Brain Damage and Motor Cortex Impairment in Chronic Obstructive Pulmonary Disease: Implication of Nonrapid Eye Movement Sleep Desaturation
Conclusions:Over half the nonhypoxemic COPD patients exhibited NREM sleep desaturation associated with higher values of the cerebral lesion biomarker and lower neural drive reaching the quadriceps during maximal voluntary contraction. The lack of muscle strength differences between groups suggests a compensatory mechanism(s). Altogether, the results are consistent with an involvement of NREM sleep desaturation in COPD brain impairment.Clinical Trial Registration:The study was registered at www.clinicaltrials.gov as NCT01679782.Citation:Alexandre F, Heraud N, Sanchez AM, Tremey E, Oliver N, Guerin P, Varray A. Brain damage ...
Source: Sleep - January 31, 2016 Category: Sleep Medicine Source Type: research
The Effect of Changes in Cardiorespiratory Fitness and Weight on Obstructive Sleep Apnea Severity in Overweight Adults with Type 2 Diabetes
Conclusions:Among overweight/obese adults with type 2 diabetes, fitness change did not influence OSA severity change when weight change was taken into account.Clinical Trial Registration:ClinicalTrials.gov identification number NCT00194259Citation:Kline CE, Reboussin DM, Foster GD, Rice TB, Strotmeyer ES, Jakicic JM, Millman RP, Pi-Sunyer X, Newman AB, Wadden TA, Zammit G, Kuna ST, Sleep AHEAD Research Group. The effect of changes in cardiorespiratory fitness and weight on obstructive sleep apnea severity in overweight adults with type 2 diabetes. SLEEP 2016;39(2):317–325. (Source: Sleep)
Source: Sleep - January 31, 2016 Category: Sleep Medicine Source Type: research
Obstructive Sleep Apnea and 15-Year Cognitive Decline: The Atherosclerosis Risk in Communities (ARIC) Study
Conclusions:Overall, abnormal sleep quality and quantity at midlife was not related to cognitive decline and later-life cognition. The effect of adverse sleep quality and quantity on cognitive decline among the elderly remains to be determined.Citation:Lutsey PL, Bengtson LG, Punjabi NM, Shahar E, Mosley TH, Gottesman RF, Wruck LM, MacLehose RF, Alonso A. Obstructive sleep apnea and 15-year cognitive decline: the Atherosclerosis Risk in Communities (ARIC) study. SLEEP 2016;39(2):309–316. (Source: Sleep)
Source: Sleep - January 31, 2016 Category: Sleep Medicine Source Type: research
The Association between Obstructive Sleep Apnea on Diabetic Kidney Disease: A Systematic Review and Meta-Analysis
Conclusions:There is moderate evidence that OSA is associated with DKD in patients with T2DM. Large prospective studies with long-term follow up are needed to assess the possible bi-directional mechanisms between OSA and DKD.Citation:Leong WB, Jadhakhan F, Taheri S, Thomas GN, Adab P. The association between obstructive sleep apnea on diabetic kidney disease: a systematic review and meta-analysis. SLEEP 2016;39(2):301–308. (Source: Sleep)
Source: Sleep - January 31, 2016 Category: Sleep Medicine Source Type: research
Serum Vitamin D Is Significantly Inversely Associated with Disease Severity in Caucasian Adults with Obstructive Sleep Apnea Syndrome
Conclusions:We observed widespread vitamin D deficiency and insufficiency in a Caucasian, OSAS population. There were significant, independent, inverse relationships between 25(OH)D and AHI as well as nocturnal HR, a known cardiovascular risk factor. Further, 25(OH)D was significantly lower in OSAS cases compared to matched, non-OSAS subjects. We provide evidence that 25(OH)D and OSAS are related, but the role, if any, of replenishment has not been investigated.Citation:Kerley CP, Hutchinson K, Bolger K, McGowan A, Faul J, Comican L. Serum vitamin D is significantly inversely associated with disease severity in Caucasian a...
Source: Sleep - January 31, 2016 Category: Sleep Medicine Source Type: research
C-reactive Protein as a Potential Biomarker of Residual Obstructive Sleep Apnea Following Adenotonsillectomy in Children
Conclusions:Even though AT improves OSA in most children, residual OSA is frequent. Assessment of post-AT hsCRP levels emerges as a potentially useful biomarker predicting residual OSA.Citation:Bhattacharjee R, Kheirandish-Gozal L, Kaditis AG, Verhulst SL, Gozal D. C-reactive protein as a potential biomarker of residual obstructive sleep apnea following adenotonsillectomy in children. SLEEP 2016;39(2):283–291. (Source: Sleep)
Source: Sleep - January 31, 2016 Category: Sleep Medicine Source Type: research
Longitudinal Outcomes of Start Time Delay on Sleep, Behavior, and Achievement in High School
Conclusions:Later start times improved tardiness and disciplinary issues at this school district. A delay in start time may be a necessary but not sufficient means to increase sleep time and may depend on preexisting individual differences.Commentary:A commentary on this article appears in this issue on page 267.Citation:Thacher PV, Onyper SV. Longitudinal outcomes of start time delay on sleep, behavior, and achievement in high school. SLEEP 2016;39(2):271–281. (Source: Sleep)
Source: Sleep - January 31, 2016 Category: Sleep Medicine Source Type: research
How Much Day-To-Day Variability in Sleep Timing Is Unhealthy?
(Source: Sleep)
Source: Sleep - January 31, 2016 Category: Sleep Medicine Source Type: research
Healthy School Start Times: Can We Do a Better Job in Reaching Our Goals?
(Source: Sleep)
Source: Sleep - January 31, 2016 Category: Sleep Medicine Source Type: research
A Unified Model of Performance: Validation of its Predictions across Different Sleep/Wake Schedules
Conclusions:The unified model of performance can be used as a tool to help design sleep/wake schedules to optimize the extent and duration of neurobehavioral performance and to accelerate recovery after sleep loss.Citation:Ramakrishnan S, Wesensten NJ, Balkin TJ, Reifman J. A unified model of performance: validation of its predictions across different sleep/wake schedules. SLEEP 2016;39(1):249–262. (Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
A Collaborative Paradigm for Improving Management of Sleep Disorders in Primary Care: A Randomized Clinical Trial
Conclusions:A one-time sleep consultation significantly increased healthcare providers' attention to sleep problems and resulted in benefits to patients' sleep/wake symptoms.Clinical Trials Registration:This study is registered with clinicaltrials.gov with identifier # NCT00390572.Citation:Edinger JD, Grubber J, Ulmer C, Zervakis J, Olsen M. A collaborative paradigm for improving management of sleep disorders in primary care: a randomized clinical trial. SLEEP 2016;39(1):237–247. (Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
Regional Neocortical Gray Matter Structure and Sleep Fragmentation in Older Adults
Conclusions:Lower cortical gray matter volume in the lateral orbitofrontal cortex and inferior frontal gyrus pars orbitalis is associated with greater sleep fragmentation in older community-dwelling adults. Further work is needed to clarify whether this is a consequence of or contributor to sleep fragmentation.Commentary:A commentary on this article appears in this issue on page 15.Citation:Lim AS, Fleischman DA, Dawe RJ, Yu L, Arfanakis K, Buchman AS, Bennett DA. Regional neocortical gray matter structure and sleep fragmentation in older adults. SLEEP 2016;39(1):227–235. (Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
Impaired Sleep Predicts Cognitive Decline in Old People: Findings from the Prospective KORA Age Study
Conclusions:DMS and long sleep duration were associated with cognitive decline in normal and cognitively impaired elderly, respectively. The identification of impaired sleep quality may offer intervention strategies to deter cognitive decline in the elderly with normal cognitive function.Citation:Johar H, Kawan R, Emeny RT, Ladwig KH. Impaired sleep predicts cognitive decline in old people: findings from the prospective KORA age study. SLEEP 2016;39(1):217–226. (Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
Cerebral Blood Flow Response to Hypercapnia in Children with Obstructive Sleep Apnea Syndrome
Conclusions:Children with OSAS and snorers have blunted CBF response to hypercapnia during wakefulness compared to controls. Noninvasive DCS blood flow measurements of hypercapnic reactivity offer insights into physiopathology of OSAS in children, which could lead to further understanding about the central nervous system complications of OSAS.Citation:Busch DR, Lynch JM, Winters ME, McCarthy AL, Newland JJ, Ko T, Cornaglia MA, Radcliffe J, McDonough JM, Samuel J, Matthews E, Xiao R, Yodh AG, Marcus CL, Licht DJ, Tapia IE. Cerebral blood flow response to hypercapnia in children with obstructive sleep apnea syndrome. SLEEP 2...
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
A Daytime Nap Facilitates Generalization of Word Meanings in Young Toddlers
Conclusions:Our results suggest that napping improves generalization in toddlers.Citation:Horváth K, Liu S, Plunkett K. A daytime nap facilitates generalization of word meanings in young toddlers. SLEEP 2016;39(1):203–207. (Source: Sleep)
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research
