Orexin-A is Associated with Increases in Cerebrospinal Fluid Phosphorylated-Tau in Cognitively Normal Elderly Subjects
Conclusions:
Orexin-A is associated with increased P-Tau in normal elderly individuals. Increases in orexin-A and P-Tau might be a consequence of the reduction in the proportion of the deeper, more restorative slow wave sleep and rapid eye movement sleep reported with aging.
Clinical Trial Registration:
Clinicaltrials.gov registration number NCT01962779.
Citation:
Osorio RS, Ducca EL, Wohlleber ME, Tanzi EB, Gumb T, Twumasi A, Tweardy S, Lewis C, Fischer E, Koushyk V, Cuartero-Toledo M, Sheikh MO, Pirraglia E, Zetterberg H, Blennow K, Lu SE, Mosconi L, Glodzik L, Schuetz S, Varga AW, Ayappa I, Rapoport DM, de Leon MJ. ...
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Damage to Arousal-Promoting Brainstem Neurons with Traumatic Brain Injury
Conclusions:TBI injures arousal-promoting neurons of the mesopontine tegmentum, but this injury is less severe than previously observed in hypothalamic arousal-promoting neurons. Most likely, posttraumatic arousal disturbances are not primarily caused by damage to these brainstem neurons, but arise from an aggregate of injuries, including damage to hypothalamic arousal nuclei and disruption of other arousal-related circuitries.Citation:Valko PO, Gavrilov YV, Yamamoto M, Noain D, Reddy H, Haybaeck J, Weis S, Baumann CR, Scammell TE. Damage to arousal-promoting brainstem neurons with traumatic brain injury. SLEEP 2016;39(6):...
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Circadian Rest-Activity Rhythm in Pediatric Type 1 Narcolepsy
Conclusions:Actigraphy reliably renders the nycthemeral disruption typical of narcolepsy type 1 in drug-naïve children with recent disease onset, indicating the sensibility of actigraphic assessment in the diagnostic work-up of childhood narcolepsy type 1.Citation:Filardi M, Pizza F, Bruni O, Natale V, Plazzi G. Circadian rest-activity rhythm in pediatric type 1 narcolepsy. SLEEP 2016;39(6):1241–1247. (Source: Sleep)
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
EEG Changes across Multiple Nights of Sleep Restriction and Recovery in Adolescents: The Need for Sleep Study
Conclusions:In spite of preservation of SWS duration over multiple nights of sleep restriction, adolescents accustomed to curtailing nocturnal sleep on school day nights evidence residual effects on sleep macro-structure, even after three nights of recovery sleep. Older teenagers may not be as resilient to successive nights of sleep restriction as is commonly believed.Citation:Ong JL, Lo JC, Gooley JJ, Chee MW. EEG changes across multiple nights of sleep restriction and recovery in adolescents: the need for sleep study. SLEEP 2016;39(6):1233–1240. (Source: Sleep)
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Biomarkers of Alzheimer Disease in Children with Obstructive Sleep Apnea: Effect of Adenotonsillectomy
Conclusions:
Thus, OSA, and particularly OSA+OB, are associated with increased plasma levels of AD biomarkers, which decline upon treatment of OSA in a representative, yet not all- encompassing subset of patients, suggesting that OSA may accelerate AD-related processes even in early childhood. However, the cognitive and overall health-related implications of these findings remain to be defined.
Citation:
Kheirandish-Gozal L, Philby MF, Alonso-Álvarez ML, Terán-Santos J, Gozal D. Biomarkers of Alzheimer disease in children with obstructive sleep apnea: effect of adenotonsillectomy. SLEEP 2016;39(6):1225&ndas...
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Validation of Actigraphy in Middle Childhood
Conclusions:This study adds to the small existing literature demonstrating the validity of actigraphy in middle childhood. Although actigraphy shows good sensitivity (ability to detect sleep), specificity (ability to detect wake) is poor in this age group. Further, the results highlight the importance of considering whether a child has PLMS when interpreting actigraphic data, as well as the difficulties in accurately capturing sleep onset latency with actigraphy.Citation:Meltzer LJ, Wong P, Biggs SN, Traylor J, Kim JY, Bhattacharjee R, Narang I, Marcus CL. Validation of actigraphy in middle childhood. SLEEP 2016;39(6):1219...
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Risk of Occupational Accidents in Workers with Obstructive Sleep Apnea: Systematic Review and Meta-analysis
Conclusions:OSA is an underdiagnosed nonoccupational disease that has a strong adverse effect on work accidents. The nearly twofold increased odds of work accidents in subjects with OSA calls for workplace screening in selected safety-sensitive occupations.Commentary:A commentary on this article appears in this issue on page 1171.Citation:Garbarino S, Guglielmi O, Sanna A, Mancardi GL, Magnavita N. Risk of occupational accidents in workers with obstructive sleep apnea: systematic review and meta-analysis. SLEEP 2016;39(6):1211–1218. (Source: Sleep)
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Continuous Positive Airway Pressure and Breathlessness in Obese Patients with Obstructive Sleep Apnea: A Pilot Study
Conclusions:
Awake, the respiratory system is maximally offloaded with lower than therapeutic CPAP levels in obese patients with OSA. Levels of NRD observed at effective CPAP levels while asleep are associated with breathlessness which may limit long-term CPAP compliance.
Citation:
Xiao S, Bastianpillai J, Ratneswaran C, Pengo MF, Luo Y, Jolley CJ, Moxham J, Steier J. Continuous positive airway pressure and breathlessness in obese patients with obstructive sleep apnea: a pilot study. SLEEP 2016;39(6):1201–1210. (Source: Sleep)
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Cerebral and Muscle Oxygenation During Intermittent Hypoxia Exposure in Healthy Humans
Conclusions:Fluctuations of blood oxygen levels comparable to severe obstructive sleep apnea translate into distinct pattern of oxygenation changes in the muscle and cortex.Citation:Rupp T, Peyrard A, Tamisier R, Pepin JL, Verges S. Cerebral and muscle oxygenation during intermittent hypoxia exposure in healthy humans. SLEEP 2016;39(6):1197–1199. (Source: Sleep)
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Effects of Obstructive Sleep Apnea and Obesity on Cardiac Remodeling: The Wisconsin Sleep Cohort Study
Conclusions:OSA is associated independently with decreasing LV systolic function and with reduced RV function. Echocardiographic measures of adverse cardiac remodeling are strongly associated with OSA but are confounded by obesity. Hypoxia may be a stimulus for hypertrophy in individuals with OSA.Citation:Korcarz CE, Peppard PE, Young TB, Chapman CB, Hla KM, Barnet JH, Hagen E, Stein JH. Effects of obstructive sleep apnea and obesity on cardiac remodeling: the Wisconsin Sleep Cohort Study. SLEEP 2016;39(6):1187–1195. (Source: Sleep)
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Inspiratory Muscle Training Improves Sleep and Mitigates Cardiovascular Dysfunction in Obstructive Sleep Apnea
Conclusions:The results are consistent with our previously published findings in normotensive adults but further indicate that IMT can modulate blood pressure and plasma catecholamines in subjects with ongoing nighttime apnea and hypoxemia. Accordingly, we suggest IMT offers a low cost, nonpharmacologic means of improving sleep and blood pressure in patients who are intolerant of CPAP.Citation:Vranish JR, Bailey EF. Inspiratory muscle training improves sleep and mitigates cardiovascular dysfunction in obstructive sleep apnea. SLEEP 2016;39(6):1179–1185. (Source: Sleep)
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Glial Gap Junctions Boost Modafinil Action on Arousal
(Source: Sleep)
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Obstructive Sleep Apnea and Work Accidents: Time for Action
(Source: Sleep)
Source: Sleep - June 1, 2016 Category: Sleep Medicine Source Type: research
Sleep Apnea Severity Classification – Revisited
(Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource
This article reviews the key objectives, challenges and operational solutions to addressing big data opportunities for sleep research in the context of the national sleep research agenda. It provides information to facilitate further interactions of the user community with NSRR, a community resource.Citation:Dean DA, Goldberger AL, Mueller R, Kim M, Rueschman M, Mobley D, Sahoo SS, Jayapandian CP, Cui L, Morrical MG, Surovec S, Zhang GQ, Redline S. Scaling up scientific discovery in sleep medicine: the National Sleep Research Resource. SLEEP 2016;39(5):1151–1164. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
