Journal of Biomaterials Applications This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications
The purpose of the present study was to fabricate polymeric nanoparticles as drug carriers for encapsulated curcumin with enhanced anti-colorectal cancer applications. Nanoparticles were formulated from chitosan and gum arabic, natural polysaccharides, via an emulsification solvent diffusion method. The formation of curcumin nanoparticles was confirmed by Fourier transform infrared spectroscopy and differential scanning calorimeter. The results show that curcumin was entrapped in carriers with +48 mV, 136 nm size, and high encapsulation efficiency (95%). Based on an in vitro release study, we inferred that curcumin na...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Udompornmongkol, P., Chiang, B.-H. Tags: Nanotechnology in Biomaterials Source Type: research

Evaluation of a porosity measurement method for wet calcium phosphate cements
The porosity of a calcium phosphate cement is a key parameter as it affects several important properties of the cement. However, a successful, non-destructive porosity measurement method that does not include drying has not yet been reported for calcium phosphate cements. The aim of this study was to evaluate isopropanol solvent exchange as such a method. Two different types of calcium phosphate cements were used, one basic (hydroxyapatite) and one acidic (brushite). The cements were allowed to set in an aqueous environment and then immersed in isopropanol and stored under three different conditions: at room temperature, a...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Ajaxon, I., Maazouz, Y., Ginebra, M.-P., Öhman, C., Persson, C. Tags: Hard Tissues and Materials Source Type: research

Poly(L-lactide)/halloysite nanotube electrospun mats as dual-drug delivery systems and their therapeutic efficacy in infected full-thickness burns
In this study, poly(l-lactide) (PLLA)/halloysite nanotube (HNT) electrospun mats were prepared as a dual-drug delivery system. HNTs were used to encapsulate polymyxin B sulphate (a hydrophilic drug). Dexamethasone (a hydrophobic drug) was directly dissolved in the PLLA solution. The drug-loaded HNTs with optimised encapsulation efficiency were then mixed with the PLLA solution for subsequent electrospinning to form composite dual-drug-loaded fibre mats. The structure, morphology, degradability and mechanical properties of the electrospun composite mats were characterised in detail. The results showed that the HNTs were uni...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Zhang, X., Guo, R., Xu, J., Lan, Y., Jiao, Y., Zhou, C., Zhao, Y. Tags: Soft Tissues and Materials Source Type: research

Investigating the addition of SiO2-CaO-ZnO-Na2O-TiO2 bioactive glass to hydroxyapatite: Characterization, mechanical properties and bioactivity
Hydroxyapatite (Ca10(PO4)6(OH)2) is widely investigated as an implantable material for hard tissue restoration due to its osteoconductive properties. However, hydroxyapatite in bulk form is limited as its mechanical properties are insufficient for load-bearing orthopedic applications. Attempts have been made to improve the mechanical properties of hydroxyapatite, by incorporating ceramic fillers, but the resultant composite materials require high sintering temperatures to facilitate densification, leading to the decomposition of hydroxyapatite into tricalcium phosphate, tetra-calcium phosphate and CaO phases. One method of...
Source: Journal of Biomaterials Applications - December 4, 2015 Category: Materials Science Authors: Yatongchai, C., Placek, L. M., Curran, D. J., Towler, M. R., Wren, A. W. Tags: Biomaterials Processing Source Type: research

Timolol maleate release from hyaluronic acid-containing model silicone hydrogel contact lens materials
This study was designed to assess the impact of a releasable wetting agent, such as hyaluronic acid (HA), on the release profile of timolol maleate (TM) from model silicone hydrogel contact lens materials. Polyvinylpyrrolidone (PVP) was used as an alternative wetting agent for comparison. The model lenses consisted of a hydrophilic monomer, either 2-hydroxyethyl methacrylate or N,N-dimethylacrylamide and a hydrophobic silicone monomer of methacryloxypropyltris (trimethylsiloxy) silane. The loading of the wetting and the therapeutic agent occurred during the synthesis of the silicone hydrogels through the method of direct e...
Source: Journal of Biomaterials Applications - September 21, 2015 Category: Materials Science Authors: Korogiannaki, M., Guidi, G., Jones, L., Sheardown, H. Tags: Soft Tissues and Materials Source Type: research

Codelivery of paclitaxel and small interfering RNA by octadecyl quaternized carboxymethyl chitosan-modified cationic liposome for combined cancer therapy
In conclusion, the results indicate that cationic liposome could be further developed as a codelivery system for chemotherapy drugs and therapeutic small interfering RNAs. (Source: Journal of Biomaterials Applications)
Source: Journal of Biomaterials Applications - September 21, 2015 Category: Materials Science Authors: Zhang, R., Wang, S.-B., Chen, A.-Z., Chen, W.-G., Liu, Y.-G., Wu, W.-G., Kang, Y.-Q., Ye, S.-F. Tags: Nanotechnology in Biomaterials Source Type: research

Feasibility of silica-hybridized collagen hydrogels as three-dimensional cell matrices for hard tissue engineering
Exploiting hydrogels for the cultivation of stem cells, aiming to provide them with physico-chemical cues suitable for osteogenesis, is a critical demand for bone engineering. Here, we developed hybrid compositions of collagen and silica into hydrogels via a simple sol-gel process. The physico-chemical and mechanical properties, degradation behavior, and bone-bioactivity were characterized in-depth; furthermore, the in vitro mesenchymal stem cell growth and osteogenic differentiation behaviors within the 3D hybrid gel matrices were communicated for the first time. The hydrolyzed and condensed silica phase enabled chem...
Source: Journal of Biomaterials Applications - September 21, 2015 Category: Materials Science Authors: Yu, H.-S., Lee, E.-J., Seo, S.-J., Knowles, J. C., Kim, H.-W. Tags: Hard Tissues and Materials Source Type: research

Synthesis of bio-based thermoplastic polyurethane elastomers containing isosorbide and polycarbonate diol and their biocompatible properties
A new family of highly elastic polyurethanes (PUs) partially based on renewable isosorbide were prepared by reacting hexamethylene diisocyanate with a various ratios of isosorbide and polycarbonate diol 2000 (PCD) via a one-step bulk condensation polymerization without catalyst. The influence of the isorsorbide/PCD ratio on the properties of the PU was evaluated. The successful synthesis of the PUs was confirmed by Fourier transform-infrared spectroscopy and 1H nuclear magnetic resonance. The resulting PUs showed high number-average molecular weights ranging from 56,320 to 126,000 g mol–1 and tunable Tg values from &...
Source: Journal of Biomaterials Applications - September 21, 2015 Category: Materials Science Authors: Oh, S.-Y., Kang, M.-S., Knowles, J. C., Gong, M.-S. Tags: Hard Tissues and Materials Source Type: research

Reconstructing spinal dura-like tissue using electrospun poly(lactide-co-glycolide) membranes and dermal fibroblasts to seamlessly repair spinal dural defects in goats
Many neuro- and spinal surgeries involving access to the underlying nervous tissue will cause defect of spinal dural mater, further resulting in cerebrospinal fluid leakage. The current work was thus aimed to develop a package which included two layers of novel electrospun membranes, dermal fibroblasts and mussel adhesive protein for repairing spinal dural defect. The inner layer is electrospun fibrous poly(lactide-co-glycolide) membrane with oriented microstructure (O-poly(lactide-co-glycolide)), which was used as a substrate to anchor dermal fibroblasts as seed cells to reconstitute dura-like tissue via tissue engineerin...
Source: Journal of Biomaterials Applications - September 21, 2015 Category: Materials Science Authors: Yu, F., Li, Q., Yin, S., Liao, X., Huang, F., Chen, D., Cao, Y., Cen, L. Tags: Hard Tissues and Materials Source Type: research

Strontium- and calcium-containing, titanium-stabilised phosphate-based glasses with prolonged degradation for orthopaedic tissue engineering
Strontium- and calcium-releasing, titanium-stabilised phosphate-based glasses with a controlled degradation rate are currently under development for orthopaedic tissue engineering applications. Ca and/or Sr were incorporated at varying concentrations in quaternary phosphate-based glasses, in order to promote osteoinduction. Ti was incorporated at a fixed concentration in order to prolong degradation. Glasses of the general formula (P2O5)–(Na2O)–(TiO2)–(CaO)–(SrO) were prepared via the melt-quench technique. The materials were characterised by energy-dispersive X-ray spectroscopy, X-ray diffraction, ...
Source: Journal of Biomaterials Applications - September 21, 2015 Category: Materials Science Authors: Al Qaysi, M., Walters, N. J., Foroutan, F., Owens, G. J., Kim, H.-W., Shah, R., Knowles, J. C. Tags: Hard Tissues and Materials Source Type: research

Icariin: A promising osteoinductive compound for repairing bone defect and osteonecrosis
Icariin (Ica), the main active component of Herba Epimedii, has been identified as an osteogenic and angiogenic phytomolecule. To develop a bioactive scaffold for enhancing bone repair, Ica was loaded into porous tricalcium phosphate (TCP) scaffolds, and the obtained porous Ica/TCP composites were investigated for treating osteonecrosis of the femoral head (ONFH) in a rabbit model. ONFH was histopathologically confirmed at two weeks after methylprednisolone acetate injection, and the rabbits were treated with porous Ica/TCP scaffolds (group A), porous TCP scaffolds (group B), and autogenous cancellous bone graft (group C)....
Source: Journal of Biomaterials Applications - September 21, 2015 Category: Materials Science Authors: Xie, X., Pei, F., Wang, H., Tan, Z., Yang, Z., Kang, P. Tags: Hard Tissues and Materials Source Type: research

The effect of unsaturated fatty acid and triglyceride oil addition on the mechanical and antibacterial properties of acrylic bone cements
In this study, several types of fatty acids and triglyceride oils were evaluated for use in acrylic bone cements. Their mechanical properties were evaluated under uniaxial compression testing and selected cements were then further characterized in terms of microstructure, handling and antibacterial properties using scanning electron microscopy, polymerization temperature measurements, agar diffusion tests and bactericidal activity assays of cement extracts. It was found that any of the evaluated fatty acids or triglyceride oils could be used to tailor the stiffness of acrylic bone cements, although at varying concentration...
Source: Journal of Biomaterials Applications - September 21, 2015 Category: Materials Science Authors: Persson, C., Robert, E., Carlsson, E., Robo, C., Lopez, A., Godoy-Gallardo, M., Ginebra, M.-P., Engqvist, H. Tags: Hard Tissues and Materials Source Type: research

Study on inhibitory activity of chitosan-based materials against biofilm producing Pseudomonas aeruginosa strains
Six antibiotic-resistant Pseudomonas aeruginosa strains, isolated from chronic diabetic foot infections, were chosen for studying the influence of different chitosan-based materials: chitosan solution and chitosan submicroparticles in both planktonic and 24 h-old biofilm-forming models. Chitosan solution occurred to be more effective in the reduction of bacterial populations than chitosan submicroparticles for both planktonic and biofilm-related Pseudomonas cells. It seems that the antimicrobial activity of the tested chitosan preparations depends on the individual bacterial strain susceptibility probably related to differ...
Source: Journal of Biomaterials Applications - September 21, 2015 Category: Materials Science Authors: Machul, A., Mikołajczyk, D., Regiel-Futyra, A., Heczko, P. B., Strus, M., Arruebo, M., Stochel, G., Kyzioł, A. Tags: Functional biomaterials surfaces Source Type: research

In vivo delivery of functional Flightless I siRNA using layer-by-layer polymer surface modification
This study aimed to investigate whether layer-by-layer polymer surface modification could deliver small interfering RNA to decrease fibrotic processes associated with medical device implantation. Anti-green fluorescent protein labelled small interfering RNA was applied to tissue culture plates and polyurethane using a layer-by-layer technique with small interfering RNA and poly-L-lysine. In vitro studies showed that the level of down-regulation of green fluorescent protein was directly related to the number of coatings applied. This layer-by-layer coating technique was then used to generate Rhodamine-Flii small interf...
Source: Journal of Biomaterials Applications - September 21, 2015 Category: Materials Science Authors: Martens, P. J., Ly, M., Adams, D. H., Penzkover, K. R., Strudwick, X., Cowin, A. J., Poole-Warren, L. A. Tags: Biomaterials Processing Source Type: research

Characterisation of porcine dermis scaffolds decellularised using a novel non-enzymatic method for biomedical applications
This study assessed the effect of five different decellularisation methods on porcine dermal scaffolds with regard to matrix composition, biomechanical strength, and cytotoxicity using an in vitro biocompatibility assay. Results demonstrated that four out of the five tested decellularisation protocols were efficient in producing acellular scaffolds. Nevertheless, decellularisation method using osmotic shock without enzymatic digestion showed to be efficient not only in removing cellular material and debris from dermal scaffolds but was also beneficial in the preservation of extracellular matrix components (glycosaminoglyca...
Source: Journal of Biomaterials Applications - July 7, 2015 Category: Materials Science Authors: Greco, K., Francis, L., Somasundaram, M., Greco, G., English, N. R., Roether, J. A., Boccaccini, A. R., Sibbons, P., Ansari, T. Tags: Soft Tissues and Materials Source Type: research