Suppression of Sleep Spindle Rhythmogenesis in Mice with Deletion of CaV3.2 and CaV3.3 T-type Ca2+ Channels
Conclusions:
Consistent with previous findings, CaV3.3 channels dominate nRt rhythmogenesis, but the lack of CaV3.2 channels further aggravates neuronal, synaptic, and EEG deficits. Therefore, CaV3.2 channels can boost intrathalamic synaptic transmission, and might play a modulatory role adjusting the relative presence of NREM sleep EEG rhythms.
Citation:
Pellegrini C, Lecci S, Lüthi A, Astori S. Suppression of sleep spindle rhythmogenesis in mice with deletion of CaV3.2 and CaV3.3 T-type Ca2+ channels. SLEEP 2016;39(4):875–885. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Loss of Sleep Affects the Ultrastructure of Pyramidal Neurons in the Adolescent Mouse Frontal Cortex
Conclusions:Ultrastructural analysis may be a powerful tool to identify which cellular organelles, and thus which cellular functions, are most affected by sleep and sleep loss.Citation:de Vivo L, Nelson AB, Bellesi M, Noguti J, Tononi G, Cirelli C. Loss of sleep affects the ultrastructure of pyramidal neurons in the adolescent mouse frontal cortex. SLEEP 2016;39(4):861–874. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Cerebrospinal Fluid Orexin A Levels and Autonomic Function in Kleine-Levin Syndrome
Conclusions:There are lower orexin A levels in the symptomatic phase than in remission and a fall and rise in blood pressure and heart rate, suggesting a role for orexin dysregulation in KLS pathophysiology.Citation:Wang JY, Han F, Dong SX, Li J, An P, Zhang XZ, Chang Y, Zhao L, Zhang XL, Liu YN, Yan H, Li QH, Hu Y, Lv CJ, Gao ZC, Strohl KP. Cerebrospinal fluid orexin A levels and autonomic function in Kleine-Levin syndrome. SLEEP 2016;39(4):855–860. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Spontaneous Swallowing during All-Night Sleep in Patients with Parkinson Disease in Comparison with Healthy Control Subjects
Conclusions:In PD, the rate of SS was not sufficient to demonstrate the swallowing disorder, such as oropharyngeal dysphagia, but the salvo type of SS was quite frequent. This is a novel finding and may contribute to the understanding of swallowing problems in patients with dysphagic or nondysphagic PD.Citation:Uludag IF, Tiftikcioglu BI, Ertekin C. Spontaneous swallowing during all-night sleep in patients with Parkinson disease in comparison with healthy control subjects. SLEEP 2016;39(4):847–854. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Effects of Psychological and Social Work Factors on Self-Reported Sleep Disturbance and Difficulties Initiating Sleep
Conclusions:All work factors investigated showed statistically significant associations with both sleep items, however quantitative job demands, decision control, role conflict, and support from superior were the most robust predictors and may therefore be suitable targets of interventions aimed at improving employee sleep.Citation:Vleeshouwers J, Knardahl S, Christensen JO. Effects of psychological and social work factors on self-reported sleep disturbance and difficulties initiating sleep. SLEEP 2016;39(4):833–846. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Prevalence and Predictors of Prescription Sleep Aid Use among Individuals with DSM-5 Insomnia: The Role of Hyperarousal
Conclusions:
Hyperarousal, as indexed by daytime alertness and anxiety, is a strong determinant of PSA use among individuals with insomnia. These findings are consistent with emerging data showing that insomnia is not just a nocturnal sleep disorder, but one characterized by 24-h arousal. Though current research targets sleep disturbance, this study highlights the role of the arousal system in pharmacological treatment seeking.
Citation:
Pillai V, Cheng P, Kalmbach DA, Roehrs T, Roth T, Drake CL. Prevalence and predictors of prescription sleep aid use among individuals with DSM-5 insomnia: the role of hyperarousal. SLEEP...
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Long-Term Effects of Two Formats of Cognitive Behavioral Therapy for Insomnia Comorbid with Breast Cancer
Conclusions:Although face-to-face therapy remains the optimal format to efficaciously administer CBT for insomnia in cancer patients, a minimal intervention, such as the video-based intervention tested in this study, produces significant and sustainable treatment effects.Clinical Trial Registration:ClinicalTrials.gov identifier NCT00674830.Citation:Savard J, Ivers H, Savard MH, Morin CM. Long-term effects of two formats of cognitive behavioral therapy for insomnia comorbid with breast cancer. SLEEP 2016;39(4):813–823. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Regional Patterns of Elevated Alpha and High-Frequency Electroencephalographic Activity during Nonrapid Eye Movement Sleep in Chronic Insomnia: A Pilot Study
Conclusions:These results suggest that even during the deepest stage of sleep, sensory and sensorimotor areas in insomnia subjects may still be relatively active compared to control subjects and to the rest of the sleeping brain.Citation:Riedner BA, Goldstein MR, Plante DT, Rumble ME, Ferrarelli F, Tononi G, Benca RM. Regional patterns of elevated alpha and high-frequency electroencephalographic activity during nonrapid eye movement sleep in chronic insomnia: a pilot study. SLEEP 2016;39(4):801–812. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Airway Resistance in Children with Obstructive Sleep Apnea Syndrome
Conclusions:Children with OSAS have elevated AR that decreases after treatment. This is likely because of upper airway loading secondary to adenotonsillar hypertrophy and may contribute to the increased frequency of respiratory diseases in untreated children with OSAS.Citation:Tapia IE, Marcus CL, McDonough JM, Kim JY, Cornaglia MA, Xiao R, Allen JL. Airway resistance in children with obstructive sleep apnea syndrome. SLEEP 2016;39(4):793–799. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Sleep Disordered Breathing and White Matter Hyperintensities in Community-Dwelling Elders
Conclusions:In community-dwelling older adults, self-reported measures of SDB are associated with larger WMH volumes. The cognitive effects of SDB that are increasingly being recognized may be mediated at the small vessel level.Citation:Rostanski SK, Zimmerman ME, Schupf N, Manly JJ, Westwood AJ, Brickman AM, Gu Y. Sleep disordered breathing and white matter hyperintensities in community-dwelling elders. SLEEP 2016;39(4):785–791. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Exercise during Short-Term and Long-Term Continuous Exposure to Hypoxia Exacerbates Sleep-Related Periodic Breathing
Conclusions:
Data indicate that exercise (physical activity) per se affects night SpO2 concentrations and AHI after a minimum of two bouts of moderate-intensity hypoxic exercise, while habitual physical activity in hypobaric hypoxic confinement affects breathing during sleep, up to 13+ months' duration
Citation:
Tellez HF, Morrison SA, Neyt X, Mairesse O, Piacentini MF, Macdonald-Nethercott E, Pangerc A, Dolenc-Groselj L, Eiken O, Pattyn N, Mekjavic IB, Meeusen R. Exercise during short-term and long-term continuous exposure to hypoxia exacerbates sleep-related periodic breathing. SLEEP 2016;39(4):773–783. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Association between Snoring and Leukocyte Telomere Length
Conclusions:Our findings suggest that snoring may influence telomere attrition independent of sleep apnea.Citation:Shin C, Yun CH, Yoon DW, Baik I. Association between snoring and leukocyte telomere length. SLEEP 2016;39(4):767–772. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Zopiclone Increases the Arousal Threshold without Impairing Genioglossus Activity in Obstructive Sleep Apnea
Conclusions:
In a group of patients with predominantly severe OSA, zopiclone increased the arousal threshold without reducing genioglossus muscle activity or its responsiveness to negative pharyngeal pressure. These properties may be beneficial in some patients with OSA with certain pathophysiological characteristics but may worsen hypoxemia in others.
Clinical Trial Registration:
Australian New Zealand Clinical Trials Registry, http://www.anzctr.org.au, trial ID: ACTRN12614000364673.
Citation:
Carter SG, Berger MS, Carberry JC, Bilston LE, Butler JE, Tong BK, Martins RT, Fisher LP, McKenzie DK, Grunstein RR, Eckert DJ...
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype
Conclusions:IL1R2 hypomethylation and AR hypermethylation may constitute an important determinant of disease severity, whereas NPR2 hypomethylation and SP140 hypermethylation may provide a biomarker for vulnerability to EDS in OSA.Commentary:A commentary on this article appears in this issue on page 723.Citation:Chen YC, Chen TW, Su MC, Chen CJ, Chen KD, Liou CW, Tang P, Wang TY, Chang JC, Wang CC, Lin HC, Chin CH, Huang KT, Lin MC, Hsiao CC. Whole genome DNA methylation analysis of obstructive sleep apnea: IL1R2, NPR2, AR, SP140 methylation and clinical phenotype. SLEEP 2016;39(4):743–755. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
Perinatal Risk Factors Associated with the Obstructive Sleep Apnea Syndrome in School-Aged Children Born Preterm
Conclusions:OSAS is very frequent, and is associated with chorioamnionitis and multiple gestation in ex-preterm children. Those born to older white mothers appear to be protected. We speculate that the former may be due to systemic inflammation and the latter to a higher socio-economic status.Commentary:A commentary on this article appears in this issue on page 721.Citation:Tapia IE, Shults J, Doyle LW, Nixon GM, Cielo CM, Traylor J, Marcus CL. Perinatal risk factors associated with the obstructive sleep apnea syndrome in school-aged children born preterm. SLEEP 2016;39(4):737–742. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
