Global and Regional Brain Non-Gaussian Diffusion Changes in Newly Diagnosed Patients with Obstructive Sleep Apnea
Conclusions:Global mean kurtosis values are significantly increased in obstructive sleep apnea (OSA), suggesting acute tissue injury, and these changes are principally localized in critical sites mediating deficient functions in the condition. The mechanisms for injury likely include altered perfusion and hypoxemia-induced processes, leading to acute tissue changes in recently diagnosed OSA.Citation:Tummala S, Palomares J, Kang DW, Park B, Woo MA, Harper RM, Kumar R. Global and regional brain non-gaussian diffusion changes in newly diagnosed patients with obstructive sleep apnea. SLEEP 2016;39(1):51–57. (Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
Maxillomandibular Volume Influences the Relationship between Weight Loss and Improvement in Obstructive Sleep Apnea
Conclusion:Maxillomandibular volume influences the relationship between weight loss and OSA improvement with an effect on AHI more evident in those with a smaller craniofacial skeleton.Citation:Sutherland K, Phillips CL, Yee BJ, Grunstein RR, Cistulli PA. Maxillomandibular volume influences the relationship between weight loss and improvement in obstructive sleep apnea. SLEEP 2016;39(1):43–49. (Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
A Randomized Controlled Trial of Continuous Positive Airway Pressure on Glucose Tolerance in Obese Patients with Obstructive Sleep Apnea
Conclusions:The improvement of glucose tolerance in morbidly obese patients with severe obstructive sleep apnea, without changes in homeostasis model assessment of insulin resistance, supports an improvement in peripheral insulin resistance after continuous positive airway pressure treatment.Clinical Trials Registration:NCT 01029561.Citation:Salord N, Fortuna AM, Monasterio C, Gasa M, Pérez A, Bonsignore MR, Vilarrasa N, Montserrat JM, Mayos M. A randomized controlled trial of continuous positive airway pressure on glucose tolerance in obese patients with obstructive sleep apnea. SLEEP 2016;39(1):35–41. (Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
Increased Muscle Sympathetic Nerve Activity and Impaired Executive Performance Capacity in Obstructive Sleep Apnea
Conclusions:As compared to controls, MSNA is increased in patients with OSA at rest, and further significant MSNA increments and worse executive performance are seen during mental stress.Clinical Trial Registration:URL: http://www.clinicaltrials.gov, registration number: NCT002289625.Citation:Goya TT, Silva RF, Guerra RS, Lima MF, Barbosa ER, Cunha PJ, Lobo DM, Buchpiguel CA, Busatto-Filho G, Negrão CE, Lorenzi-Filho G, Ueno-Pardi LM. Increased muscle sympathetic nerve activity and impaired executive performance capacity in obstructive sleep apnea. SLEEP 2016;39(1):25–33. (Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
Optic Nerve Dysfunction in Obstructive Sleep Apnea: An Electrophysiological Study
Conclusions:This study documented that patients with OSA, without medical comorbidities, present VEP alteration as documented by lower amplitude and longer latency of the P100 component than healthy controls. These altered electrophysiological findings may be the expression of optic nerve dysfunction provoked by hypoxia, acidosis, hypercarbia and airway obstruction, frequently observed in patients with OSA. Hence, we hypothesize that OSA per se may impair optic nerve function.Citation:Liguori C, Palmieri MG, Pierantozzi M, Cesareo M, Romigi A, Izzi F, Marciani MG, Oliva C, Mercuri NB, Placidi F. Optic nerve dysfunction in ...
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
Fragmented Sleep and Cortical Thinning in Old Adults: Time to Wake Up?
(Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
The Promise of Digital CBT-I
(Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
Locus Coeruleus Neural Fatigue: A Potential Mechanism for Cognitive Impairment during Sleep Deprivation
(Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
Expanded Insights into Idiopathic REM Sleep Behavior Disorder
(Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
Chapter 5 Journal SLEEP
(Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
Predictors for Development of Excessive Daytime Sleepiness in Women: A Population-Based 10-Year Follow-Up
Conclusion:Insomnia, anxiety and/or depression, and smoking were the most important factors for predicting incident excessive daytime sleepiness (EDS) and, in addition, somatic disease, obesity, and snoring predicted EDS. It is important not only to treat these conditions but also to inform women of the importance of a healthy lifestyle in order to prevent and reduce EDS in women.Citation:Theorell-Haglöw J, Åkerstedt T, Schwarz J, Lindberg E. Predictors for development of excessive daytime sleepiness in women: a population-based 10-year follow-up. SLEEP 2015;38(12):1995–2003. (Source: Sleep)
Source: Sleep - December 1, 2015 Category: Sleep Medicine Source Type: research
Insomnia Caused by Serotonin Depletion is Due to Hypothermia
Conclusions:These results indicate that early experiments using para-chlorophenylalanine that led to the conclusion that 5-hydroxytryptamine (5-HT) causes sleep were likely confounded by hypothermia. Temperature controls should be considered in experiments using 5-HT depletion.Citation:Murray NM, Buchanan GF, Richerson GB. Insomnia caused by serotonin depletion is due to hypothermia. SLEEP 2015;38(12):1985–1993. (Source: Sleep)
Source: Sleep - December 1, 2015 Category: Sleep Medicine Source Type: research
Allergies and Disease Severity in Childhood Narcolepsy: Preliminary Findings
Conclusion:Involvement of the immune system plays an important role in the pathophysiology of narcolepsy. Current findings further suggest that an increased shift toward T helper 2 cells, as indicated by the presence of allergic conditions, may modulate the severity of the phenotype in childhood narcolepsy, and reduce the prevalence of cataplexy in these patients.Citation:Aydinoz S, Huang YS, Gozal D, Inocente CO, Franco P, Kheirandish-Gozal L. Allergies and disease severity in childhood narcolepsy: preliminary findings. SLEEP 2015;38(12):1981–1984. (Source: Sleep)
Source: Sleep - December 1, 2015 Category: Sleep Medicine Source Type: research
Blood Pressure Increases in OSA due to Maintained Neurovascular Sympathetic Transduction: Impact of CPAP
Conclusions:Greater sympathetic activity in obstructive sleep apnea does not appear to be associated with lesser neurovascular transduction. Hence, elevated sympathetic outflow without lesser transduction may underlie the prevalent development of hypertension in this population that is well controlled by continuous positive airway pressure treatment.Citation:Tamisier R, Tan CO, Pepin JL, Levy P, Taylor JA. Blood pressure increases in OSA due to maintained neurovascular sympathetic transduction: impact of CPAP. SLEEP 2015;38(12):1973–1980. (Source: Sleep)
Source: Sleep - December 1, 2015 Category: Sleep Medicine Source Type: research
Sleepiness and Cognitive Performance among Younger and Older Adolescents across a 28-Hour Forced Desynchrony Protocol
Conclusions:Adolescents demonstrated a similar pattern of response to forced desynchrony as reported for adults. Sleepiness and performance were affected by homeostatic and circadian factors, and age group did not interact with homoeostatic and circadian factors for subjective sleepiness and most performance metrics. Younger adolescents had a shorter latency to sleep onset than older during the circadian bin spanning 4 to 8 h after the onset of melatonin secretion.Citation:Wu LJ, Acebo C, Seifer R, Carskadon MA. Sleepiness and cognitive performance among younger and older adolescents across a 28-hour forced desynchrony pro...
Source: Sleep - December 1, 2015 Category: Sleep Medicine Source Type: research
