrast, thrombogenicity of Ti-SLA surface is not affected by TiNxOy application. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Moussa, M., Fontana, P., Hamdan, F., Cattani-Lorente, M., Scherrer, S. S., Banakh, O., Wiskott, A. H., Durual, S. Tags: Functional Biomaterials Surfaces Source Type: research

Formation mechanism and biological activity of novel thiolated human-like collagen iron complex
To develop an iron supplement that is effectively absorbed and utilized, thiolated human-like collagen was created to improve the iron binding capacity of human-like collagen. A thiolated human-like collagen-iron complex was prepared in a phosphate buffer, and one mole of thiolated human-like collagen-iron possessed approximately 28.83 moles of iron. The characteristics of thiolated human-like collagen-iron were investigated by ultraviolet–visible absorption spectroscopy, Fourier transform infrared spectroscopy, circular dichroism, and differential scanning calorimetry. The results showed that the thiolated human-lik...
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Zhu, C., Liu, L., Deng, J., Ma, X., Hui, J., Fan, D. Tags: Functional Biomaterials Surfaces Source Type: research

Osteoblast functions in functionally graded Ti-6Al-4 V mesh structures
We describe here the combined efforts of engineering and biological sciences as a systemic approach to fundamentally elucidate osteoblast functions in functionally graded Ti-6Al-4 V mesh structures in relation to uniform/monolithic mesh arrays. First, the interconnecting porous architecture of functionally graded mesh arrays was conducive to cellular functions including attachment, proliferation, and mineralization. The underlying reason is that the graded fabricated structure with cells seeded from the large pore size side provided a channel for efficient transfer of nutrients to other end of the structure (small pore siz...
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Nune, K., Kumar, A., Misra, R., Li, S., Hao, Y., Yang, R. Tags: Biomaterials Processing Source Type: research

Three-dimensional plotted hydroxyapatite scaffolds with predefined architecture: comparison of stabilization by alginate cross-linking versus sintering
Scaffolds for bone tissue engineering are essentially characterized by porous three-dimensional structures with interconnected pores to facilitate the exchange of nutrients and removal of waste products from cells, thereby promoting cell proliferation in such engineered scaffolds. Although hydroxyapatite is widely being considered for bone tissue engineering applications due to its occurrence in the natural extracellular matrix of this tissue, limited reports are available on additive manufacturing of hydroxyapatite-based materials. In this perspective, hydroxyapatite-based three-dimensional porous scaffolds with two diffe...
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Kumar, A., Akkineni, A. R., Basu, B., Gelinsky, M. Tags: Biomaterials Processing Source Type: research

Comparison of four decontamination treatments on porcine renal decellularized extracellular matrix structure, composition, and support of human renal cortical tubular epithelium cells
In this study, we compared four decontamination treatments that could be applicable to whole porcine kidneys: 70% ethanol, 0.2% peracetic acid in 1 M NaCl, 0.2% peracetic acid in 4% ethanol, and gamma ()-irradiation. Porcine kidneys were decellularized by perfusion of 0.5% (w/v) aqueous solution of sodium dodecyl sulfate and the four decontamination treatments were optimized using segments (n = 60) of renal tissue to ensure a consistent comparison. Although all four methods were successful in decontamination, -irradiation was very damaging to collagen fibers and glycosaminoglycans, leading to less proliferation of human re...
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Poornejad, N., Nielsen, J. J., Morris, R. J., Gassman, J. R., Reynolds, P. R., Roeder, B. L., Cook, A. D. Tags: Biomaterials Processing Source Type: research

Comparison of drug release from poly(lactide-co-glycolide) microspheres and novel fibre formulations
Intraperitoneal cisplatin delivery has recently been shown to benefit ovarian cancer patients. Cisplatin-containing poly(lactide-co-glycolide) (PLGA) microspheres have been proposed for cisplatin delivery. The drug loading of cisplatin containing microspheres produced elsewhere is 3–10%w. Similar microspheres are reported here with a mean diameter of 38.8 µm, and a drug loading of 11.7%w, but using ethyl acetate as a safer solvent. In addition, novel formulations of cisplatin-containing solid and hollow PLGA 65:35 (lactide:glycolide) fibres were prepared and are reported here for the first time. PLGA hollow fib...
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Campbell, C. S., Delgado-Charro, M. B., Camus, O., Perera, S. Tags: Nanotechnology in Biomaterials Source Type: research

Radiosensitization of TPGS-emulsified docetaxel-loaded poly(lactic-co-glycolic acid) nanoparticles in CNE-1 and A549 cells
In conclusion, tocopheryl polyethylene glycol 1000 succinate-emulsified docetaxel-loaded PLGA nanoparticles were more efficacious and fewer adverse effects were observed than with the commercial docetaxel formulation. Thus, PLGA nanoparticles hold promise as a radiosensitizing agent. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - March 11, 2016 Category: Materials Science Authors: Shi, W., Yuan, Y., Chu, M., Zhao, S., Song, Q., Mu, X., Xu, S., Zhang, Z., Yang, K. Tags: Nanotechnology in Biomaterials Source Type: research

Slow chlorine releasing compounds: A viable sterilisation method for bioabsorbable nanocomposite biomaterials
Conclusion SDIC sterilisation can be safely applied to biodegradable scaffolds unsuitable for the more common sterilisation methods. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - February 9, 2016 Category: Materials Science Authors: Naderi, N., Griffin, M., Malins, E., Becer, R., Mosahebi, A., Whitaker, I. S., Seifalian, A. M. Tags: Functional Biomaterials Surfaces Source Type: research